CA2700331A1

CA2700331A1 - Co-administration of pimavanserin with other agents

Co-administration of pimavanserin with other agents Download PDF

Info

Publication number: CA2700331A1
Authority: CA; Canada
Prior art keywords: disorder; composition; agent; disease; pimavanserin
Prior art date: 2007-09-21
Legal status : Abandoned

Application number

CA2700331A

Other languages

English (en)

French (fr)

Inventor

Uli Hacksell

Krista Mcfarland

Current Assignee

Acadia Pharmaceuticals Inc

Original Assignee

Individual

Priority date

2007-09-21

Filing date

2008-09-19

Publication date

2009-03-26

2008-09-19 Application filed by Individual filed Critical Individual

2009-03-26 Publication of CA2700331A1 publication Critical patent/CA2700331A1/en

Status Abandoned legal-status Critical Current

Links

RKEWSXXUOLRFBX-UHFFFAOYSA-N pimavanserin Chemical compound C1=CC(OCC(C)C)=CC=C1CNC(=O)N(C1CCN(C)CC1)CC1=CC=C(F)C=C1 RKEWSXXUOLRFBX-UHFFFAOYSA-N 0.000 title claims abstract description 97
229960003300 pimavanserin Drugs 0.000 title claims abstract description 94
238000011260 co-administration Methods 0.000 title abstract description 11
230000005856 abnormality Effects 0.000 claims abstract description 68
230000001713 cholinergic effect Effects 0.000 claims abstract description 68
239000000203 mixture Substances 0.000 claims abstract description 66
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 52
238000000034 method Methods 0.000 claims abstract description 43
201000010099 disease Diseases 0.000 claims abstract description 33
239000003795 chemical substances by application Substances 0.000 claims description 76
208000028017 Psychotic disease Diseases 0.000 claims description 35
YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims description 33
229960001685 tacrine Drugs 0.000 claims description 32
239000005557 antagonist Substances 0.000 claims description 21
208000024827 Alzheimer disease Diseases 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 20
239000000544 cholinesterase inhibitor Substances 0.000 claims description 19
208000035475 disorder Diseases 0.000 claims description 19
238000011282 treatment Methods 0.000 claims description 18
229940125425 inverse agonist Drugs 0.000 claims description 14
239000000472 muscarinic agonist Substances 0.000 claims description 14
JOLJIIDDOBNFHW-UHFFFAOYSA-N xanomeline Chemical compound CCCCCCOC1=NSN=C1C1=CCCN(C)C1 JOLJIIDDOBNFHW-UHFFFAOYSA-N 0.000 claims description 14
229950006755 xanomeline Drugs 0.000 claims description 14
229940122041 Cholinesterase inhibitor Drugs 0.000 claims description 13
230000000848 glutamatergic effect Effects 0.000 claims description 12
206010012289 Dementia Diseases 0.000 claims description 11
201000000980 schizophrenia Diseases 0.000 claims description 11
239000002207 metabolite Substances 0.000 claims description 10
208000015122 neurodegenerative disease Diseases 0.000 claims description 10
PHOZOHFUXHPOCK-QMMMGPOBSA-N (2s)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one Chemical compound N1C(=O)[C@H](CC)SC11CCN(C)CC1 PHOZOHFUXHPOCK-QMMMGPOBSA-N 0.000 claims description 9
208000018737 Parkinson disease Diseases 0.000 claims description 9
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 8
HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 claims description 8
208000010877 cognitive disease Diseases 0.000 claims description 8
ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 8
229940122312 Choline uptake stimulant Drugs 0.000 claims description 7
208000002193 Pain Diseases 0.000 claims description 7
