CA2681351A1 - Inhibitors of fibroblast activation protein, and methods of use thereof - Google Patents

Inhibitors of fibroblast activation protein, and methods of use thereof Download PDF

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Publication number
CA2681351A1
CA2681351A1 CA002681351A CA2681351A CA2681351A1 CA 2681351 A1 CA2681351 A1 CA 2681351A1 CA 002681351 A CA002681351 A CA 002681351A CA 2681351 A CA2681351 A CA 2681351A CA 2681351 A1 CA2681351 A1 CA 2681351A1
Authority
CA
Canada
Prior art keywords
compound
amino acid
carbonyl
acid residue
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002681351A
Other languages
English (en)
French (fr)
Inventor
William W. Bachovchin
Hung-Sen Lai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2681351A1 publication Critical patent/CA2681351A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002681351A 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof Abandoned CA2681351A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89578707P 2007-03-20 2007-03-20
US60/895,787 2007-03-20
PCT/US2008/057636 WO2008116054A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2681351A1 true CA2681351A1 (en) 2008-09-25

Family

ID=39766448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002681351A Abandoned CA2681351A1 (en) 2007-03-20 2008-03-20 Inhibitors of fibroblast activation protein, and methods of use thereof

Country Status (6)

Country Link
US (1) US20100105753A1 (enrdf_load_stackoverflow)
EP (1) EP2139337A4 (enrdf_load_stackoverflow)
JP (1) JP2010523477A (enrdf_load_stackoverflow)
AU (1) AU2008228863A1 (enrdf_load_stackoverflow)
CA (1) CA2681351A1 (enrdf_load_stackoverflow)
WO (1) WO2008116054A1 (enrdf_load_stackoverflow)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2389176A4 (en) * 2009-01-23 2012-08-01 Univ Sydney NEW THERAPY FOR METABOLISM DISEASE
US9120818B2 (en) * 2010-12-14 2015-09-01 Merck Sharp & Dohme Corp. Process and intermediates for preparing macrolactams
DK2753334T3 (da) 2011-08-30 2022-11-07 Tufts College Fap-aktiverede proteasomhæmmere til behandling af solide tumorer
US9284337B2 (en) 2011-11-22 2016-03-15 Trustees Of Tufts College Small molecule enhancer for dendritic cell cancer vaccines
US20200237936A1 (en) 2016-12-14 2020-07-30 Purdue Research Foundation Fibroblast activation protein (fap)-targeted imaging and therapy
CA3145340A1 (en) 2019-07-08 2021-01-14 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
KR20220032078A (ko) 2019-07-08 2022-03-15 쓰리비 파마슈티컬스 게엠베하 섬유모세포 활성화 단백질 리간드를 포함하는 화합물 및 그의 용도
EP3763726A1 (en) 2019-07-08 2021-01-13 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
CA3176497A1 (en) 2020-05-07 2021-11-11 Fatima MECHTA-GRIGORIOU Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy
WO2022148843A1 (en) 2021-01-07 2022-07-14 3B Pharmaceuticals Gmbh Compounds comprising a fibroblast activation protein ligand and use thereof
EP4050018A1 (en) 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
CN114316136B (zh) * 2022-01-13 2023-01-31 西华师范大学 一种氢键增强型水合物抑制剂及其制备方法
WO2024044765A2 (en) * 2022-08-25 2024-02-29 The Regents Of The University Of California Fibroblast activation protein alpha-cleavable pro-peptides and methods of use
WO2025046043A1 (en) 2023-08-31 2025-03-06 Stichting Radboud Universitair Medisch Centrum Endometriosis tracer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1520582A3 (en) * 1998-02-02 2009-07-01 Trustees Of Tufts College Use of dipeptidylpetidase inhibitors to regulate glucose metabolism
US6890904B1 (en) * 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US7041696B2 (en) * 2002-06-17 2006-05-09 The Procter & Gamble Company Interleukin-1β converting enzyme inhibitors
AU2006339348B2 (en) * 2005-12-19 2013-01-17 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof

Also Published As

Publication number Publication date
US20100105753A1 (en) 2010-04-29
AU2008228863A1 (en) 2008-09-25
WO2008116054A1 (en) 2008-09-25
JP2010523477A (ja) 2010-07-15
EP2139337A1 (en) 2010-01-06
EP2139337A4 (en) 2012-09-19

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140320