CA2684594C - Benzimidazoles and pharmaceutical compositions thereof for treating mycobacterium tuberculosis or francisella tulerensis infection - Google Patents

Benzimidazoles and pharmaceutical compositions thereof for treating mycobacterium tuberculosis or francisella tulerensis infection Download PDF

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Publication number
CA2684594C
CA2684594C CA2684594A CA2684594A CA2684594C CA 2684594 C CA2684594 C CA 2684594C CA 2684594 A CA2684594 A CA 2684594A CA 2684594 A CA2684594 A CA 2684594A CA 2684594 C CA2684594 C CA 2684594C
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Canada
Prior art keywords
aryl
cycloalkyl
alkyl
heterocyclic
halo
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Application number
CA2684594A
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English (en)
French (fr)
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CA2684594A1 (en
Inventor
Iwao Ojima
Seung-Yub Lee
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Research Foundation of the State University of New York
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Publication of CA2684594A1 publication Critical patent/CA2684594A1/en
Application granted granted Critical
Publication of CA2684594C publication Critical patent/CA2684594C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2684594A 2007-04-20 2008-04-21 Benzimidazoles and pharmaceutical compositions thereof for treating mycobacterium tuberculosis or francisella tulerensis infection Active CA2684594C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91298007P 2007-04-20 2007-04-20
US60/912,980 2007-04-20
PCT/US2008/005084 WO2008130669A1 (en) 2007-04-20 2008-04-21 Benzimidazoles and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
CA2684594A1 CA2684594A1 (en) 2008-10-30
CA2684594C true CA2684594C (en) 2015-10-06

Family

ID=39875833

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2684594A Active CA2684594C (en) 2007-04-20 2008-04-21 Benzimidazoles and pharmaceutical compositions thereof for treating mycobacterium tuberculosis or francisella tulerensis infection

Country Status (17)

Country Link
US (1) US8232410B2 (https=)
EP (1) EP2154966B1 (https=)
JP (1) JP5400032B2 (https=)
CN (1) CN101677553A (https=)
AU (1) AU2008242488B2 (https=)
BR (1) BRPI0810244A2 (https=)
CA (1) CA2684594C (https=)
DK (1) DK2154966T3 (https=)
EA (1) EA016726B1 (https=)
ES (1) ES2434693T3 (https=)
HR (1) HRP20131103T1 (https=)
IN (1) IN2009KN03959A (https=)
MX (1) MX2009011281A (https=)
PL (1) PL2154966T3 (https=)
PT (1) PT2154966E (https=)
SI (1) SI2154966T1 (https=)
WO (1) WO2008130669A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232310B2 (en) 2006-12-29 2012-07-31 Georgetown University Targeting of EWS-FLI1 as anti-tumor therapy
US8039502B2 (en) 2007-07-24 2011-10-18 The Ohio State University Research Foundation Anti-infective agents against intracellular pathogens
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2013116823A1 (en) * 2012-02-02 2013-08-08 The Research Foundation Of State University Of New York Benzimidazoles and uses thereof
WO2013142326A1 (en) * 2012-03-23 2013-09-26 The Research Foundation Of State University Of New York 5-carbonylamino-/(sulfonamido-) substituted benz imidazoles and use thereof treatment of tuberculosis
CN107011242B (zh) * 2012-04-12 2020-08-07 乔治城大学 用于治疗尤文肉瘤家族肿瘤的方法和组合物
CN103333170B (zh) * 2013-06-14 2016-08-10 清华大学 苯并咪唑类化合物及其用途
AU2014340398A1 (en) 2013-10-24 2016-06-09 Georgetown University Methods and compositions for treating cancer
WO2015077276A1 (en) 2013-11-22 2015-05-28 The Research Foundation For The State University Of New York Benzimidazoles and their use in the treatment of tuberculosis
US10287617B2 (en) 2014-03-11 2019-05-14 Colorado State University Research Foundation Methods for in vitro—in vivo efficacy determination
WO2015193506A1 (en) * 2014-06-20 2015-12-23 Institut Pasteur Korea Anti-infective compounds
CN107108580B (zh) 2014-10-09 2020-06-30 英克特诺治疗公司 吲哚酮化合物及其用途
EP3795563B1 (en) 2016-03-31 2024-07-17 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
CA3029851A1 (en) 2016-07-29 2018-02-01 Oncternal Therapeutics, Inc. Uses of indoline compounds such as tk216 for the treatment of cancer
CN111303092B (zh) * 2020-04-07 2021-05-25 山东昌邑灶户盐化有限公司 2,4-二硝基-6-氯苯胺衍生物、合成方法及其应用
KR20240035820A (ko) 2021-07-09 2024-03-18 플렉시움 인코포레이티드 Ikzf2를 조절하는 아릴 화합물 및 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61170732A (ja) * 1985-01-25 1986-08-01 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US7405235B2 (en) * 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
EP1805147B1 (en) * 2004-09-30 2014-08-13 Janssen Pharmaceutica NV Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
EP2008210A1 (en) 2006-03-15 2008-12-31 Csir Modulation of phosphoryl transferase activity of glutamine synthetase

Also Published As

Publication number Publication date
US20100256203A1 (en) 2010-10-07
PL2154966T3 (pl) 2014-03-31
JP5400032B2 (ja) 2014-01-29
CN101677553A (zh) 2010-03-24
IN2009KN03959A (https=) 2015-08-28
MX2009011281A (es) 2010-03-08
EP2154966A1 (en) 2010-02-24
EP2154966B1 (en) 2013-08-21
EA016726B1 (ru) 2012-07-30
AU2008242488A1 (en) 2008-10-30
ES2434693T3 (es) 2013-12-17
JP2010524947A (ja) 2010-07-22
AU2008242488B2 (en) 2014-10-30
BRPI0810244A2 (pt) 2014-09-30
PT2154966E (pt) 2013-11-13
EP2154966A4 (en) 2010-12-15
CA2684594A1 (en) 2008-10-30
US8232410B2 (en) 2012-07-31
SI2154966T1 (sl) 2014-02-28
WO2008130669A1 (en) 2008-10-30
EA200901423A1 (ru) 2010-06-30
HRP20131103T1 (hr) 2013-12-20
DK2154966T3 (da) 2013-11-18

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