CA2674543C - Quinolone carboxylic acids, derivatives thereof, and methods of making and using same - Google Patents

Quinolone carboxylic acids, derivatives thereof, and methods of making and using same Download PDF

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Publication number
CA2674543C
CA2674543C CA2674543A CA2674543A CA2674543C CA 2674543 C CA2674543 C CA 2674543C CA 2674543 A CA2674543 A CA 2674543A CA 2674543 A CA2674543 A CA 2674543A CA 2674543 C CA2674543 C CA 2674543C
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CA
Canada
Prior art keywords
groups
formula
substituted
group
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2674543A
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English (en)
French (fr)
Other versions
CA2674543A1 (en
Inventor
Arthur E. Harms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Lomb Inc
Original Assignee
Bausch and Lomb Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch and Lomb Inc filed Critical Bausch and Lomb Inc
Priority to CA2790690A priority Critical patent/CA2790690A1/en
Publication of CA2674543A1 publication Critical patent/CA2674543A1/en
Application granted granted Critical
Publication of CA2674543C publication Critical patent/CA2674543C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2674543A 2007-01-24 2008-01-11 Quinolone carboxylic acids, derivatives thereof, and methods of making and using same Expired - Fee Related CA2674543C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2790690A CA2790690A1 (en) 2007-01-24 2008-01-11 Quinoline carboxylic acids, derivatives thereof, and methods of making and using same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/626,397 US7632944B2 (en) 2007-01-24 2007-01-24 Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US11/626,397 2007-01-24
PCT/US2008/050865 WO2008091752A2 (en) 2007-01-24 2008-01-11 Quinolone carboxylic acids, derivatives thereof, processes for their preparation and their use as antibacterial agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2790690A Division CA2790690A1 (en) 2007-01-24 2008-01-11 Quinoline carboxylic acids, derivatives thereof, and methods of making and using same

Publications (2)

Publication Number Publication Date
CA2674543A1 CA2674543A1 (en) 2008-07-31
CA2674543C true CA2674543C (en) 2012-12-04

Family

ID=39410211

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2674543A Expired - Fee Related CA2674543C (en) 2007-01-24 2008-01-11 Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
CA2790690A Abandoned CA2790690A1 (en) 2007-01-24 2008-01-11 Quinoline carboxylic acids, derivatives thereof, and methods of making and using same

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2790690A Abandoned CA2790690A1 (en) 2007-01-24 2008-01-11 Quinoline carboxylic acids, derivatives thereof, and methods of making and using same

Country Status (10)

Country Link
US (1) US7632944B2 (https=)
EP (1) EP2114915A2 (https=)
JP (1) JP2010516775A (https=)
KR (1) KR20090118027A (https=)
CN (1) CN101595101A (https=)
AU (1) AU2008209416B2 (https=)
BR (1) BRPI0806581A2 (https=)
CA (2) CA2674543C (https=)
MX (1) MX2009007413A (https=)
WO (1) WO2008091752A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090054406A1 (en) * 2007-08-21 2009-02-26 Ward Keith W Compositions and Methods for Modulating Endophthalmitis Using Fluoroquinolones
US8415342B2 (en) * 2008-10-29 2013-04-09 Bausch & Lomb Incorporated Besifloxacin ophthalmic composition for the treatment or control of infection
AU2009314072C1 (en) 2008-11-15 2016-11-10 Melinta Subsidiary Corp. Antimicrobial compositions
US8481526B2 (en) * 2009-03-25 2013-07-09 Bausch & Lomb Incorporated Fluoroquinolone carboxylic acid molecular crystals
NL2004142C2 (nl) 2010-01-25 2011-07-26 Mci Mirror Controls Int Nl Bv Buitenspiegeleenheid, spiegeldrager, werkwijze voor montage van een buitenspiegeleenheid.
US10167271B2 (en) 2015-01-28 2019-01-01 Mankind Pharma Ltd Fluoroquinolone carboxylic acid compounds and use thereof for the preparation of besifloxacin hydrochloride
CN107880023B (zh) * 2017-11-10 2021-02-19 西南大学 氟喹诺酮类胺基衍生物及其用途
CN112159355B (zh) * 2020-09-25 2022-06-24 西南大学 对氨基水杨酸氟喹诺酮类衍生物及其中间体、制备方法和应用
CN112159354B (zh) * 2020-09-25 2022-07-05 西南大学 对氨基水杨酸的氟喹诺酮类衍生物及其中间体、制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1086735A (en) * 1977-11-03 1980-09-30 John C. Danilewicz Piperidino-quinazolines
EP0230946A3 (en) 1986-01-20 1988-09-07 Kyorin Pharmaceutical Co., Ltd. Process for the preparation of quinolonecarboxylic acid derivatives
JPS63132885A (ja) 1986-11-25 1988-06-04 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
JPS63196580A (ja) 1987-02-09 1988-08-15 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
JPS63196579A (ja) 1987-02-09 1988-08-15 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5430028A (en) 1992-05-26 1995-07-04 Ss Pharmaceutical Co., Ltd. 5-aminoquinolone carboxylic acid derivative and antibacterial agent containing the same as active ingredient
US5527910A (en) 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
TW301607B (https=) * 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
FR2706459B1 (fr) 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
SK33099A3 (en) * 1996-09-13 2000-05-16 Schering Corp Novel tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
US6685958B2 (en) * 2001-04-25 2004-02-03 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US6699492B2 (en) * 1999-03-31 2004-03-02 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
JP4612301B2 (ja) * 2003-12-26 2011-01-12 広栄化学工業株式会社 １−アルキル−４−アミノメチルピペリジンの製造法
DE102004035203A1 (de) * 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone

Also Published As

Publication number Publication date
CN101595101A (zh) 2009-12-02
AU2008209416B2 (en) 2013-05-09
US20080176834A1 (en) 2008-07-24
WO2008091752A2 (en) 2008-07-31
CA2674543A1 (en) 2008-07-31
BRPI0806581A2 (pt) 2014-05-06
WO2008091752A3 (en) 2008-10-16
EP2114915A2 (en) 2009-11-11
US7632944B2 (en) 2009-12-15
MX2009007413A (es) 2009-07-17
KR20090118027A (ko) 2009-11-17
JP2010516775A (ja) 2010-05-20
AU2008209416A1 (en) 2008-07-31
CA2790690A1 (en) 2008-07-31

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