CA2669913C - Endoxifen methods and compositions - Google Patents
Endoxifen methods and compositions Download PDFInfo
- Publication number
- CA2669913C CA2669913C CA2669913A CA2669913A CA2669913C CA 2669913 C CA2669913 C CA 2669913C CA 2669913 A CA2669913 A CA 2669913A CA 2669913 A CA2669913 A CA 2669913A CA 2669913 C CA2669913 C CA 2669913C
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- CA
- Canada
- Prior art keywords
- endoxifen
- acid
- use according
- composition
- cholesterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 47
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- 206010006187 Breast cancer Diseases 0.000 claims abstract description 43
- 208000026310 Breast neoplasm Diseases 0.000 claims abstract description 42
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
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- Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86042006P | 2006-11-21 | 2006-11-21 | |
| US60/860,420 | 2006-11-21 | ||
| US86078806P | 2006-11-22 | 2006-11-22 | |
| US60/860,788 | 2006-11-22 | ||
| PCT/US2007/085443 WO2008070463A2 (en) | 2006-11-21 | 2007-11-21 | Endoxifen methods and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2669913A1 CA2669913A1 (en) | 2008-06-12 |
| CA2669913C true CA2669913C (en) | 2012-09-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2669913A Active CA2669913C (en) | 2006-11-21 | 2007-11-21 | Endoxifen methods and compositions |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9333190B2 (OSRAM) |
| EP (1) | EP2101731B1 (OSRAM) |
| JP (1) | JP2010510327A (OSRAM) |
| CA (1) | CA2669913C (OSRAM) |
| DK (1) | DK2101731T3 (OSRAM) |
| ES (1) | ES2665917T3 (OSRAM) |
| HU (1) | HUE037109T2 (OSRAM) |
| IN (1) | IN2014MN00139A (OSRAM) |
| PL (1) | PL2101731T3 (OSRAM) |
| PT (1) | PT2101731T (OSRAM) |
| WO (1) | WO2008070463A2 (OSRAM) |
Families Citing this family (17)
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| PT2101731T (pt) | 2006-11-21 | 2018-04-18 | Jina Pharmaceuticals Inc | Endoxifeno para utilização no tratamento de cancro |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| DK2373305T3 (en) * | 2008-12-11 | 2017-05-15 | Besins Healthcare Lu Sarl | TRANSDERMAL PHARMACEUTICAL COMPOSITIONS INCLUDING A SERM |
| EP3656393B1 (en) | 2011-04-28 | 2022-08-24 | Oncopeptides AB | Lyophilized preparation of cytotoxic dipeptides |
| EP2668945A1 (de) | 2012-06-01 | 2013-12-04 | Bayer Technology Services GmbH | Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen |
| US10285946B2 (en) * | 2012-10-26 | 2019-05-14 | Oncopeptides Ab | Lyophilized preparations of melphalan flufenamide |
| JP2018520182A (ja) * | 2015-07-14 | 2018-07-26 | アトッサ ジェネティックス インク． | 乳房障害を処置するための経乳頭方法及び組成物 |
| DE102015222031A1 (de) | 2015-11-10 | 2017-05-11 | Robert Bosch Gesellschaft Für Medizinische Forschung Mbh | Synthese von (Z)-Endoxifenhydrochlorid |
| US20170304232A1 (en) * | 2016-04-20 | 2017-10-26 | Northwestern University | Endoxifen For Local Transdermal Therapy To The Breast |
| JP7766316B2 (ja) | 2017-09-11 | 2025-11-10 | アトッサ・セラピューティクス・インコーポレイテッド | エンドキシフェンを製造および使用する方法 |
| MX2020002683A (es) * | 2017-09-11 | 2020-09-25 | Atossa Therapeutics Inc | Composiciones topicas y metodos de tratamiento. |
| AU2020300624A1 (en) | 2019-07-03 | 2022-02-03 | Atossa Therapeutics, Inc. | Sustained release compositions of endoxifen |
| WO2021205402A1 (en) | 2020-04-10 | 2021-10-14 | Jina Pharmaceuticals, Inc. | Endoxifen for the treatment of bipolar i disorder |
