CA2692748A1 - Micelles mixtes renfermant des conjugues amphiphatiques d'agents arn et leurs utilisations - Google Patents
Micelles mixtes renfermant des conjugues amphiphatiques d'agents arn et leurs utilisations Download PDFInfo
- Publication number
- CA2692748A1 CA2692748A1 CA 2692748 CA2692748A CA2692748A1 CA 2692748 A1 CA2692748 A1 CA 2692748A1 CA 2692748 CA2692748 CA 2692748 CA 2692748 A CA2692748 A CA 2692748A CA 2692748 A1 CA2692748 A1 CA 2692748A1
- Authority
- CA
- Canada
- Prior art keywords
- irna
- acid
- hydrophilic
- agent
- pharmaceutical formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC(C)CCC[C@@](C)C(CC1)[C@@](C)(CC2)[C@]1(C)[C@@]1[C@@]2(C)[C@@](C)(CCC(C2)S*(CCC(NC(CCCC3)CC3P(C)(OC)=O)=O)=C)C2=CC1 Chemical compound CC(C)CCC[C@@](C)C(CC1)[C@@](C)(CC2)[C@]1(C)[C@@]1[C@@]2(C)[C@@](C)(CCC(C2)S*(CCC(NC(CCCC3)CC3P(C)(OC)=O)=O)=C)C2=CC1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94843307P | 2007-07-06 | 2007-07-06 | |
US60/948,433 | 2007-07-06 | ||
PCT/US2008/008326 WO2009009025A1 (fr) | 2007-07-06 | 2008-07-07 | Micelles mixtes renfermant des conjugués amphiphatiques d'agents arn et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2692748A1 true CA2692748A1 (fr) | 2009-01-15 |
Family
ID=40228904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2692748 Abandoned CA2692748A1 (fr) | 2007-07-06 | 2008-07-07 | Micelles mixtes renfermant des conjugues amphiphatiques d'agents arn et leurs utilisations |
Country Status (6)
Country | Link |
---|---|
US (1) | US20110008395A1 (fr) |
EP (1) | EP2171095A4 (fr) |
JP (1) | JP2010532786A (fr) |
KR (1) | KR20100037120A (fr) |
CA (1) | CA2692748A1 (fr) |
WO (1) | WO2009009025A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9339558B2 (en) | 2008-05-13 | 2016-05-17 | University Of Washington | Micellic assemblies |
AU2009246321A1 (en) | 2008-05-13 | 2009-11-19 | Phaserx, Inc. | Polymeric carrier |
BRPI0912159B8 (pt) | 2008-05-13 | 2021-05-25 | Phaserx Inc | copolímero compreendendo um primeiro bloco que compreende uma unidade hidrofílica em ph fisiológico e um segundo bloco que compreende grupos hidrofóbicos, e uso do dito copolímero para liberação intracelular de um polinucleotídeo |
JP2012500793A (ja) | 2008-08-22 | 2012-01-12 | ユニヴァーシティ オブ ワシントン | 細胞内デリバリーのための異種性ポリマーミセル |
JP2012507581A (ja) | 2008-11-06 | 2012-03-29 | ユニヴァーシティ オブ ワシントン | 二重特異性細胞内送達媒体 |
US9464300B2 (en) | 2008-11-06 | 2016-10-11 | University Of Washington | Multiblock copolymers |
EP2373715A4 (fr) | 2008-12-08 | 2014-12-03 | Univ Washington | Polymères à fonction oméga, copolymères séquencés à fonction de jonction, bioconjugués polymères et polymérisation d'extension de chaîne radicalaire |
GB0910723D0 (en) * | 2009-06-22 | 2009-08-05 | Sylentis Sau | Novel drugs for inhibition of gene expression |
US9238811B2 (en) * | 2009-07-14 | 2016-01-19 | Northeastern University | siRNA phospholipid conjugate |
US9415113B2 (en) | 2009-11-18 | 2016-08-16 | University Of Washington | Targeting monomers and polymers having targeting blocks |
CA2804815C (fr) * | 2010-07-09 | 2016-06-07 | The University Of Tokyo | Composition d'administration d'acides nucleiques, composition d'excipient, composition pharmaceutique contenant la composition d'administration d'acides nucleiques ou la composition d'excipient et methode d'administration d'acides nucleiques |
JP6190132B2 (ja) * | 2013-03-21 | 2017-08-30 | 学校法人近畿大学 | 遺伝子試料導入用基板及び遺伝子試料導入方法 |
WO2015017519A1 (fr) | 2013-07-30 | 2015-02-05 | Phaserx, Inc. | Copolymères séquencés et leur conjugués ou complexes avec des oligonucléotides |
CN107530436B (zh) | 2015-01-21 | 2022-03-29 | 菲泽尔克斯公司 | 用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统 |
MX2019002075A (es) * | 2016-08-23 | 2019-07-01 | Dicerna Pharmaceuticals Inc | Composiciones que comprenden oligonucleotidos modificados reversiblemente, y sus usos. |
US11684584B2 (en) | 2016-12-30 | 2023-06-27 | Genevant Sciences Gmbh | Branched peg molecules and related compositions and methods |
KR20210018267A (ko) | 2018-05-07 | 2021-02-17 | 알닐람 파마슈티칼스 인코포레이티드 | 간외 전달 |
WO2021054927A2 (fr) * | 2018-08-10 | 2021-03-25 | South Dakota Board Of Regents | Dérivés du glutathion-cholestérol en tant qu'agents ciblant le cerveau |
KR20230167371A (ko) | 2021-03-08 | 2023-12-08 | 익스티엘 에이피, 엘엘씨 | 탄소성 물질의 열분해 장치 및 방법 |
CN113633613B (zh) * | 2021-07-20 | 2023-04-25 | 河南大学 | 一种siRNA胶束、制备方法、组合物及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996034876A1 (fr) * | 1995-05-04 | 1996-11-07 | Nexstar Pharmaceuticals, Inc. | Complexes de ligands d'acide nucleique |
US20030147944A1 (en) * | 1999-12-10 | 2003-08-07 | Mayer Lawrence D | Lipid carrier compositions with protected surface reactive functions |
US8202979B2 (en) * | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
WO2005041859A2 (fr) * | 2003-04-30 | 2005-05-12 | Sirna Therapeutics, Inc. | Conjugues et compositions |
AU2004227414A1 (en) * | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | iRNA conjugates |
JP4597976B2 (ja) * | 2003-04-17 | 2010-12-15 | アルナイラム ファーマシューティカルズ インコーポレイテッド | 修飾iRNA剤 |
-
2008
- 2008-07-07 JP JP2010516035A patent/JP2010532786A/ja active Pending
- 2008-07-07 EP EP08826166A patent/EP2171095A4/fr not_active Withdrawn
- 2008-07-07 CA CA 2692748 patent/CA2692748A1/fr not_active Abandoned
- 2008-07-07 KR KR1020107001933A patent/KR20100037120A/ko not_active Application Discontinuation
- 2008-07-07 US US12/667,713 patent/US20110008395A1/en not_active Abandoned
- 2008-07-07 WO PCT/US2008/008326 patent/WO2009009025A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20110008395A1 (en) | 2011-01-13 |
JP2010532786A (ja) | 2010-10-14 |
EP2171095A4 (fr) | 2012-07-11 |
WO2009009025A1 (fr) | 2009-01-15 |
EP2171095A1 (fr) | 2010-04-07 |
KR20100037120A (ko) | 2010-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20110008395A1 (en) | Mixed micelles including amphipathic conjugates of rna agents, and uses thereof | |
US11492619B2 (en) | Dynamic pharmacokinetic-modifying anchors | |
Zhang et al. | Cationic lipids and polymers mediated vectors for delivery of siRNA | |
KR102689177B1 (ko) | 변형된 RNAi 제제 | |
TR201811076T4 (tr) | Geliştirilmiş lipit formulasyonu. | |
JP7536007B2 (ja) | 修飾二重鎖オリゴヌクレオチド | |
JP5865319B2 (ja) | iRNA複合体 | |
US20230061751A1 (en) | Universal dynamic pharmacokinetic-modifying anchors | |
JP2024504694A (ja) | 修飾二本鎖オリゴヌクレオチド | |
US20220389419A1 (en) | Modified oligonucleotides | |
Alameh | Gene Silencing Using Chitosan Based siRNA Delivery Systems in Cells and Animals | |
Class et al. | Inventors: Muthiah Manoharan (Cambridge, MA, US) Kallanthottathil G. Rajeev (Cambridge, MA, US) David Bumcrot (Cambridge, MA, US) | |
Kore et al. | Chemical modifications of synthetic RNAi agents and in vivo delivery techniques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |
Effective date: 20140708 |