BRPI0810384B8 - terapia enzimática anticâncer - Google Patents
terapia enzimática anticâncerInfo
- Publication number
- BRPI0810384B8 BRPI0810384B8 BRPI0810384A BRPI0810384A BRPI0810384B8 BR PI0810384 B8 BRPI0810384 B8 BR PI0810384B8 BR PI0810384 A BRPI0810384 A BR PI0810384A BR PI0810384 A BRPI0810384 A BR PI0810384A BR PI0810384 B8 BRPI0810384 B8 BR PI0810384B8
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme therapy
- anticancer
- anticancer enzyme
- patient
- therapy
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 230000001093 anti-cancer Effects 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 abstract 1
- 102000055025 Adenosine deaminases Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04004—Adenosine deaminase (3.5.4.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91303907P | 2007-04-20 | 2007-04-20 | |
| US60/913,039 | 2007-04-20 | ||
| PCT/US2008/060733 WO2008131163A1 (en) | 2007-04-20 | 2008-04-18 | Enzymatic anticancer therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0810384A2 BRPI0810384A2 (pt) | 2014-11-04 |
| BRPI0810384B1 BRPI0810384B1 (pt) | 2021-02-02 |
| BRPI0810384B8 true BRPI0810384B8 (pt) | 2021-05-25 |
Family
ID=39875909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0810384A BRPI0810384B8 (pt) | 2007-04-20 | 2008-04-18 | terapia enzimática anticâncer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8741283B2 (enExample) |
| EP (1) | EP2147122B1 (enExample) |
| JP (1) | JP5595904B2 (enExample) |
| KR (1) | KR101540296B1 (enExample) |
| CN (1) | CN101680039B (enExample) |
| BR (1) | BRPI0810384B8 (enExample) |
| CA (1) | CA2684749C (enExample) |
| CY (1) | CY1117000T1 (enExample) |
| DK (1) | DK2147122T3 (enExample) |
| ES (1) | ES2507508T3 (enExample) |
| HR (1) | HRP20140947T1 (enExample) |
| IL (1) | IL201593A (enExample) |
| MX (1) | MX2009011320A (enExample) |
| NZ (1) | NZ580980A (enExample) |
| PL (1) | PL2147122T3 (enExample) |
| PT (1) | PT2147122E (enExample) |
| SI (1) | SI2147122T1 (enExample) |
| TW (1) | TWI486169B (enExample) |
| WO (1) | WO2008131163A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2503765T3 (es) | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| HRP20160482T1 (hr) | 2007-04-20 | 2016-06-03 | Sigma-Tau Rare Disease Ltd | Stabilna rekombinantna adenozin deaminaza |
| EP2670850B1 (en) * | 2011-02-03 | 2016-10-26 | Mirna Therapeutics, Inc. | Synthetic mimics of mir-34 |
| EA201700181A1 (ru) | 2014-10-14 | 2017-09-29 | Галозим, Инк. | Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования |
| WO2016191283A2 (en) * | 2015-05-22 | 2016-12-01 | University Of Houston System | Enzymatic immunomodulation of solid tumors and user thereof |
| CA3056071A1 (en) * | 2016-03-11 | 2017-09-14 | University Of Louisville Research Foundation, Inc. | Methods and compositions for treating tumors |
| JP2020516654A (ja) | 2017-04-13 | 2020-06-11 | センティ バイオサイエンシズ インコーポレイテッド | 組み合わせがん免疫療法 |
| US10993967B2 (en) | 2018-10-17 | 2021-05-04 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| WO2023086931A2 (en) * | 2021-11-12 | 2023-05-19 | Georgia Tech Research Corporation | Adenosine deaminase 1 compositions and methods for using same |
| US20240250753A1 (en) * | 2022-10-10 | 2024-07-25 | Berkeley Marine Robotics Inc. | Ship Hull Inspection using a Swarm of Unmanned Underwater Vehicles equipped with Wireless Laser Systems |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5346823A (en) * | 1984-05-29 | 1994-09-13 | Genencor, Inc. | Subtilisin modifications to enhance oxidative stability |
| US5324844A (en) * | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5349001A (en) * | 1993-01-19 | 1994-09-20 | Enzon, Inc. | Cyclic imide thione activated polyalkylene oxides |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5605976A (en) * | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5730990A (en) * | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
| US5756593A (en) * | 1995-05-15 | 1998-05-26 | Enzon, Inc. | Method of preparing polyalkyene oxide carboxylic acids |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| WO1999030727A1 (en) * | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6624142B2 (en) * | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US5965119A (en) * | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6824766B2 (en) * | 1998-04-17 | 2004-11-30 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6333396B1 (en) * | 1998-10-20 | 2001-12-25 | Enzon, Inc. | Method for targeted delivery of nucleic acids |
| US20020088017A1 (en) * | 1999-04-28 | 2002-07-04 | Board Of Regents, The University Of Texas System | Adenosine deaminase deficient transgenic mice and methods for the use thereof |