| CA3185993A1 (en) | 2020-04-10 | 2021-10-14 | Jina Pharmaceuticals, Inc. | Endoxifen for the treatment of bipolar i disorder |
| TW202302073A (zh) * | 2021-03-18 | 2023-01-16 | 予宇生技股份有限公司 | 包含帶電脂質的脂質製劑的組合物及製備方法 |
| TW202340135A (zh) | 2022-01-12 | 2023-10-16 | 美商阿托薩醫療公司 | （ｚ）—因多昔芬之組合物及其富集方法 |
| EP4514327A1 (en) * | 2022-04-26 | 2025-03-05 | Atossa Therapeutics, Inc. | High dose endoxifen formulations and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2817157A1 (de) * | 1978-04-17 | 1979-10-25 | Schering Ag | Verwendung von antioestrogenen und antigonadotrop wirkenden antiandrogenen zur prophylaxe und therapie der prostatahyperplasie |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| EP1138319A3 (en) * | 1994-08-04 | 2003-03-19 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| AU736301B2 (en) * | 1996-05-01 | 2001-07-26 | Imarx Therapeutics, Inc. | Methods for delivering compounds into a cell |
| US6090407A (en) * | 1997-09-23 | 2000-07-18 | Research Development Foundation | Small particle liposome aerosols for delivery of anti-cancer drugs |
| US7968532B2 (en) | 2003-12-15 | 2011-06-28 | Besins Healthcare Luxembourg | Treatment of gynecomastia with 4-hydroxy tamoxifen |
| JP5917789B2 (ja) | 2006-10-10 | 2016-05-18 | ジャイナ ファーマシューティカルズ，インコーポレーテッド | 脂質ベースの医薬化合物の製造のための水性系、その組成物、方法、および使用 |
| WO2008048194A1 (en) | 2006-10-20 | 2008-04-24 | Yesilogluj Aysegul Yildiz | Use of the protein kinase c inhibitor tamoxifen for the treatment of bipolar disorder |
| CA2669355C (en) | 2006-11-06 | 2012-10-30 | Jina Pharmaceuticals, Inc. | Guggulphospholipid methods and compositions |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| PT2101731T (pt) | 2006-11-21 | 2018-04-18 | Jina Pharmaceuticals Inc | Endoxifeno para utilização no tratamento de cancro |
| JP5720881B2 (ja) | 2011-01-31 | 2015-05-20 | 東芝ライテック株式会社 | Ｌｅｄランプ点灯装置および照明装置 |
-
2007
- 2007-11-21 PT PT78715638T patent/PT2101731T/pt unknown
- 2007-11-21 HU HUE07871563A patent/HUE037109T2/hu unknown
- 2007-11-21 WO PCT/US2007/085443 patent/WO2008070463A2/en not_active Ceased
- 2007-11-21 PL PL07871563T patent/PL2101731T3/pl unknown
- 2007-11-21 JP JP2009538518A patent/JP2010510327A/ja active Pending
- 2007-11-21 EP EP07871563.8A patent/EP2101731B1/en not_active Revoked
- 2007-11-21 IN IN139MUN2014 patent/IN2014MN00139A/en unknown
- 2007-11-21 DK DK07871563.8T patent/DK2101731T3/en active
- 2007-11-21 ES ES07871563.8T patent/ES2665917T3/es active Active
- 2007-11-21 US US12/515,261 patent/US9333190B2/en active Active
- 2007-11-21 CA CA2669913A patent/CA2669913C/en active Active
-
2016
- 2016-04-27 US US15/139,687 patent/US10376479B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010510327A (ja) | 2010-04-02 |
| US9333190B2 (en) | 2016-05-10 |
| EP2101731A2 (en) | 2009-09-23 |
| IN2014MN00139A (OSRAM) | 2015-06-19 |
| PT2101731T (pt) | 2018-04-18 |
| PL2101731T3 (pl) | 2018-07-31 |
| EP2101731B1 (en) | 2018-01-31 |
| CA2669913A1 (en) | 2008-06-12 |
| DK2101731T3 (en) | 2018-04-16 |
| WO2008070463A2 (en) | 2008-06-12 |
| HUE037109T2 (hu) | 2018-08-28 |
| US10376479B2 (en) | 2019-08-13 |
| US20100112041A1 (en) | 2010-05-06 |
| EP2101731A4 (en) | 2011-04-20 |
| US20160346230A1 (en) | 2016-12-01 |
| ES2665917T3 (es) | 2018-04-30 |
| WO2008070463A9 (en) | 2008-09-18 |
| WO2008070463A3 (en) | 2008-11-06 |
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