CA2680239A1 - Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors - Google Patents
Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors Download PDFInfo
- Publication number
- CA2680239A1 CA2680239A1 CA002680239A CA2680239A CA2680239A1 CA 2680239 A1 CA2680239 A1 CA 2680239A1 CA 002680239 A CA002680239 A CA 002680239A CA 2680239 A CA2680239 A CA 2680239A CA 2680239 A1 CA2680239 A1 CA 2680239A1
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- Prior art keywords
- compound
- group
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- groups
- alkyl
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 285
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- 125000000217 alkyl group Chemical group 0.000 claims description 44
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 42
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 25
- 125000000623 heterocyclic group Chemical group 0.000 claims description 25
- 125000003118 aryl group Chemical group 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 21
- 125000001072 heteroaryl group Chemical group 0.000 claims description 20
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 12
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- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 11
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 11
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 10
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07104393A EP1972617A1 (en) | 2007-03-19 | 2007-03-19 | Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors |
| EP07104393.9 | 2007-03-19 | ||
| PCT/EP2008/053078 WO2008113756A2 (en) | 2007-03-19 | 2008-03-14 | Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2680239A1 true CA2680239A1 (en) | 2008-09-25 |
Family
ID=38626433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002680239A Abandoned CA2680239A1 (en) | 2007-03-19 | 2008-03-14 | Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8329751B2 (enExample) |
| EP (2) | EP1972617A1 (enExample) |
| JP (1) | JP2010521529A (enExample) |
| KR (1) | KR20090121329A (enExample) |
| CN (1) | CN101610997A (enExample) |
| AU (1) | AU2008228260B2 (enExample) |
| CA (1) | CA2680239A1 (enExample) |
| IL (1) | IL200951A0 (enExample) |
| MX (1) | MX2009009409A (enExample) |
| RU (1) | RU2488580C2 (enExample) |
| WO (1) | WO2008113756A2 (enExample) |
| ZA (1) | ZA200905263B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2149568A1 (en) | 2008-07-22 | 2010-02-03 | Bracco Imaging S.p.A | Aryl-sulphonamidic dimers as metalloproteases inhibitors |
| EP2147684A1 (en) * | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| US20240207415A1 (en) | 2022-11-08 | 2024-06-27 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5058026A (enExample) * | 1973-09-26 | 1975-05-20 | ||
| IL137465A0 (en) * | 1998-02-04 | 2001-07-24 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| HUP0102196A3 (en) * | 1998-04-03 | 2002-12-28 | Sankyo Company Ltd Chuo Ku | Sulfonamide derivatives |
| WO2006101828A1 (en) * | 2005-03-15 | 2006-09-28 | Bayer Cropscience Ag | Insecticidal alkylamino phenyl sulfonamide derivatives |
-
2007
- 2007-03-19 EP EP07104393A patent/EP1972617A1/en not_active Withdrawn
-
2008
- 2008-03-14 KR KR1020097019222A patent/KR20090121329A/ko not_active Ceased
- 2008-03-14 RU RU2009138346/04A patent/RU2488580C2/ru not_active IP Right Cessation
- 2008-03-14 CN CNA200880004727XA patent/CN101610997A/zh active Pending
- 2008-03-14 EP EP08717820A patent/EP2121590A2/en not_active Withdrawn
- 2008-03-14 MX MX2009009409A patent/MX2009009409A/es active IP Right Grant
- 2008-03-14 WO PCT/EP2008/053078 patent/WO2008113756A2/en not_active Ceased
- 2008-03-14 JP JP2010500190A patent/JP2010521529A/ja active Pending
- 2008-03-14 CA CA002680239A patent/CA2680239A1/en not_active Abandoned
- 2008-03-14 AU AU2008228260A patent/AU2008228260B2/en not_active Ceased
- 2008-03-14 US US12/531,119 patent/US8329751B2/en not_active Expired - Fee Related
-
2009
- 2009-07-05 ZA ZA200905263A patent/ZA200905263B/xx unknown
- 2009-09-15 IL IL200951A patent/IL200951A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008113756A2 (en) | 2008-09-25 |
| CN101610997A (zh) | 2009-12-23 |
| WO2008113756A8 (en) | 2008-11-06 |
| RU2488580C2 (ru) | 2013-07-27 |
| ZA200905263B (en) | 2010-06-30 |
| US8329751B2 (en) | 2012-12-11 |
| RU2009138346A (ru) | 2011-04-27 |
| WO2008113756A3 (en) | 2008-12-18 |
| EP1972617A1 (en) | 2008-09-24 |
| US20100087505A1 (en) | 2010-04-08 |
| AU2008228260A1 (en) | 2008-09-25 |
| EP2121590A2 (en) | 2009-11-25 |
| MX2009009409A (es) | 2009-09-14 |
| JP2010521529A (ja) | 2010-06-24 |
| IL200951A0 (en) | 2010-05-17 |
| KR20090121329A (ko) | 2009-11-25 |
| AU2008228260B2 (en) | 2012-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130227 |
|
| FZDE | Discontinued |
Effective date: 20150316 |