CA2697057A1 - Therapy for complications of diabetes - Google Patents
Therapy for complications of diabetes Download PDFInfo
- Publication number
- CA2697057A1 CA2697057A1 CA2697057A CA2697057A CA2697057A1 CA 2697057 A1 CA2697057 A1 CA 2697057A1 CA 2697057 A CA2697057 A CA 2697057A CA 2697057 A CA2697057 A CA 2697057A CA 2697057 A1 CA2697057 A1 CA 2697057A1
- Authority
- CA
- Canada
- Prior art keywords
- selective
- receptor antagonist
- group
- darusentan
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2904447A CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95730007P | 2007-08-22 | 2007-08-22 | |
US60/957,300 | 2007-08-22 | ||
PCT/US2008/074013 WO2009026517A2 (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2904447A Division CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2697057A1 true CA2697057A1 (en) | 2009-02-26 |
Family
ID=40220116
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2697057A Abandoned CA2697057A1 (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
CA2904447A Expired - Fee Related CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2904447A Expired - Fee Related CA2904447C (en) | 2007-08-22 | 2008-08-22 | Therapy for complications of diabetes |
Country Status (5)
Country | Link |
---|---|
US (5) | US20090054473A1 (ja) |
EP (2) | EP2190433A2 (ja) |
JP (5) | JP2010536880A (ja) |
CA (2) | CA2697057A1 (ja) |
WO (1) | WO2009026517A2 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070196510A1 (en) * | 2006-02-17 | 2007-08-23 | Gerber Michael J | Method for treating resistant hypertension |
CA2695259C (en) * | 2007-07-31 | 2016-05-24 | Gilead Colorado, Inc. | Metabolites and derivatives of ambrisentan |
EP2190433A2 (en) * | 2007-08-22 | 2010-06-02 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
CN101632672B (zh) * | 2008-07-24 | 2011-01-12 | 鲁南制药集团股份有限公司 | 一种用于治疗高血压的复方药物组合物 |
BRPI1013904A2 (pt) * | 2009-04-30 | 2016-07-19 | Univ Midwestern | método e composição para tratar cetoacidose diabética |
US9255931B2 (en) * | 2010-06-24 | 2016-02-09 | Morehouse School Of Medicine | Method and compositions for the treatment and detection of endothelin-1 related kidney diseases |
EP2727587A1 (en) * | 2012-10-30 | 2014-05-07 | Pharnext | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level |
KR20160003128A (ko) | 2013-04-30 | 2016-01-08 | 애브비 인코포레이티드 | 아트라센탄을 사용하는 지질 프로파일을 개선시키기 위한 방법 |
TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
JP2017534634A (ja) * | 2014-11-07 | 2017-11-24 | アッヴィ・インコーポレイテッド | 体液貯留の予測因子を使用してckdを処置する方法 |
JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
US10369156B2 (en) * | 2016-11-15 | 2019-08-06 | The George Institute for Global Health | Compositions for the treatment of hypertension |
KR20240096848A (ko) | 2017-01-25 | 2024-06-26 | 더 조지 인스티튜트 포 글로벌 헬스 | 고혈압의 치료를 위한 조성물 |
WO2018153513A1 (en) | 2017-02-27 | 2018-08-30 | Idorsia Pharmaceuticals Ltd | Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases |
US20190260657A1 (en) * | 2018-02-21 | 2019-08-22 | Cisco Technology, Inc. | In-band performance loss measurement in ipv6/srv6 software defined networks |
EP4364811A3 (en) * | 2018-05-03 | 2024-07-10 | Midwestern University | Alterations in endothelin receptors following hemorrhage and resuscitation by centhaquin |
US20210186930A1 (en) * | 2018-05-23 | 2021-06-24 | University Of Miami | Methods of Treating Renal Disease Associated With Chronic Kidney Disease Such as Alport Syndrome |
MX2021001043A (es) * | 2018-07-26 | 2021-04-12 | The George Inst For Global Health | Composiciones para el tratamiento de hipertension. |
MX2022005063A (es) * | 2019-10-30 | 2022-08-04 | Perfuse Therapeutics Inc | Tratamiento de enfermedades oculares con antagonistas de receptor de endotelina. |
KR20230015874A (ko) | 2019-12-17 | 2023-01-31 | 치누크 세라퓨틱스, 인크. | 아트라센탄에 의해 iga 신장병증을 치료하는 방법 |
KR20230038234A (ko) | 2020-07-10 | 2023-03-17 | 아스트라제네카 아베 | 만성 신장 질환 치료를 위한 지보텐탄 및 다파글리플로진의 조합 |
KR20240004643A (ko) | 2021-04-30 | 2024-01-11 | 퍼퓨즈 세라퓨틱스, 인크. | 안구 질환의 치료를 위한 제약 조성물 및 유리체내 약물 전달 시스템 |
