CA2682994A1 - Composes heterocycliques presentant une affinite pour les recepteurs muscariniques - Google Patents

Composes heterocycliques presentant une affinite pour les recepteurs muscariniques Download PDF

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Publication number
CA2682994A1
CA2682994A1 CA002682994A CA2682994A CA2682994A1 CA 2682994 A1 CA2682994 A1 CA 2682994A1 CA 002682994 A CA002682994 A CA 002682994A CA 2682994 A CA2682994 A CA 2682994A CA 2682994 A1 CA2682994 A1 CA 2682994A1
Authority
CA
Canada
Prior art keywords
pyrazol
compound
tetrahydro
methylpyridine
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002682994A
Other languages
English (en)
Inventor
Axel Stoit
Hein K.A.C. Coolen
Cornelis G. Kruse
Jan H. Reinders (Deceased)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Healthcare Products BV
Original Assignee
Solvay Pharmaceuticals B.V.
Axel Stoit
Hein K.A.C. Coolen
Cornelis G. Kruse
Jan H. Reinders (Deceased)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals B.V., Axel Stoit, Hein K.A.C. Coolen, Cornelis G. Kruse, Jan H. Reinders (Deceased) filed Critical Solvay Pharmaceuticals B.V.
Publication of CA2682994A1 publication Critical patent/CA2682994A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002682994A 2007-04-24 2008-04-23 Composes heterocycliques presentant une affinite pour les recepteurs muscariniques Abandoned CA2682994A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US91358407P 2007-04-24 2007-04-24
EP07106814.2 2007-04-24
EP07106814 2007-04-24
US60/913,584 2007-04-24
PCT/EP2008/054897 WO2008129054A2 (fr) 2007-04-24 2008-04-23 Composés hétérocycliques présentant une affinité pour les récepteurs muscariniques

Publications (1)

Publication Number Publication Date
CA2682994A1 true CA2682994A1 (fr) 2008-10-30

Family

ID=38510408

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002682994A Abandoned CA2682994A1 (fr) 2007-04-24 2008-04-23 Composes heterocycliques presentant une affinite pour les recepteurs muscariniques

Country Status (8)

Country Link
EP (1) EP2150543A2 (fr)
JP (1) JP2010525020A (fr)
CN (1) CN101939311A (fr)
AU (1) AU2008240704A1 (fr)
CA (1) CA2682994A1 (fr)
MX (1) MX2009011499A (fr)
RU (1) RU2446166C2 (fr)
WO (1) WO2008129054A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8084473B2 (en) 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
EP2427432A2 (fr) * 2009-05-07 2012-03-14 Torrent Pharmaceuticals Limited Nouveaux composés hétérocycliques
ES2603032T3 (es) 2010-07-15 2017-02-23 Bayer Intellectual Property Gmbh Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas
BR112015004427A2 (pt) * 2012-10-26 2017-07-04 Hoffmann La Roche compostos , métodos para o tratamento de um estado inflamatório , da artrite reumatóide , da asma , de um distúrbio imunológico e de um distúrbio imune e composição farmacêutica
AR121893A1 (es) 2020-04-22 2022-07-20 Sumitomo Chemical Co Compuesto de fenilo y método para controlar enfermedades vegetales

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
WO1999062885A1 (fr) * 1998-06-05 1999-12-09 Boehringer Ingelheim Pharmaceuticals, Inc. 1-(4-aminophenyl) pyrazoles substitues et leur utilisation en tant qu'agents anti-inflammatoires
EP1438309A1 (fr) * 2001-10-17 2004-07-21 Ucb, S.A. Derives de quinuclidine, leurs procedes de preparation, et leurs utilisations en tant qu'inhibiteurs de recepteur muscarinique m2 et/ou m3
US6861440B2 (en) * 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
EP1836188A1 (fr) * 2004-12-30 2007-09-26 Astex Therapeutics Limited Derives pyrazoliques modulant l'activite des kinases cdk, gsk et aurora

Also Published As

Publication number Publication date
RU2446166C2 (ru) 2012-03-27
MX2009011499A (es) 2009-11-09
WO2008129054A3 (fr) 2009-02-05
EP2150543A2 (fr) 2010-02-10
AU2008240704A1 (en) 2008-10-30
JP2010525020A (ja) 2010-07-22
WO2008129054A2 (fr) 2008-10-30
CN101939311A (zh) 2011-01-05
RU2009143353A (ru) 2011-05-27

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20140423