239000000064 cholinergic agonist Substances 0.000 claims description 7
208000028173 post-traumatic stress disease Diseases 0.000 claims description 7
BKMCUGFGPQNYHG-RSAXXLAASA-N (1r)-1-(1-benzothiophen-5-yl)-2-[2-(diethylamino)ethoxy]ethanol;hydrochloride Chemical compound Cl.CCN(CC)CCOC[C@H](O)C1=CC=C2SC=CC2=C1 BKMCUGFGPQNYHG-RSAXXLAASA-N 0.000 claims description 6
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 6
108010066477 Carnitine O-acetyltransferase Proteins 0.000 claims description 6
102100036357 Carnitine O-acetyltransferase Human genes 0.000 claims description 6
229940121743 Muscarinic receptor agonist Drugs 0.000 claims description 6
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims description 6
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims description 6
208000028810 Shared psychotic disease Diseases 0.000 claims description 6
208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 6
PSPGQHXMUKWNDI-UHFFFAOYSA-N coluracetam Chemical group C=12C(C)=C(C)OC2=NC=2CCCCC=2C=1NC(=O)CN1CCCC1=O PSPGQHXMUKWNDI-UHFFFAOYSA-N 0.000 claims description 6
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 6
208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims description 6
RJSVKPQKXSMZMT-UHFFFAOYSA-N 4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol;hydrochloride Chemical group Cl.CN1CCCC1CCSC1=CC=C(O)C=C1 RJSVKPQKXSMZMT-UHFFFAOYSA-N 0.000 claims description 5
229940121975 Acetylcholine release stimulant Drugs 0.000 claims description 5
229940122309 Acetyltransferase stimulant Drugs 0.000 claims description 5
208000019901 Anxiety disease Diseases 0.000 claims description 5
206010003591 Ataxia Diseases 0.000 claims description 5
208000028698 Cognitive impairment Diseases 0.000 claims description 5
201000010374 Down Syndrome Diseases 0.000 claims description 5
201000011240 Frontotemporal dementia Diseases 0.000 claims description 5
208000023105 Huntington disease Diseases 0.000 claims description 5
RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 5
208000000323 Tourette Syndrome Diseases 0.000 claims description 5
230000003542 behavioural effect Effects 0.000 claims description 5
BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 5
229960004640 memantine Drugs 0.000 claims description 5
229940122578 Acetylcholine receptor agonist Drugs 0.000 claims description 4
206010001488 Aggression Diseases 0.000 claims description 4
208000020925 Bipolar disease Diseases 0.000 claims description 4
208000010412 Glaucoma Diseases 0.000 claims description 4
208000004547 Hallucinations Diseases 0.000 claims description 4
230000036506 anxiety Effects 0.000 claims description 4
229960003530 donepezil Drugs 0.000 claims description 4
206010027175 memory impairment Diseases 0.000 claims description 4
208000019116 sleep disease Diseases 0.000 claims description 4
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims description 3
UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 claims description 3
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 3
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims description 3
VOCIDCRQVWWXDF-UHFFFAOYSA-N 2,3,3a,4-tetrahydrofuro[2,3-e][1]benzofuran Chemical compound C1C=C2OC=CC2=C2OCCC21 VOCIDCRQVWWXDF-UHFFFAOYSA-N 0.000 claims description 3
VGGGBQVTSUMURJ-UHFFFAOYSA-N 2,8-dimethyl-1-thia-3,8-diazaspiro[4.5]dec-2-ene Chemical compound C1CN(C)CCC11SC(C)=NC1 VGGGBQVTSUMURJ-UHFFFAOYSA-N 0.000 claims description 3
KZAJTVRKNKAXAG-UHFFFAOYSA-N 2-[4-[3-(3-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OCCN2CCN(CCCN3C4=CC=C(Cl)C=C4SC4=CC=CC=C43)CC2)=C1 KZAJTVRKNKAXAG-UHFFFAOYSA-N 0.000 claims description 3
