CA2692546C - Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery - Google Patents

Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery Download PDF

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CA2692546C
CA2692546C CA2692546A CA2692546A CA2692546C CA 2692546 C CA2692546 C CA 2692546C CA 2692546 A CA2692546 A CA 2692546A CA 2692546 A CA2692546 A CA 2692546A CA 2692546 C CA2692546 C CA 2692546C
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nucleic acid
cationic liposome
ligand
acid molecules
viral proteins
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French (fr)
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CA2692546A1 (en
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Esther H. Chang
Kathleen F. Pirollo
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Georgetown University
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Georgetown University
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K2039/53—DNA (RNA) vaccination
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    • A—HUMAN NECESSITIES
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    • C12N2810/00—Vectors comprising a targeting moiety
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    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins

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CA2692546A 2007-07-09 2008-07-09 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery Active CA2692546C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92968507P 2007-07-09 2007-07-09
US60/929,685 2007-07-09
PCT/US2008/008394 WO2009009054A1 (en) 2007-07-09 2008-07-09 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery

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CA2692546A1 CA2692546A1 (en) 2009-01-15
CA2692546C true CA2692546C (en) 2018-03-13

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CA2692546A Active CA2692546C (en) 2007-07-09 2008-07-09 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery

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US (1) US20090053299A1 (https=)
EP (1) EP2175835B1 (https=)
JP (2) JP5890095B2 (https=)
KR (2) KR101570886B1 (https=)
CN (2) CN106890142A (https=)
AU (1) AU2008275713B2 (https=)
BR (1) BRPI0814558A2 (https=)
CA (1) CA2692546C (https=)
EA (1) EA201070050A1 (https=)
IL (1) IL203204B (https=)
MX (1) MX2010000166A (https=)
NZ (1) NZ582414A (https=)
SG (1) SG182994A1 (https=)
WO (1) WO2009009054A1 (https=)
ZA (1) ZA201000038B (https=)

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US20110182976A1 (en) * 2010-01-28 2011-07-28 National Taiwan Ocean University Lipoplex-patch based dna vaccine
WO2011105520A1 (ja) * 2010-02-26 2011-09-01 国立大学法人 長崎大学 抗原または薬物送達複合体
SI4043040T1 (sl) * 2010-08-31 2023-04-28 Glaxosmithkline Biologicals Sa Mali liposomi za dostavo imunogen-kodirajoče RNA
WO2012040101A1 (en) 2010-09-21 2012-03-29 University Of Miami Compositions and methods for inducing migration by dendritic cells and an immune response
WO2012040266A2 (en) * 2010-09-24 2012-03-29 University Of Miami Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines
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CN103405386B (zh) * 2012-09-21 2016-05-18 上海泽润生物科技有限公司 一种脂质体的制备方法及制作脂质体佐剂的方法
CA2901616A1 (en) * 2013-03-14 2014-10-02 Georgetown University Treatment for exposure to nerve agent
CN105726485B (zh) * 2016-03-24 2019-08-06 东华大学 一种半乳糖化壳聚糖修饰的免疫醇质体的制备方法
WO2020117715A1 (en) 2018-12-03 2020-06-11 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment
CN111840538A (zh) * 2020-05-29 2020-10-30 中山大学 一种水痘-带状疱疹病毒亚单位纳米疫苗的制备方法和应用
CN117883382B (zh) * 2023-11-27 2025-02-14 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 高效递送疫苗的脂质体载体及脂质体疫苗的制备与用途

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