CA2670828A1 - Liquid chromatography detector and flow controller therefor - Google Patents
Liquid chromatography detector and flow controller therefor Download PDFInfo
- Publication number
- CA2670828A1 CA2670828A1 CA002670828A CA2670828A CA2670828A1 CA 2670828 A1 CA2670828 A1 CA 2670828A1 CA 002670828 A CA002670828 A CA 002670828A CA 2670828 A CA2670828 A CA 2670828A CA 2670828 A1 CA2670828 A1 CA 2670828A1
- Authority
- CA
- Canada
- Prior art keywords
- flow controller
- set forth
- cross
- liquid chromatography
- sectional area
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004811 liquid chromatography Methods 0.000 title claims abstract description 38
- 230000005465 channeling Effects 0.000 claims abstract description 6
- 238000001514 detection method Methods 0.000 claims description 43
- 239000006199 nebulizer Substances 0.000 claims description 27
- 238000004458 analytical method Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 8
- 239000012159 carrier gas Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 3
- 238000000105 evaporative light scattering detection Methods 0.000 description 25
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 7
- 229960000890 hydrocortisone Drugs 0.000 description 6
- 230000007423 decrease Effects 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000002912 waste gas Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8447—Nebulising, aerosol formation or ionisation
- G01N2030/847—Nebulising, aerosol formation or ionisation by pneumatic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8447—Nebulising, aerosol formation or ionisation
- G01N2030/8494—Desolvation chambers
Landscapes
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Flow Control (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Optical Measuring Cells (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86892406P | 2006-12-06 | 2006-12-06 | |
| US60/868,924 | 2006-12-06 | ||
| PCT/US2007/086640 WO2008070775A2 (en) | 2006-12-06 | 2007-12-06 | Liquid chromatography detector and flow controller therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2670828A1 true CA2670828A1 (en) | 2008-06-12 |
Family
ID=39493068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002670828A Abandoned CA2670828A1 (en) | 2006-12-06 | 2007-12-06 | Liquid chromatography detector and flow controller therefor |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100288026A1 (https=) |
| EP (1) | EP2087338A4 (https=) |
| JP (1) | JP2010512513A (https=) |
| KR (1) | KR20090106467A (https=) |
| CN (1) | CN101595377A (https=) |
| AU (1) | AU2007329302A1 (https=) |
| BR (1) | BRPI0719924A2 (https=) |
| CA (1) | CA2670828A1 (https=) |
| IL (1) | IL198964A0 (https=) |
| MX (1) | MX2009006058A (https=) |
| NO (1) | NO20092504L (https=) |
| RU (1) | RU2009125589A (https=) |
| WO (1) | WO2008070775A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2319334A1 (en) | 2009-10-27 | 2011-05-11 | Philip Morris Products S.A. | A smoking system having a liquid storage portion |
| CN102593695A (zh) * | 2012-01-18 | 2012-07-18 | 天津市天坤光电技术有限公司 | 一种提高激光晶体棒冷却效率的方法 |
| EP3695208B1 (en) * | 2019-01-02 | 2024-09-18 | Tosoh Corporation | Light scattering detectors and sample cells for the same |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3808550A (en) * | 1969-12-15 | 1974-04-30 | Bell Telephone Labor Inc | Apparatuses for trapping and accelerating neutral particles |
| US3894562A (en) * | 1973-12-20 | 1975-07-15 | Jr Charles D Moseley | Fluid flow controller |
| US4426213A (en) * | 1980-11-17 | 1984-01-17 | Engineering Resources, Inc. | Condensate removal device for steam lines and the like |
| JPS62118255A (ja) * | 1985-11-19 | 1987-05-29 | Toshimitsu Musha | 磁界を用いた免疫反応の検出法 |
| US4941618A (en) * | 1986-07-07 | 1990-07-17 | Leeman Labs Inc. | Nebulizer employing a fine mesh screen |
| US5061065A (en) * | 1989-10-20 | 1991-10-29 | Pacific Scientific Company | Particle contamination detection in fluids through the external section of a laser |
| US4958529A (en) * | 1989-11-22 | 1990-09-25 | Vestec Corporation | Interface for coupling liquid chromatography to solid or gas phase detectors |
| JP3087548B2 (ja) * | 1993-12-09 | 2000-09-11 | 株式会社日立製作所 | 液体クロマトグラフ結合型質量分析装置 |
