CA2692656A1 - Procede pour la production de thrombine '644 humaine recombinante - Google Patents
Procede pour la production de thrombine '644 humaine recombinante Download PDFInfo
- Publication number
- CA2692656A1 CA2692656A1 CA 2692656 CA2692656A CA2692656A1 CA 2692656 A1 CA2692656 A1 CA 2692656A1 CA 2692656 CA2692656 CA 2692656 CA 2692656 A CA2692656 A CA 2692656A CA 2692656 A1 CA2692656 A1 CA 2692656A1
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- Prior art keywords
- recombinant
- ecarin
- prothrombin
- thrombin
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
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- Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
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- Diabetes (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94820707P | 2007-07-06 | 2007-07-06 | |
| US60/948,207 | 2007-07-06 | ||
| PCT/SE2008/050836 WO2009008821A1 (fr) | 2007-07-06 | 2008-07-04 | Procédé pour la production de thrombine '644 humaine recombinante |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2692656A1 true CA2692656A1 (fr) | 2009-01-15 |
Family
ID=40228838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2692656 Abandoned CA2692656A1 (fr) | 2007-07-06 | 2008-07-04 | Procede pour la production de thrombine '644 humaine recombinante |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8206967B2 (fr) |
| EP (1) | EP2179038B1 (fr) |
| JP (1) | JP5661459B2 (fr) |
| CN (1) | CN101688195B (fr) |
| AU (1) | AU2008275828B2 (fr) |
| BR (1) | BRPI0813743A2 (fr) |
| CA (1) | CA2692656A1 (fr) |
| WO (1) | WO2009008821A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0324044D0 (en) * | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
| PT1737889E (pt) | 2004-10-19 | 2010-12-13 | Lonza Ag | Método para síntese de péptidos em fase sólida |
| CA2602793C (fr) * | 2005-04-13 | 2016-11-22 | Astrazeneca Ab | Cellule hote a vecteur de production de proteines demandant une gamma-carboxylation |
| US8206967B2 (en) * | 2007-07-06 | 2012-06-26 | Medimmune Limited | Method for production of recombinant human thrombin |
| CN102690803B (zh) * | 2011-03-24 | 2015-04-29 | 苏州泽璟生物制药有限公司 | 一种重组人凝血酶在动物细胞内的高效表达和生产方法 |
| EP2556842A1 (fr) | 2011-08-11 | 2013-02-13 | Bioftalmik, S.L. | Composition sous la forme de film comportant une fibrinogène et activateur de fibrinogène et applications associées |
| CN107267492A (zh) * | 2017-07-10 | 2017-10-20 | 中山大学 | 一种尖吻蝮蛇凝血酶重组蛋白的表达方法 |
| WO2020229521A1 (fr) | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes pour inhiber ou réduire des biolfilms bactériens sur une surface |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE3043857A1 (de) * | 1980-11-21 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii |
| US4599308A (en) * | 1981-10-06 | 1986-07-08 | Hamer Dean H | Protein from SV40 recombinants |
| DE3584341D1 (de) * | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
| GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| WO1988003926A1 (fr) | 1986-11-17 | 1988-06-02 | New England Medical Center | Amelioration de la gamma-carboxylation de proteines recombinantes dependantes de la vitamine k |
| US6224864B1 (en) * | 1986-12-03 | 2001-05-01 | Pharmacia & Upjohn Company | Antibiotic 10381A, and process for the preparation of anitbiotics 10381B |
| EP0380508A4 (en) | 1987-05-18 | 1991-04-03 | Integrated Genetics, Inc. | Improved protein c molecules and method for making and activating same |
| US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
| CA1330302C (fr) * | 1988-01-18 | 1994-06-21 | Miroslav Rybak | Concentres des facteurs de coagulation ii, vii, ix et x, methode de preparation et mode d'utilisation |
| WO1992001795A1 (fr) | 1990-07-23 | 1992-02-06 | Zymogenetics, Inc. | Gamma-carboxylase et procedes d'utilisation |
| US5965789A (en) * | 1991-01-11 | 1999-10-12 | American Red Cross | Engineering protein posttranslational modification by PACE/furin in transgenic non-human mammals |
| US5268275A (en) | 1991-05-08 | 1993-12-07 | The University Of North Carolina At Chapel Hill | Vitamin K-dependent carboxylase |
| US5219995A (en) | 1992-07-14 | 1993-06-15 | Alpha Therapeutic Corporation | Plasma fraction purification |
| US6015686A (en) * | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US5639661A (en) * | 1994-03-23 | 1997-06-17 | The University Of Iowa Research Foundation | Genes and proteins for treating cystic fibrosis |