| US6579857B1 (en) * | 1999-06-11 | 2003-06-17 | Evanston Northwestern Healthcare Research Institute | Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors |
| AU7868400A (en) | 1999-10-08 | 2001-04-23 | Alza Corporation | Neutral-cationic lipid for nucleic acid and drug delivery |
| WO2002077233A2 (en) * | 2000-11-08 | 2002-10-03 | Millennium Pharmaceuticals, Inc. | 38650, 28472, 5495, 65507, 81588 and 14354 METHODS AND COMPOSITIONS OF HUMAN PROTEINS AND USES THEREOF |
| US20040105839A1 (en) * | 2001-11-28 | 2004-06-03 | Myung-Ok Park | Biologically active non-antigenic copolymer and conjugates thereof and methods for producing the same |
| CA2470104C (en) | 2001-12-12 | 2015-01-27 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US20040175804A1 (en) * | 2003-03-04 | 2004-09-09 | Skonezny Paul M. | Process for preparing dideoxyinosine using adenosine deaminase enzyme |
| US7301003B2 (en) * | 2005-08-26 | 2007-11-27 | Enzon Pharmaceuticals, Inc. | Method of preparing polymers having terminal amine groups |
| US7601798B2 (en) * | 2005-10-04 | 2009-10-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing polymers having terminal amine groups using protected amine salts |
| US7989554B2 (en) * | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
| JP2010500963A (ja) | 2006-06-21 | 2010-01-14 | エンゾン ファーマスーティカルズ インコーポレイテッド | 安定化タンパク質 |
| JP2010503705A (ja) | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | ヒンダードエステル系の生分解性リンカーを有するポリアルキレンオキサイド |
| EP2117528A4 (en) * | 2006-12-29 | 2013-01-02 | Sigma Tau Rare Diseases S A | USE OF ADENOSINE DEAMINASE FOR THE TREATMENT OF LUNG DISEASES |
| HRP20160482T1 (hr) | 2007-04-20 | 2016-06-03 | Sigma-Tau Rare Disease Ltd | Stabilna rekombinantna adenozin deaminaza |
-
2008
- 2008-04-18 BR BRPI0810384A patent/BRPI0810384B8/pt active IP Right Grant
- 2008-04-18 CN CN200880021105.8A patent/CN101680039B/zh active Active
- 2008-04-18 NZ NZ580980A patent/NZ580980A/en unknown
- 2008-04-18 HR HRP20140947AT patent/HRP20140947T1/hr unknown
- 2008-04-18 MX MX2009011320A patent/MX2009011320A/es active IP Right Grant
- 2008-04-18 EP EP08754910.1A patent/EP2147122B1/en active Active
- 2008-04-18 US US12/105,682 patent/US8741283B2/en active Active
- 2008-04-18 WO PCT/US2008/060733 patent/WO2008131163A1/en not_active Ceased
- 2008-04-18 DK DK08754910.1T patent/DK2147122T3/da active
- 2008-04-18 CA CA2684749A patent/CA2684749C/en not_active Expired - Fee Related
- 2008-04-18 PL PL08754910T patent/PL2147122T3/pl unknown
- 2008-04-18 SI SI200831301T patent/SI2147122T1/sl unknown
- 2008-04-18 TW TW097114405A patent/TWI486169B/zh active
- 2008-04-18 JP JP2010504262A patent/JP5595904B2/ja active Active
- 2008-04-18 PT PT87549101T patent/PT2147122E/pt unknown
- 2008-04-18 ES ES08754910.1T patent/ES2507508T3/es active Active
- 2008-04-18 KR KR1020097023239A patent/KR101540296B1/ko active Active
-
2009
- 2009-10-18 IL IL201593A patent/IL201593A/en active IP Right Grant
-
2014
- 2014-10-03 CY CY20141100797T patent/CY1117000T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2147122T3 (da) | 2014-10-13 |
| CA2684749A1 (en) | 2008-10-30 |
| EP2147122A1 (en) | 2010-01-27 |
| ES2507508T3 (es) | 2014-10-15 |
| TWI486169B (zh) | 2015-06-01 |
| NZ580980A (en) | 2012-04-27 |
| JP5595904B2 (ja) | 2014-09-24 |
| CN101680039A (zh) | 2010-03-24 |
| SI2147122T1 (sl) | 2015-01-30 |
| PT2147122E (pt) | 2014-10-15 |
| KR101540296B1 (ko) | 2015-07-31 |
| US8741283B2 (en) | 2014-06-03 |
| BRPI0810384A2 (pt) | 2014-11-04 |
| JP2010524968A (ja) | 2010-07-22 |
| TW200902051A (en) | 2009-01-16 |
| WO2008131163A1 (en) | 2008-10-30 |
| KR20090130108A (ko) | 2009-12-17 |
| US20090047270A1 (en) | 2009-02-19 |
| PL2147122T3 (pl) | 2015-05-29 |
| EP2147122A4 (en) | 2010-11-17 |
| EP2147122B1 (en) | 2014-07-16 |
| HRP20140947T1 (hr) | 2015-02-13 |
| CN101680039B (zh) | 2016-08-24 |
| CY1117000T1 (el) | 2017-04-05 |
| RU2009142817A (ru) | 2011-05-27 |
| WO2008131163A8 (en) | 2010-01-28 |
| IL201593A0 (en) | 2010-05-31 |
| MX2009011320A (es) | 2009-12-15 |
| CA2684749C (en) | 2016-06-21 |
| BRPI0810384B1 (pt) | 2021-02-02 |
| AU2008242791A1 (en) | 2008-10-30 |
| IL201593A (en) | 2017-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: DEFIANTE FARMACEUTICA, S.A. (PT) |
|
| B25A | Requested transfer of rights approved |
Owner name: SIGMA-TAU RARE DISEASES, S.A. (PT) |
|
| B25A | Requested transfer of rights approved |
Owner name: SIGMA-TAU PHARMA LIMITED (GB) |
|
| B25A | Requested transfer of rights approved |
Owner name: SIGMA-TAU RARE DISEASE LTD. (GB) |
|
| B25D | Requested change of name of applicant approved |
Owner name: LEADIANT BIOSCIENCES LIMITED (GB) |
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