VPJXQGSRWJZDOB-UHFFFAOYSA-O 2-carbamoyloxyethyl(trimethyl)azanium Chemical compound C[N+](C)(C)CCOC(N)=O VPJXQGSRWJZDOB-UHFFFAOYSA-O 0.000 claims description 3
CWEHWZPCDBRUNO-WLHGVMLRSA-N 3-(1-benzylpiperidin-4-yl)-1-(2,3,4,5-tetrahydro-1h-1-benzazepin-8-yl)propan-1-one;(e)-but-2-enedioic acid Chemical compound OC(=O)\C=C\C(O)=O.C=1C=C2CCCCNC2=CC=1C(=O)CCC(CC1)CCN1CC1=CC=CC=C1 CWEHWZPCDBRUNO-WLHGVMLRSA-N 0.000 claims description 3
229940124801 5-HT6 antagonist Drugs 0.000 claims description 3
USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 3
229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims description 3
208000000044 Amnesia Diseases 0.000 claims description 3
206010003805 Autism Diseases 0.000 claims description 3
208000020706 Autistic disease Diseases 0.000 claims description 3
MYTVVMGUDBRCDJ-UHFFFAOYSA-N Bufencarb Chemical compound CCCC(C)C1=CC=CC(OC(=O)NC)=C1.CCC(CC)C1=CC=CC(OC(=O)NC)=C1 MYTVVMGUDBRCDJ-UHFFFAOYSA-N 0.000 claims description 3
TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 claims description 3
239000005490 Carbetamide Substances 0.000 claims description 3
ULBXWWGWDPVHAO-UHFFFAOYSA-N Chlorbufam Chemical compound C#CC(C)OC(=O)NC1=CC=CC(Cl)=C1 ULBXWWGWDPVHAO-UHFFFAOYSA-N 0.000 claims description 3
239000012848 Dextrorphan Substances 0.000 claims description 3
IOIMDJXKIMCMIG-UHFFFAOYSA-N Diphosphoramide, N,N',N'',N'''-tetrakis(1-methylethyl)- Chemical compound CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C IOIMDJXKIMCMIG-UHFFFAOYSA-N 0.000 claims description 3
208000012661 Dyskinesia Diseases 0.000 claims description 3
VWLHWLSRQJQWRG-UHFFFAOYSA-O Edrophonum Chemical compound CC[N+](C)(C)C1=CC=CC(O)=C1 VWLHWLSRQJQWRG-UHFFFAOYSA-O 0.000 claims description 3
239000005976 Ethephon Substances 0.000 claims description 3
239000005948 Formetanate Substances 0.000 claims description 3
ZRJBHWIHUMBLCN-SEQYCRGISA-N Huperzine A Natural products N1C(=O)C=CC2=C1C[C@H]1/C(=C/C)[C@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-SEQYCRGISA-N 0.000 claims description 3
YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims description 3
MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 claims description 3
201000002832 Lewy body dementia Diseases 0.000 claims description 3
206010026749 Mania Diseases 0.000 claims description 3
208000026139 Memory disease Diseases 0.000 claims description 3
239000005951 Methiocarb Substances 0.000 claims description 3
239000005916 Methomyl Substances 0.000 claims description 3
239000005950 Oxamyl Substances 0.000 claims description 3
RSDOPYMFZBJHRL-UHFFFAOYSA-N Oxotremorine Chemical compound O=C1CCCN1CC#CCN1CCCC1 RSDOPYMFZBJHRL-UHFFFAOYSA-N 0.000 claims description 3
239000005594 Phenmedipham Substances 0.000 claims description 3
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 claims description 3
208000000609 Pick Disease of the Brain Diseases 0.000 claims description 3
208000024571 Pick disease Diseases 0.000 claims description 3
GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 claims description 3
239000005923 Pirimicarb Substances 0.000 claims description 3
239000005821 Propamocarb Substances 0.000 claims description 3
RVOLLAQWKVFTGE-UHFFFAOYSA-N Pyridostigmine Chemical compound CN(C)C(=O)OC1=CC=C[N+](C)=C1 RVOLLAQWKVFTGE-UHFFFAOYSA-N 0.000 claims description 3
ISRUGXGCCGIOQO-UHFFFAOYSA-N Rhoden Chemical compound CNC(=O)OC1=CC=CC=C1OC(C)C ISRUGXGCCGIOQO-UHFFFAOYSA-N 0.000 claims description 3
XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 3
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims description 3
ZRJBHWIHUMBLCN-UHFFFAOYSA-N Shuangyiping Natural products N1C(=O)C=CC2=C1CC1C(=CC)C2(N)CC(C)=C1 ZRJBHWIHUMBLCN-UHFFFAOYSA-N 0.000 claims description 3
208000034972 Sudden Infant Death Diseases 0.000 claims description 3
206010042440 Sudden infant death syndrome Diseases 0.000 claims description 3
VOXIUXZAOFEFBL-UHFFFAOYSA-N Voacangin Natural products CCC1CC2CN3CC1C(C2)(OC(=O)C)c4[nH]c5ccc(OC)cc5c4C3 VOXIUXZAOFEFBL-UHFFFAOYSA-N 0.000 claims description 3
AMRQXHFXNZFDCH-SECBINFHSA-N [(2r)-1-(ethylamino)-1-oxopropan-2-yl] n-phenylcarbamate Chemical compound CCNC(=O)[C@@H](C)OC(=O)NC1=CC=CC=C1 AMRQXHFXNZFDCH-SECBINFHSA-N 0.000 claims description 3
PBHFNBQPZCRWQP-QUCCMNQESA-N [(3ar,8bs)-3,4,8b-trimethyl-2,3a-dihydro-1h-pyrrolo[2,3-b]indol-7-yl] n-phenylcarbamate Chemical compound CN([C@@H]1[C@@](C2=C3)(C)CCN1C)C2=CC=C3OC(=O)NC1=CC=CC=C1 PBHFNBQPZCRWQP-QUCCMNQESA-N 0.000 claims description 3
ZOBDWFRKFSPCRB-UNMCSNQZSA-N [(4as,9as)-2,4a,9-trimethyl-4,9a-dihydro-3h-oxazino[6,5-b]indol-6-yl] n-(2-ethylphenyl)carbamate Chemical compound CCC1=CC=CC=C1NC(=O)OC1=CC=C(N(C)[C@@H]2[C@@]3(C)CCN(C)O2)C3=C1 ZOBDWFRKFSPCRB-UNMCSNQZSA-N 0.000 claims description 3
229960003216 aceclidine Drugs 0.000 claims description 3
WRJPSSPFHGNBMG-UHFFFAOYSA-N acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester Chemical compound C1CC2C(OC(=O)C)CN1CC2 WRJPSSPFHGNBMG-UHFFFAOYSA-N 0.000 claims description 3
230000007000 age related cognitive decline Effects 0.000 claims description 3
QGLZXHRNAYXIBU-WEVVVXLNSA-N aldicarb Chemical compound CNC(=O)O\N=C\C(C)(C)SC QGLZXHRNAYXIBU-WEVVVXLNSA-N 0.000 claims description 3
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims description 3
229960003805 amantadine Drugs 0.000 claims description 3
OMHBPUNFVFNHJK-UHFFFAOYSA-P ambenonium Chemical compound C=1C=CC=C(Cl)C=1C[N+](CC)(CC)CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl OMHBPUNFVFNHJK-UHFFFAOYSA-P 0.000 claims description 3
229960000451 ambenonium Drugs 0.000 claims description 3
XEGGRYVFLWGFHI-UHFFFAOYSA-N bendiocarb Chemical compound CNC(=O)OC1=CC=CC2=C1OC(C)(C)O2 XEGGRYVFLWGFHI-UHFFFAOYSA-N 0.000 claims description 3
OTPPJICEBWOCKD-UHFFFAOYSA-N besipirdine Chemical compound C1=CC2=CC=CC=C2N1N(CCC)C1=CC=NC=C1 OTPPJICEBWOCKD-UHFFFAOYSA-N 0.000 claims description 3
229950005017 besipirdine Drugs 0.000 claims description 3
NZUPCNDJBJXXRF-UHFFFAOYSA-O bethanechol Chemical compound C[N+](C)(C)CC(C)OC(N)=O NZUPCNDJBJXXRF-UHFFFAOYSA-O 0.000 claims description 3
229960000910 bethanechol Drugs 0.000 claims description 3
FFSAXUULYPJSKH-UHFFFAOYSA-N butyrophenone Chemical class CCCC(=O)C1=CC=CC=C1 FFSAXUULYPJSKH-UHFFFAOYSA-N 0.000 claims description 3
CVXBEEMKQHEXEN-UHFFFAOYSA-N carbaryl Chemical compound C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 CVXBEEMKQHEXEN-UHFFFAOYSA-N 0.000 claims description 3
229960005286 carbaryl Drugs 0.000 claims description 3
239000006013 carbendazim Substances 0.000 claims description 3
JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 claims description 3
DUEPRVBVGDRKAG-UHFFFAOYSA-N carbofuran Chemical compound CNC(=O)OC1=CC=CC2=C1OC(C)(C)C2 DUEPRVBVGDRKAG-UHFFFAOYSA-N 0.000 claims description 3
WUTYZMFRCNBCHQ-PSASIEDQSA-N cevimeline Chemical compound C1S[C@H](C)O[C@]21C(CC1)CCN1C2 WUTYZMFRCNBCHQ-PSASIEDQSA-N 0.000 claims description 3
229960001314 cevimeline Drugs 0.000 claims description 3
CWJSHJJYOPWUGX-UHFFFAOYSA-N chlorpropham Chemical compound CC(C)OC(=O)NC1=CC=CC(Cl)=C1 CWJSHJJYOPWUGX-UHFFFAOYSA-N 0.000 claims description 3
