CA2671769A1 - Treatment for dry eye - Google Patents
Treatment for dry eye Download PDFInfo
- Publication number
- CA2671769A1 CA2671769A1 CA002671769A CA2671769A CA2671769A1 CA 2671769 A1 CA2671769 A1 CA 2671769A1 CA 002671769 A CA002671769 A CA 002671769A CA 2671769 A CA2671769 A CA 2671769A CA 2671769 A1 CA2671769 A1 CA 2671769A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- progestagen
- pharmaceutically acceptable
- concentration
- acceptable carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 206010013774 Dry eye Diseases 0.000 title claims description 42
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
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| US11/634,347 US20080132475A1 (en) | 2006-12-05 | 2006-12-05 | Treatment for dry eye |
| US11/634,347 | 2006-12-05 | ||
| PCT/US2007/086515 WO2008070726A2 (en) | 2006-12-05 | 2007-12-05 | Treatment for dry eye |
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| CA2671769A1 true CA2671769A1 (en) | 2008-06-12 |
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| CA002671769A Abandoned CA2671769A1 (en) | 2006-12-05 | 2007-12-05 | Treatment for dry eye |
| CA002671698A Abandoned CA2671698A1 (en) | 2006-12-05 | 2007-12-05 | Treatment for dry eye using testosterone and progestagen |
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| CA002671698A Abandoned CA2671698A1 (en) | 2006-12-05 | 2007-12-05 | Treatment for dry eye using testosterone and progestagen |
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| EP (2) | EP2101785A4 (enExample) |
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| WO2009025763A2 (en) * | 2007-08-16 | 2009-02-26 | Schepens Eye Research Institute | Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues |
| US20100016264A1 (en) * | 2007-12-05 | 2010-01-21 | Connor Charles G | Treatment for dry eye using testosterone and progestagen |
| WO2010016042A1 (en) * | 2008-08-05 | 2010-02-11 | University College Cork, National University Of Ireland, Cork | Treatment of retinal degeneration |
| US9119772B2 (en) * | 2011-01-26 | 2015-09-01 | Allergan, Inc. | Androgen composition for treating an opthalmic condition |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| KR102097663B1 (ko) * | 2012-07-27 | 2020-04-06 | 글리아, 엘엘씨 | 눈 질병 및 질환을 위한 조성물 및 치료 |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| HUE034886T2 (hu) * | 2013-03-15 | 2018-03-28 | Glia Llc | Gyógyszerek cranialis adagolása |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10098894B2 (en) | 2014-07-29 | 2018-10-16 | Therapeuticsmd, Inc. | Transdermal cream |
| PT3848028T (pt) * | 2014-10-20 | 2024-09-20 | Oyster Point Pharma Inc | Métodos de tratamento de estados oculares |
| HK1246644A1 (zh) * | 2015-04-03 | 2018-09-14 | 参天制药株式会社 | 以诺龙或其酯、美替诺龙或其酯作为有效成分的乾眼症治疗剂 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| NZ751690A (en) | 2016-09-07 | 2022-02-25 | Glia Llc | Treatment of symptoms related to neurodegenerative disorders through pharmacological dermal activation of cranial nerves |
| CA3157934A1 (en) * | 2019-11-13 | 2021-05-20 | Kenneth I. Sawyer | Testosterone compositions |
| WO2023107796A1 (en) * | 2021-12-11 | 2023-06-15 | The Regents Of The University Of California | Ophthalmic formulations for macular degeneration |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2861920A (en) * | 1954-05-04 | 1958-11-25 | Upjohn Co | Therapeutic suspensions of steroids containing pvp and/or pva |
| JPS59184135A (ja) * | 1983-04-04 | 1984-10-19 | Teijin Ltd | グリセリンピログルタミン酸エステル類を含有する医薬品組成物 |
| US4617299A (en) * | 1983-12-19 | 1986-10-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
| DE3514724A1 (de) * | 1985-04-24 | 1986-10-30 | Albin F. Dr. 4200 Oberhausen Jereb | Salbe zur verbeugung und behandlung von augen- und hauterkrankungen |
| US4914088A (en) * | 1987-04-02 | 1990-04-03 | Thomas Glonek | Dry eye treatment solution and method |
| USRE34578E (en) * | 1990-05-07 | 1994-04-05 | Lubkin; Virginia | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| US5041434A (en) * | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| ZA912797B (en) * | 1990-05-29 | 1992-12-30 | Boston Ocular Res | Dry eye treatment process and solution |
| ATE185697T1 (de) * | 1992-04-21 | 1999-11-15 | Schepens Eye Res Inst | Androgentherapie am auge beim sjögrensyndrom |
| US5688765A (en) * | 1992-04-21 | 1997-11-18 | The Schepens Eye Research Institute, Inc. | Ocular therapy in Sjogren's syndrome using topically applied androgensor TGF-β |
| US6107289A (en) * | 1992-04-21 | 2000-08-22 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens or TGF-β |
| US5958912A (en) * | 1992-04-21 | 1999-09-28 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β |