CN116804048A (zh) * | 2023-02-24 | 2023-09-26 | 中国农业大学 | 豌豆白蛋白分离肽、组合物及其用途 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0647449A1 (en) * | 1993-06-24 | 1995-04-12 | Takeda Chemical Industries, Ltd. | Sustained-release preparation of anti-endothelin substance |
CZ285522B6 (cs) * | 1993-06-24 | 1999-08-11 | Eli Lilly And Company | Farmaceutický prostředek pro snížení koncentrace glukosy v krvi |
US7208517B1 (en) * | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
ATE219077T1 (de) | 1994-08-19 | 2002-06-15 | Abbott Lab | Endothelin antagoniste |
US6162927A (en) * | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
US7365093B2 (en) * | 1994-08-19 | 2008-04-29 | Abbott Laboratories | Endothelin antagonists |
US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
US6946481B1 (en) * | 1994-08-19 | 2005-09-20 | Abbott Laboratories | Endothelin antagonists |
EP1609790A3 (en) | 1996-02-13 | 2006-01-04 | Abbott Laboratories | Benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists |
US6420412B2 (en) * | 1996-03-29 | 2002-07-16 | Smithkline Beecham Corporation | Eprosartan dihydate and a process for its production and formulation |
US6121416A (en) * | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
NZ502395A (en) | 1997-08-04 | 2002-08-28 | Abbott Lab | 4-Benzodioxolyl substituted pyrrolidine-3-carboxylic acid derivatives useful as endothelin antagonists |
US7445792B2 (en) * | 2003-03-10 | 2008-11-04 | Abbott Laboratories | Medical device having a hydration inhibitor |
CA2304712C (en) | 1997-09-26 | 2008-04-29 | Knoll Aktiengesellschaft | Endothelin antagonist and a renin-angiotensin system inhibitor as a combined preparation |
US8257725B2 (en) * | 1997-09-26 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
DE19743140A1 (de) | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
DE19743143A1 (de) | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
DE19743142A1 (de) | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
DE19744799A1 (de) | 1997-10-10 | 1999-04-15 | Knoll Ag | Pharmazeutische Kombinationspräparate |
DE19754082A1 (de) | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
CA2342217C (en) | 1998-09-14 | 2009-12-15 | Abbott Laboratories | Process for producing stereoselective nitro compounds |
US8257724B2 (en) * | 1998-09-24 | 2012-09-04 | Abbott Laboratories | Delivery of highly lipophilic agents via medical devices |
US6238708B1 (en) * | 1999-02-23 | 2001-05-29 | The Iams Company | Composition and process for controlling glucose metabolism in companion animals by dietary starch |
US6559188B1 (en) * | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
US20020055457A1 (en) * | 2000-08-07 | 2002-05-09 | Janus Todd J. | Methods of treating cancer and the pain associated therewith using endothelin antagonists |
TWI306760B (en) | 2000-08-07 | 2009-03-01 | Abbott Lab | Use of an endothelin et-a receptor antagonist and orally delivered pharmaceutical composition comprising the same |
WO2002017912A1 (en) | 2000-08-31 | 2002-03-07 | Abbott Laboratories | Endothelin antagonists |
US20030092757A1 (en) * | 2001-04-11 | 2003-05-15 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
MXPA03009277A (es) | 2001-04-11 | 2004-03-10 | Abbott Lab | Modulacion favorable de calidad de vida relacionada con la salud y progreso de la enfermedad con el paso del tiempo ajustado a la calidad relacionada con la salud en pacientes con cancer de prostata. |
US20030022811A1 (en) * | 2001-04-11 | 2003-01-30 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
WO2003027091A1 (en) * | 2001-09-21 | 2003-04-03 | Novartis Ag | Pyrane derivatives as both ace- and nep- inhibitors |
WO2003080038A1 (fr) * | 2002-03-22 | 2003-10-02 | Kissei Pharmaceutical Co., Ltd. | Agent prophylactique ou therapeutique contre des maladies renales |
GB0212412D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Combination of organic compounds |
CL2004000545A1 (es) | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
CN101884789A (zh) * | 2004-02-11 | 2010-11-17 | 法布罗根股份有限公司 | Ctgf作为糖尿病肾病的治疗靶点 |