NKJRRVBTMYRXRB-GGAORHGYSA-N cymserine Chemical compound C1=CC(C(C)C)=CC=C1NC(=O)OC1=CC=C(N(C)[C@@H]2[C@@]3(C)CCN2C)C3=C1 NKJRRVBTMYRXRB-GGAORHGYSA-N 0.000 claims description 3
RWZVPVOZTJJMNU-UHFFFAOYSA-N demarcarium Chemical compound C=1C=CC([N+](C)(C)C)=CC=1OC(=O)N(C)CCCCCCCCCCN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 RWZVPVOZTJJMNU-UHFFFAOYSA-N 0.000 claims description 3
229960001985 dextromethorphan Drugs 0.000 claims description 3
JAQUASYNZVUNQP-PVAVHDDUSA-N dextrorphan Chemical compound C1C2=CC=C(O)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 JAQUASYNZVUNQP-PVAVHDDUSA-N 0.000 claims description 3
229950006878 dextrorphan Drugs 0.000 claims description 3
MUCZHBLJLSDCSD-UHFFFAOYSA-N diisopropyl fluorophosphate Chemical compound CC(C)OP(F)(=O)OC(C)C MUCZHBLJLSDCSD-UHFFFAOYSA-N 0.000 claims description 3
229960002017 echothiophate Drugs 0.000 claims description 3
BJOLKYGKSZKIGU-UHFFFAOYSA-N ecothiopate Chemical compound CCOP(=O)(OCC)SCC[N+](C)(C)C BJOLKYGKSZKIGU-UHFFFAOYSA-N 0.000 claims description 3
229960003748 edrophonium Drugs 0.000 claims description 3
HEZNVIYQEUHLNI-UHFFFAOYSA-N ethiofencarb Chemical compound CCSCC1=CC=CC=C1OC(=O)NC HEZNVIYQEUHLNI-UHFFFAOYSA-N 0.000 claims description 3
229960005051 fluostigmine Drugs 0.000 claims description 3
RMFNNCGOSPBBAD-MDWZMJQESA-N formetanate Chemical compound CNC(=O)OC1=CC=CC(\N=C\N(C)C)=C1 RMFNNCGOSPBBAD-MDWZMJQESA-N 0.000 claims description 3
229960003980 galantamine Drugs 0.000 claims description 3
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 3
229950000264 ganstigmine Drugs 0.000 claims description 3
ZRJBHWIHUMBLCN-YQEJDHNASA-N huperzine A Chemical compound N1C(=O)C=CC2=C1C[C@H]1\C(=C/C)[C@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-YQEJDHNASA-N 0.000 claims description 3
HSIBGVUMFOSJPD-CFDPKNGZSA-N ibogaine Chemical compound N1([C@@H]2[C@H]3C[C@H](C1)C[C@@H]2CC)CCC1=C3NC2=CC=C(OC)C=C12 HSIBGVUMFOSJPD-CFDPKNGZSA-N 0.000 claims description 3
OLOCMRXSJQJJPL-UHFFFAOYSA-N ibogaine Natural products CCC1CC2CC3C1N(C2)C=Cc4c3[nH]c5ccc(OC)cc45 OLOCMRXSJQJJPL-UHFFFAOYSA-N 0.000 claims description 3
AREITJMUSRHSBK-UHFFFAOYSA-N ibogamine Natural products CCC1CC2C3CC1CN2CCc4c3[nH]c5ccccc45 AREITJMUSRHSBK-UHFFFAOYSA-N 0.000 claims description 3
229960003299 ketamine Drugs 0.000 claims description 3
JNODQFNWMXFMEV-UHFFFAOYSA-N latrepirdine Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2CCC1=CC=C(C)N=C1 JNODQFNWMXFMEV-UHFFFAOYSA-N 0.000 claims description 3
229960001518 levocarnitine Drugs 0.000 claims description 3
230000006984 memory degeneration Effects 0.000 claims description 3
208000023060 memory loss Diseases 0.000 claims description 3
NZWOPGCLSHLLPA-UHFFFAOYSA-N methacholine Chemical compound C[N+](C)(C)CC(C)OC(C)=O NZWOPGCLSHLLPA-UHFFFAOYSA-N 0.000 claims description 3
229960002329 methacholine Drugs 0.000 claims description 3
229960001797 methadone Drugs 0.000 claims description 3
YFBPRJGDJKVWAH-UHFFFAOYSA-N methiocarb Chemical compound CNC(=O)OC1=CC(C)=C(SC)C(C)=C1 YFBPRJGDJKVWAH-UHFFFAOYSA-N 0.000 claims description 3
UHXUZOCRWCRNSJ-QPJJXVBHSA-N methomyl Chemical compound CNC(=O)O\N=C(/C)SC UHXUZOCRWCRNSJ-QPJJXVBHSA-N 0.000 claims description 3
229960001952 metrifonate Drugs 0.000 claims description 3
YMMXHEYLRHNXAB-RMKNXTFCSA-N milameline Chemical compound CO\N=C\C1=CCCN(C)C1 YMMXHEYLRHNXAB-RMKNXTFCSA-N 0.000 claims description 3
229950004373 milameline Drugs 0.000 claims description 3
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