| US5366739A (en) * | 1992-08-06 | 1994-11-22 | Deo Corporation | Method of ophthalmic drug delivery |
| EP0656779B1 (en) * | 1992-08-28 | 2000-04-12 | Pharmos Corporation | Submicron emulsions as ocular drug delivery vehicles |
| WO1997020578A1 (en) * | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
| CA2632790A1 (en) * | 1996-07-22 | 1998-01-29 | Renovo Limited | Use of sex steroid function modulators to treat wounds and fibrotic disorders |
| PL335410A1 (en) * | 1997-02-28 | 2000-04-25 | Minnesota Mining & Mfg | Medium for transcutaneous testosterone administration |
| US5869090A (en) * | 1998-01-20 | 1999-02-09 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| FR2774587B1 (fr) * | 1998-02-09 | 2000-03-10 | Oreal | Utilisation d'une microdispersion de cire dans une composition cosmetique ou dermatologique |
| US6348210B1 (en) * | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
| US6117446A (en) * | 1999-01-26 | 2000-09-12 | Place; Virgil A. | Drug dosage unit for buccal administration of steroidal active agents |
| CO5180583A1 (es) * | 1999-06-11 | 2002-07-30 | Watson Pharmaceuticals Inc | Administracion de esteroides androgenicos no orales a las mujeres |
| WO2001041806A1 (en) * | 1999-12-07 | 2001-06-14 | Rohto Pharmaceutical Co., Ltd. | Ophthalmic compositions |
| US6630175B1 (en) * | 2000-06-29 | 2003-10-07 | Johnson & Johnson Consumer Companies, Inc. | Method of reducing eye irritation |
| US6743448B2 (en) * | 2000-12-11 | 2004-06-01 | Abraham H. Kryger | Topical testosterone formulations and associated methods |
| US6659985B2 (en) * | 2002-01-30 | 2003-12-09 | Southern College Of Optometry | Method to use transdermal administration of androgens to the adnexa of the eye |
| AU2003290776A1 (en) * | 2002-11-15 | 2004-06-15 | Panaseca, Inc. | Methods and compositions for alleviating dry eyes |
| US20060111318A1 (en) * | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
| US7960350B2 (en) * | 2003-10-24 | 2011-06-14 | Ader Enterprises, Inc. | Composition and method for the treatment of eye disease |
| US20050202097A1 (en) * | 2004-03-12 | 2005-09-15 | Melbj Holdings, Llc, Florida | Lubricant for the ocular surface |
| US20050234018A1 (en) * | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| WO2006014484A2 (en) * | 2004-07-02 | 2006-02-09 | Surmodics, Inc. | Methods and devices for the treatment of ocular conditions |
| GB2438544A (en) * | 2005-02-09 | 2007-11-28 | Cooper Internat Corp | Liquid formulations for treatment of diseases or conditions |
| US20100016264A1 (en) * | 2007-12-05 | 2010-01-21 | Connor Charles G | Treatment for dry eye using testosterone and progestagen |
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2007
- 2007-12-05 EA EA200900662A patent/EA200900662A1/ru unknown
- 2007-12-05 EP EP07865242A patent/EP2101785A4/en not_active Withdrawn
- 2007-12-05 WO PCT/US2007/086517 patent/WO2008070728A2/en not_active Ceased
- 2007-12-05 CA CA002671769A patent/CA2671769A1/en not_active Abandoned
- 2007-12-05 JP JP2009540451A patent/JP2010511729A/ja active Pending
- 2007-12-05 KR KR1020097013349A patent/KR20090104814A/ko not_active Withdrawn
- 2007-12-05 MX MX2009005993A patent/MX2009005993A/es not_active Application Discontinuation
- 2007-12-05 CN CN200780049235A patent/CN101636164A/zh active Pending
- 2007-12-05 KR KR1020097013348A patent/KR20090104813A/ko not_active Withdrawn
- 2007-12-05 BR BRPI0719918-0A2A patent/BRPI0719918A2/pt not_active IP Right Cessation
- 2007-12-05 CA CA002671698A patent/CA2671698A1/en not_active Abandoned
- 2007-12-05 MX MX2009005994A patent/MX2009005994A/es not_active Application Discontinuation
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2020
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| CA2671698A1 (en) | 2008-06-12 |
| BRPI0719918A2 (pt) | 2014-03-04 |
| WO2008070726A3 (en) | 2008-08-21 |
| CN101636164A (zh) | 2010-01-27 |
| JP2010511730A (ja) | 2010-04-15 |
| US20140113889A1 (en) | 2014-04-24 |
| AU2009202711A1 (en) | 2009-07-23 |
| MX2009005993A (es) | 2009-12-14 |
| CN101636165A (zh) | 2010-01-27 |
| US20080132475A1 (en) | 2008-06-05 |
| WO2008070726A2 (en) | 2008-06-12 |
| IL199094A0 (en) | 2010-03-28 |
| KR20090104813A (ko) | 2009-10-06 |
| EP2101785A4 (en) | 2009-12-30 |
| KR20090104814A (ko) | 2009-10-06 |
| JP2010511729A (ja) | 2010-04-15 |
| BRPI0720172A2 (pt) | 2014-01-07 |
| MX2009005994A (es) | 2009-12-14 |
| EP2124958A4 (en) | 2009-12-30 |
| EP2101785A2 (en) | 2009-09-23 |
| WO2008070728A2 (en) | 2008-06-12 |
| WO2008070728A3 (en) | 2008-08-07 |
| EA200900663A1 (ru) | 2009-12-30 |
| US20210008079A1 (en) | 2021-01-14 |
| EP2124958A2 (en) | 2009-12-02 |
| EA200900662A1 (ru) | 2009-12-30 |
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