BRPI0508880A (pt) * | 2004-03-17 | 2007-09-04 | Novartis Ag | uso de compostos orgánicos |
ATE534424T1 (de) * | 2004-03-19 | 2011-12-15 | Abbott Lab | Mehrfache arzneiabgabe aus einem ballon und eine prothese |
US9051301B2 (en) * | 2004-09-17 | 2015-06-09 | Abbvie Inc. | Crystalline form of a drug |
WO2006034085A1 (en) | 2004-09-17 | 2006-03-30 | Abbott Laboratories | Crystalline form of atrasentan hydrochloride |
US20060189675A1 (en) * | 2004-09-17 | 2006-08-24 | Steve King | Crystalline form of a drug |
WO2006034084A1 (en) | 2004-09-17 | 2006-03-30 | Abbott Laboratories | Crystalline form 2 of atrasentan hydrochloride |
AU2006250354A1 (en) * | 2005-05-23 | 2006-11-30 | Japan Tobacco Inc. | Pyrazole compound and therapeutic agent for diabetes comprising the same |
US20080132710A1 (en) * | 2006-12-04 | 2008-06-05 | Abbott Laboratories | Atrasentan hydrochloride crystalline form 2 |
EP2190433A2 (en) * | 2007-08-22 | 2010-06-02 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
US20100184026A1 (en) * | 2009-01-22 | 2010-07-22 | Abbott Laboratories | Companion Diagnostic Assays For Endothelin Receptor Antagonists |
-
2008
- 2008-08-22 EP EP08798489A patent/EP2190433A2/en not_active Withdrawn
- 2008-08-22 US US12/196,635 patent/US20090054473A1/en not_active Abandoned
- 2008-08-22 WO PCT/US2008/074013 patent/WO2009026517A2/en active Application Filing
- 2008-08-22 JP JP2010522066A patent/JP2010536880A/ja active Pending
- 2008-08-22 CA CA2697057A patent/CA2697057A1/en not_active Abandoned
- 2008-08-22 EP EP12182366A patent/EP2545920A1/en not_active Withdrawn
- 2008-08-22 CA CA2904447A patent/CA2904447C/en not_active Expired - Fee Related
-
2013
- 2013-02-13 US US13/766,266 patent/US8623819B2/en active Active
- 2013-09-05 JP JP2013183975A patent/JP2014001234A/ja active Pending
- 2013-11-13 US US14/079,464 patent/US8865650B2/en active Active
-
2014
- 2014-09-19 US US14/491,479 patent/US9592231B2/en not_active Expired - Fee Related
- 2014-09-29 JP JP2014198604A patent/JP2015028062A/ja active Pending
-
2015
- 2015-10-30 JP JP2015214045A patent/JP2016053057A/ja active Pending
-
2016
- 2016-12-02 US US15/368,016 patent/US20170079978A1/en not_active Abandoned
-
2017
- 2017-02-28 JP JP2017035751A patent/JP2017145251A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2017145251A (ja) | 2017-08-24 |
EP2190433A2 (en) | 2010-06-02 |
US20090054473A1 (en) | 2009-02-26 |
JP2016053057A (ja) | 2016-04-14 |
JP2015028062A (ja) | 2015-02-12 |
US20170079978A1 (en) | 2017-03-23 |
WO2009026517A3 (en) | 2009-05-28 |
US8865650B2 (en) | 2014-10-21 |
US9592231B2 (en) | 2017-03-14 |
US20150051234A1 (en) | 2015-02-19 |
US20140073574A1 (en) | 2014-03-13 |
US20130178424A1 (en) | 2013-07-11 |
CA2904447A1 (en) | 2009-02-26 |
WO2009026517A2 (en) | 2009-02-26 |
JP2010536880A (ja) | 2010-12-02 |
JP2014001234A (ja) | 2014-01-09 |
CA2904447C (en) | 2017-01-03 |
EP2545920A1 (en) | 2013-01-16 |
US8623819B2 (en) | 2014-01-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9592231B2 (en) | Therapy for complications of diabetes | |
US20070196510A1 (en) | Method for treating resistant hypertension | |
RU2310443C2 (ru) | Синергетические композиции, которые содержат ингибитор ренина, предназначенные для лечения сердечно-сосудистых заболеваний | |
JP6337170B2 (ja) | ネコの全身性疾患の予防又は治療の為のアンジオテンシンii受容体アンタゴニスト | |
US20070293552A1 (en) | Antihypertensive therapy method | |
JP2005533023A5 (ja) | ||
TW201924685A (zh) | 用於治療內皮素相關疾病之4-嘧啶磺醯胺衍生物與sglt-2抑制劑之組合 | |
US20090221549A1 (en) | Antihypertensive therapy | |
WO2006130901A1 (en) | Control of metabolic abnormalities | |
CN101822837A (zh) | 包含艾力沙坦酯盐的药物组合物 | |
JP2018521077A (ja) | 糖尿病性腎症を治療するためのpde4阻害剤 | |
Liu | Identification and Characterization of Antidiabetic and Antihypertensive Agents from Three Traditional Herbal Medicines | |
CN102166357A (zh) | 包含双环氮杂烷类衍生物的药物组合物 | |
CN101810859A (zh) | 包含苯胺衍生物的药物组合物 | |
WO2008100803A1 (en) | Antihypertensive drug combination |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20130821 |
|
FZDE | Dead |
Effective date: 20171121 |