| US5529244A (en) * | 1994-10-04 | 1996-06-25 | S. C. Johnson & Son, Inc. | Aspirator liquid blending device using multiple restrictors |
| US5837826A (en) * | 1995-02-27 | 1998-11-17 | Regents Of The University Of Minnesota | Protein adsorption by very dense porous zirconium oxide particles in expanded beds |
| US5872622A (en) * | 1996-08-12 | 1999-02-16 | Met One, Inc. | Condensation nucleus counter having vapor stabilization and working fluid recovery |
| JPH10162771A (ja) * | 1996-11-28 | 1998-06-19 | Jeol Ltd | 大気圧イオン源 |
| US6362880B1 (en) * | 1997-09-17 | 2002-03-26 | Alltech Associates, Inc. | Low temperature adaptor for evaporative light detection |
| DE19814650C2 (de) * | 1998-04-01 | 2002-02-28 | Aeroquip Vickers Internat Gmbh | Verfahren zur Herstellung einer Drosselstelle in einem Schlauch sowie Drosselstelle in einem Schlauch |
| US6024129A (en) * | 1998-07-16 | 2000-02-15 | Schima; Frank E. | Production efficient venturi insert |
| AU6045400A (en) * | 1999-02-25 | 2000-10-04 | Clemson University | Sampling and analysis of airborne particulate matter by glow discharge atomic emission and mass spectrometries |
| AU4856100A (en) * | 1999-05-17 | 2000-12-05 | Stephen T Flock | Electromagnetic energy driven separation methods |
| US6611780B2 (en) * | 1999-06-09 | 2003-08-26 | Koninklijke Philips Electronics N.V. | System for communicating operational data between an electric toothbrush and a separate control unit |
| US6229605B1 (en) * | 2000-03-10 | 2001-05-08 | Alltech Associates, Inc. | Evaporative light scattering device |
| US20020186263A1 (en) * | 2001-06-07 | 2002-12-12 | Nanostream, Inc. | Microfluidic fraction collectors |
| JP2003222612A (ja) * | 2002-01-30 | 2003-08-08 | Hitachi High-Technologies Corp | 大気圧イオン化質量分析装置および分析方法 |
| US6903818B2 (en) * | 2002-10-28 | 2005-06-07 | Particle Measuring Systems, Inc. | Low noise intracavity laser particle counter |
| GB0304253D0 (en) * | 2003-02-25 | 2003-03-26 | Polymer Lab Ltd | Apparatus |
| US6952013B2 (en) * | 2003-06-06 | 2005-10-04 | Esa Biosciences, Inc. | Electrochemistry with porous flow cell |
| US7114525B2 (en) * | 2003-08-29 | 2006-10-03 | Dana Corporation | Method and apparatus for reduction of fluid-borne noise in hydraulic systems |
| US7268881B2 (en) * | 2004-02-17 | 2007-09-11 | The Curators Of The University Of Missouri | Light scattering detector |
| JP5468206B2 (ja) * | 2005-01-18 | 2014-04-09 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 蒸発光散乱検出器 |
| US7760355B2 (en) * | 2005-07-27 | 2010-07-20 | The Curators Of The University Of Missouri | Focused droplet nebulizer for evaporative light scattering detector |
-
2007
- 2007-12-06 CN CNA2007800450177A patent/CN101595377A/zh active Pending
- 2007-12-06 BR BRPI0719924-4A2A patent/BRPI0719924A2/pt not_active Application Discontinuation
- 2007-12-06 WO PCT/US2007/086640 patent/WO2008070775A2/en not_active Ceased
- 2007-12-06 AU AU2007329302A patent/AU2007329302A1/en not_active Abandoned
- 2007-12-06 JP JP2009540474A patent/JP2010512513A/ja active Pending
- 2007-12-06 RU RU2009125589/28A patent/RU2009125589A/ru not_active Application Discontinuation
- 2007-12-06 CA CA002670828A patent/CA2670828A1/en not_active Abandoned
- 2007-12-06 KR KR1020097011687A patent/KR20090106467A/ko not_active Withdrawn
- 2007-12-06 MX MX2009006058A patent/MX2009006058A/es not_active Application Discontinuation
- 2007-12-06 US US12/517,951 patent/US20100288026A1/en not_active Abandoned
- 2007-12-06 EP EP07854985A patent/EP2087338A4/en not_active Withdrawn
-
2009
- 2009-05-26 IL IL198964A patent/IL198964A0/en unknown
- 2009-07-02 NO NO20092504A patent/NO20092504L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008070775A3 (en) | 2008-11-20 |
| IL198964A0 (en) | 2010-02-17 |
| RU2009125589A (ru) | 2011-01-20 |
| US20100288026A1 (en) | 2010-11-18 |
| JP2010512513A (ja) | 2010-04-22 |
| EP2087338A2 (en) | 2009-08-12 |
| EP2087338A4 (en) | 2010-04-07 |
| CN101595377A (zh) | 2009-12-02 |
| NO20092504L (no) | 2009-08-12 |
| AU2007329302A1 (en) | 2008-06-12 |
| MX2009006058A (es) | 2009-06-16 |
| BRPI0719924A2 (pt) | 2014-03-04 |
| KR20090106467A (ko) | 2009-10-09 |
| WO2008070775A2 (en) | 2008-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |