CA2684749C - Use of adenosine deaminase for cancer therapy - Google Patents
Use of adenosine deaminase for cancer therapy Download PDFInfo
- Publication number
- CA2684749C CA2684749C CA2684749A CA2684749A CA2684749C CA 2684749 C CA2684749 C CA 2684749C CA 2684749 A CA2684749 A CA 2684749A CA 2684749 A CA2684749 A CA 2684749A CA 2684749 C CA2684749 C CA 2684749C
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- Prior art keywords
- adenosine deaminase
- tumor
- ada
- adenosine
- cancer
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Classifications
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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- C12Y—ENZYMES
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Landscapes
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| CA2684749A1 CA2684749A1 (en) | 2008-10-30 |
| CA2684749C true CA2684749C (en) | 2016-06-21 |
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| PT (1) | PT2147122E (enExample) |
| SI (1) | SI2147122T1 (enExample) |
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| WO (1) | WO2008131163A1 (enExample) |
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| ES2503765T3 (es) | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| HRP20160482T1 (hr) | 2007-04-20 | 2016-06-03 | Sigma-Tau Rare Disease Ltd | Stabilna rekombinantna adenozin deaminaza |
| EP2670850B1 (en) * | 2011-02-03 | 2016-10-26 | Mirna Therapeutics, Inc. | Synthetic mimics of mir-34 |
| EA201700181A1 (ru) | 2014-10-14 | 2017-09-29 | Галозим, Инк. | Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования |
| WO2016191283A2 (en) * | 2015-05-22 | 2016-12-01 | University Of Houston System | Enzymatic immunomodulation of solid tumors and user thereof |
| CA3056071A1 (en) * | 2016-03-11 | 2017-09-14 | University Of Louisville Research Foundation, Inc. | Methods and compositions for treating tumors |
| JP2020516654A (ja) | 2017-04-13 | 2020-06-11 | センティ バイオサイエンシズ インコーポレイテッド | 組み合わせがん免疫療法 |
| US10993967B2 (en) | 2018-10-17 | 2021-05-04 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| WO2023086931A2 (en) * | 2021-11-12 | 2023-05-19 | Georgia Tech Research Corporation | Adenosine deaminase 1 compositions and methods for using same |
| US20240250753A1 (en) * | 2022-10-10 | 2024-07-25 | Berkeley Marine Robotics Inc. | Ship Hull Inspection using a Swarm of Unmanned Underwater Vehicles equipped with Wireless Laser Systems |
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| US5346823A (en) * | 1984-05-29 | 1994-09-13 | Genencor, Inc. | Subtilisin modifications to enhance oxidative stability |
| US5324844A (en) * | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5349001A (en) * | 1993-01-19 | 1994-09-20 | Enzon, Inc. | Cyclic imide thione activated polyalkylene oxides |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5605976A (en) * | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5730990A (en) * | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
| US5756593A (en) * | 1995-05-15 | 1998-05-26 | Enzon, Inc. | Method of preparing polyalkyene oxide carboxylic acids |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| WO1999030727A1 (en) * | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6624142B2 (en) * | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6824766B2 (en) * | 1998-04-17 | 2004-11-30 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6333396B1 (en) * | 1998-10-20 | 2001-12-25 | Enzon, Inc. | Method for targeted delivery of nucleic acids |
| US20020088017A1 (en) * | 1999-04-28 | 2002-07-04 | Board Of Regents, The University Of Texas System | Adenosine deaminase deficient transgenic mice and methods for the use thereof |
| US6579857B1 (en) * | 1999-06-11 | 2003-06-17 | Evanston Northwestern Healthcare Research Institute | Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors |
| AU7868400A (en) | 1999-10-08 | 2001-04-23 | Alza Corporation | Neutral-cationic lipid for nucleic acid and drug delivery |
| WO2002077233A2 (en) * | 2000-11-08 | 2002-10-03 | Millennium Pharmaceuticals, Inc. | 38650, 28472, 5495, 65507, 81588 and 14354 METHODS AND COMPOSITIONS OF HUMAN PROTEINS AND USES THEREOF |
| US20040105839A1 (en) * | 2001-11-28 | 2004-06-03 | Myung-Ok Park | Biologically active non-antigenic copolymer and conjugates thereof and methods for producing the same |
| CA2470104C (en) | 2001-12-12 | 2015-01-27 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US20040175804A1 (en) * | 2003-03-04 | 2004-09-09 | Skonezny Paul M. | Process for preparing dideoxyinosine using adenosine deaminase enzyme |
| US7301003B2 (en) * | 2005-08-26 | 2007-11-27 | Enzon Pharmaceuticals, Inc. | Method of preparing polymers having terminal amine groups |
| US7601798B2 (en) * | 2005-10-04 | 2009-10-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing polymers having terminal amine groups using protected amine salts |
| US7989554B2 (en) * | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
| JP2010500963A (ja) | 2006-06-21 | 2010-01-14 | エンゾン ファーマスーティカルズ インコーポレイテッド | 安定化タンパク質 |
| JP2010503705A (ja) | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | ヒンダードエステル系の生分解性リンカーを有するポリアルキレンオキサイド |
| EP2117528A4 (en) * | 2006-12-29 | 2013-01-02 | Sigma Tau Rare Diseases S A | USE OF ADENOSINE DEAMINASE FOR THE TREATMENT OF LUNG DISEASES |
| HRP20160482T1 (hr) | 2007-04-20 | 2016-06-03 | Sigma-Tau Rare Disease Ltd | Stabilna rekombinantna adenozin deaminaza |
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| EP2147122A1 (en) | 2010-01-27 |
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| TWI486169B (zh) | 2015-06-01 |
| NZ580980A (en) | 2012-04-27 |
| JP5595904B2 (ja) | 2014-09-24 |
| CN101680039A (zh) | 2010-03-24 |
| SI2147122T1 (sl) | 2015-01-30 |
| PT2147122E (pt) | 2014-10-15 |
| KR101540296B1 (ko) | 2015-07-31 |
| US8741283B2 (en) | 2014-06-03 |
| BRPI0810384A2 (pt) | 2014-11-04 |
| JP2010524968A (ja) | 2010-07-22 |
| TW200902051A (en) | 2009-01-16 |
| WO2008131163A1 (en) | 2008-10-30 |
| BRPI0810384B8 (pt) | 2021-05-25 |
| KR20090130108A (ko) | 2009-12-17 |
| US20090047270A1 (en) | 2009-02-19 |
| PL2147122T3 (pl) | 2015-05-29 |
| EP2147122A4 (en) | 2010-11-17 |
| EP2147122B1 (en) | 2014-07-16 |
| HRP20140947T1 (hr) | 2015-02-13 |
| CN101680039B (zh) | 2016-08-24 |
| CY1117000T1 (el) | 2017-04-05 |
| RU2009142817A (ru) | 2011-05-27 |
| WO2008131163A8 (en) | 2010-01-28 |
| IL201593A0 (en) | 2010-05-31 |
| MX2009011320A (es) | 2009-12-15 |
| BRPI0810384B1 (pt) | 2021-02-02 |
| AU2008242791A1 (en) | 2008-10-30 |
| IL201593A (en) | 2017-07-31 |
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