CA2693378C - Myostatin antagonists - Google Patents
Myostatin antagonists Download PDFInfo
- Publication number
- CA2693378C CA2693378C CA2693378A CA2693378A CA2693378C CA 2693378 C CA2693378 C CA 2693378C CA 2693378 A CA2693378 A CA 2693378A CA 2693378 A CA2693378 A CA 2693378A CA 2693378 C CA2693378 C CA 2693378C
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- Prior art keywords
- myostatin
- muscle
- polypeptide
- fusion protein
- sequence
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Classifications
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Landscapes
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- Endocrinology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83552506P | 2006-08-03 | 2006-08-03 | |
| US60/835,525 | 2006-08-03 | ||
| PCT/NZ2007/000203 WO2008016314A1 (en) | 2006-08-03 | 2007-08-02 | Myostatin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
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| CA2693378C true CA2693378C (en) | 2020-04-14 |
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Families Citing this family (21)
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| ATE552272T1 (de) * | 2004-09-30 | 2012-04-15 | Orico Ltd | Myostatin-isoform |
| HUE035240T2 (hu) * | 2009-04-27 | 2018-05-02 | Novartis Ag | Készítmények és eljárások az izomerõ növelésére |
| CN101659700B (zh) * | 2009-07-27 | 2011-11-16 | 广州罗森生物科技有限公司 | 一种短肽 |
| AU2010301196A1 (en) * | 2009-10-01 | 2012-05-17 | Myostin Therapeutics Pty Ltd | Synthetic myostatin peptide antagonists |
| JO3340B1 (ar) * | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| CN103221426B (zh) * | 2010-08-16 | 2016-01-13 | 安姆根公司 | 结合肌肉生长抑制素的抗体、组合物和方法 |
| US8871209B2 (en) | 2011-11-14 | 2014-10-28 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and or Activin A |
| HK1243940A1 (zh) * | 2014-11-06 | 2018-07-27 | Scholar Rock, Inc. | 抗原肌肉生长抑制素/潜在肌肉生长抑制素的抗体及其用途 |
| CA2982810A1 (en) | 2015-04-15 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| CN109071645A (zh) | 2016-01-08 | 2018-12-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| JP7032808B2 (ja) | 2016-08-10 | 2022-03-09 | 学校法人東京薬科大学 | ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ |
| HRP20230308T1 (hr) * | 2017-01-06 | 2023-05-12 | Scholar Rock, Inc. | Liječenje metaboličkih bolesti putem inhibiranja aktivacije miostatina |
| KR20200128125A (ko) | 2018-03-01 | 2020-11-11 | 리제너론 파아마슈티컬스, 인크. | 신체 조성을 변경하기 위한 방법 |
| WO2019178759A1 (zh) * | 2018-03-21 | 2019-09-26 | 维多利亚生物医学控股股份有限公司 | 促进局部肌肉增长、减缓或防止局部肌肉萎缩的组合物及其用途 |
| TWI649332B (zh) | 2018-03-21 | 2019-02-01 | 英屬安圭拉商維多利亞生物醫學控股股份有限公司 | Composition for promoting local muscle growth, slowing or preventing local muscle atrophy and use thereof |
| CN112384247B (zh) * | 2018-07-02 | 2024-09-27 | 库拉米斯公司 | 利用细胞融合技术的基因及细胞治疗剂以及其的用途 |
| US20220119489A1 (en) * | 2019-01-25 | 2022-04-21 | Children's Medical Center Corporation | Compositions and methods for treating muscular dystrophy and related disorders |
| US20220331290A1 (en) * | 2019-09-24 | 2022-10-20 | Myo-Tec-Sci | Pharmaceutical composition for preventing or treating sarcopenia, containing unnatural amino acid |
| AU2021390998A1 (en) * | 2020-12-03 | 2023-06-29 | Kyungsangbukdo (Kyungsangbukdo Livestock Research Institute) | Transgenic animal having modified myostatin gene |
| AU2023413166A1 (en) | 2022-12-22 | 2025-07-03 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
| CN120192396A (zh) * | 2023-12-21 | 2025-06-24 | 江苏省农业科学院 | 一种肌肉生长抑制素mstn蛋白突变体及其制备方法和应用 |
Family Cites Families (16)
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|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| AU6274298A (en) * | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6369201B1 (en) * | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| KR100750695B1 (ko) | 1999-07-20 | 2007-08-22 | 파멕사 에이/에스 | Ｇｄｆ-8 활성을 하향-조절하는 방법 |
| WO2001053350A1 (en) | 2000-01-18 | 2001-07-26 | Agresearch Limited | Myostatin and mimetics thereof |
| EP1523557A2 (en) | 2002-07-24 | 2005-04-20 | Intercell AG | Antigens encoded by alternative reading frame from pathogenic viruses |
| DE60331778D1 (de) | 2002-09-16 | 2010-04-29 | Univ Johns Hopkins | Metalloproteaseaktivierung von myostatin und verfahren zur modulation der myostatinaktivität |
| NZ529860A (en) | 2003-11-28 | 2006-10-27 | Ovita Ltd | Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases |
| SG153874A1 (en) * | 2003-12-31 | 2009-07-29 | Schering Plough Ltd | Neutralizing epitope-based growth enhancing vaccine |
| EP1778275A2 (en) * | 2004-08-12 | 2007-05-02 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors |
| NZ538097A (en) * | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| US20070190056A1 (en) * | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
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- 2007-08-02 EP EP07834817.4A patent/EP2054434B1/en not_active Not-in-force
- 2007-08-02 AU AU2007279456A patent/AU2007279456A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
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| CA2693378A1 (en) | 2008-02-07 |
| JP2014057584A (ja) | 2014-04-03 |
| DK2054434T3 (en) | 2017-07-03 |
| EP2054434A1 (en) | 2009-05-06 |
| US8309068B2 (en) | 2012-11-13 |
| US20090324590A1 (en) | 2009-12-31 |
| EP2054434A4 (en) | 2011-07-13 |
| EP2054434B1 (en) | 2017-03-15 |
| AU2007279456A1 (en) | 2008-02-07 |
| CN101522707A (zh) | 2009-09-02 |
| JP2009545313A (ja) | 2009-12-24 |
| JP2016130251A (ja) | 2016-07-21 |
| WO2008016314A1 (en) | 2008-02-07 |
| BRPI0715072A2 (pt) | 2013-06-25 |
| CN101522707B (zh) | 2013-08-28 |
| JP5993827B2 (ja) | 2016-09-14 |
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