| DE4430204A1 (de) | 1994-08-26 | 1996-02-29 | Behringwerke Ag | Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung |
| ES2241030T3 (es) * | 1996-03-20 | 2005-10-16 | Baxter Aktiengesellschaft | Preparado farmaceutico para el tratamiento de alteraciones de la coagulacion sanguinea. |
| CA2315879A1 (fr) | 1997-12-24 | 1999-07-08 | Immunex Corporation | Adn et polypeptides v201 |
| AU5784000A (en) | 1999-07-09 | 2001-01-30 | Cohesion Technologies, Inc. | Ecarin polypeptides, polynucleotides encoding ecarin, and methods for use thereof |
| WO2001007068A1 (fr) | 1999-07-23 | 2001-02-01 | Case Western Reserve University | Nouveaux procedes et reactifs destines au traitement de l'arthrose |
| AU2001268373A1 (en) | 2000-06-13 | 2001-12-24 | The Children's Hospital Of Philadelphia | Methods for administering recombinant adeno-associated virus virions to humans previously exposed to adeno-associated virus |
| IL154880A0 (en) | 2000-10-02 | 2003-10-31 | Novo Nordisk As | Method for the production of vitamin k-dependent proteins |
| US20050164365A1 (en) | 2001-07-06 | 2005-07-28 | Juridical Foundation The Chemosero-Therapeutic Research Institute | Genetically modified ecarin and process for producing the same |
| JP4227012B2 (ja) * | 2001-07-06 | 2009-02-18 | 財団法人化学及血清療法研究所 | 遺伝子組換え技術によるヒトトロンビンの製造方法 |
| CN1254273C (zh) | 2001-07-10 | 2006-05-03 | 财团法人化学及血清疗法研究所 | 药学上稳定的止血组合物 |
| EP1670947B1 (fr) * | 2003-09-23 | 2015-04-01 | University Of North Carolina At Chapel Hill | Technique et composition de correlation de polymorphisme nucleotidique simple dans le gene vitamine k epoxyde reductase et le dosage de warfarine |
| GB0324044D0 (en) * | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
| JP4777251B2 (ja) | 2003-10-14 | 2011-09-21 | バクスター・インターナショナル・インコーポレイテッド | ビタミンｋエポキシド還元酵素複合体サブユニット１ｖｋｏｒｃ１、クマリンおよびその誘導体の治療標的 |
| EP1676911B1 (fr) | 2003-10-24 | 2010-04-21 | Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute | Nouvelles cellules animales recombinantes a production proteique elevee, procede de mise au point correspondant et procede de preparation de proteines de masse au moyen de ces cellules |
| WO2006067116A1 (fr) | 2004-12-21 | 2006-06-29 | Novo Nordisk Health Care Ag | Expression de polypeptides gamma-carboxyles dans des systemes hotes a gamma-carboxylation deficiente |
| CA2602793C (fr) * | 2005-04-13 | 2016-11-22 | Astrazeneca Ab | Cellule hote a vecteur de production de proteines demandant une gamma-carboxylation |
| US8647868B2 (en) | 2005-12-02 | 2014-02-11 | Wake Forest University Health Sciences | Compositions and methods for increasing production of recombinant gamma-carboxylated proteins |
| ES2503365T5 (es) * | 2005-12-21 | 2017-10-31 | Cnj Holdings, Inc | Método para producir proteínas dependientes de vitamina K biológicamente activas por métodos recombinantes |
| US8206967B2 (en) | 2007-07-06 | 2012-06-26 | Medimmune Limited | Method for production of recombinant human thrombin |
-
2008
- 2008-07-03 US US12/167,614 patent/US8206967B2/en not_active Expired - Fee Related
- 2008-07-04 CN CN200880023664.2A patent/CN101688195B/zh not_active Expired - Fee Related
- 2008-07-04 WO PCT/SE2008/050836 patent/WO2009008821A1/fr active Application Filing
- 2008-07-04 EP EP08779414.5A patent/EP2179038B1/fr not_active Not-in-force
- 2008-07-04 BR BRPI0813743-9A2A patent/BRPI0813743A2/pt not_active IP Right Cessation
- 2008-07-04 AU AU2008275828A patent/AU2008275828B2/en not_active Ceased
- 2008-07-04 CA CA 2692656 patent/CA2692656A1/fr not_active Abandoned
- 2008-07-04 JP JP2010514702A patent/JP5661459B2/ja not_active Expired - Fee Related
-
2012
- 2012-06-15 US US13/524,689 patent/US20120258090A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120258090A1 (en) | 2012-10-11 |
| EP2179038A4 (fr) | 2012-01-18 |
| CN101688195B (zh) | 2014-12-03 |
| BRPI0813743A2 (pt) | 2014-10-07 |
| EP2179038B1 (fr) | 2014-04-02 |
| WO2009008821A1 (fr) | 2009-01-15 |
| JP2010532661A (ja) | 2010-10-14 |
| AU2008275828A1 (en) | 2009-01-15 |
| EP2179038A1 (fr) | 2010-04-28 |
| JP5661459B2 (ja) | 2015-01-28 |
| US20090047273A1 (en) | 2009-02-19 |
| CN101688195A (zh) | 2010-03-31 |
| US8206967B2 (en) | 2012-06-26 |
| AU2008275828B2 (en) | 2012-09-27 |
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| FZDE | Discontinued |
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