CA2668743A1 - Liposome preparation by single-pass process - Google Patents

Liposome preparation by single-pass process Download PDF

Info

Publication number
CA2668743A1
CA2668743A1 CA002668743A CA2668743A CA2668743A1 CA 2668743 A1 CA2668743 A1 CA 2668743A1 CA 002668743 A CA002668743 A CA 002668743A CA 2668743 A CA2668743 A CA 2668743A CA 2668743 A1 CA2668743 A1 CA 2668743A1
Authority
CA
Canada
Prior art keywords
liposomes
suspension
solution
nozzle
porous device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002668743A
Other languages
English (en)
French (fr)
Inventor
Michael Wiggenhorn
Gerhard Winter
Heinrich Haas
Klaus Drexler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medigene AG
Ludwig Maximilians Universitaet Muenchen LMU
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2668743A1 publication Critical patent/CA2668743A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CA002668743A 2006-11-07 2007-11-02 Liposome preparation by single-pass process Abandoned CA2668743A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06023155.2 2006-11-07
EP06023155A EP1920765A1 (en) 2006-11-07 2006-11-07 Liposome preparation by single-pass process
PCT/EP2007/009531 WO2008055628A1 (en) 2006-11-07 2007-11-02 Liposome preparation by single-pass process

Publications (1)

Publication Number Publication Date
CA2668743A1 true CA2668743A1 (en) 2008-05-15

Family

ID=37898375

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002668743A Abandoned CA2668743A1 (en) 2006-11-07 2007-11-02 Liposome preparation by single-pass process

Country Status (6)

Country Link
US (1) US20100316696A1 (enExample)
EP (2) EP1920765A1 (enExample)
JP (1) JP2010508368A (enExample)
AU (1) AU2007316931A1 (enExample)
CA (1) CA2668743A1 (enExample)
WO (1) WO2008055628A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
WO2010031877A1 (en) * 2008-09-22 2010-03-25 Nanologica Ab Hybrid silica -polycarbonate porous membranes and porous polycarbonate replicas obtained thereof
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JP6043278B2 (ja) 2010-04-09 2016-12-14 パシラ ファーマシューティカルズ インコーポレーテッド 多小胞リポソームを作製するための方法、大直径合成膜小胞を調製するための方法、および蒸発装置
EP2394640A1 (en) * 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
EP2402075A1 (de) * 2010-06-28 2012-01-04 Bühler AG Verfahren und Vorrichtung zur Herstellung von Vesikeln
US8708159B2 (en) * 2011-02-16 2014-04-29 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
JP6184945B2 (ja) 2011-06-08 2017-08-23 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド ｍＲＮＡ送達のための脂質ナノ粒子組成物および方法
GB201119032D0 (en) 2011-11-03 2011-12-14 Isis Innovation Multisomes: encapsulated droplet networks
CN103906503B (zh) 2011-11-04 2016-12-14 日东电工株式会社 用于无菌制备脂质-核酸颗粒的单次使用系统
WO2013117671A1 (fr) * 2012-02-07 2013-08-15 Centre National De La Recherche Scientifique (C.N.R.S) Préparation de nanoparticules par évaporation flash
GB201219201D0 (en) 2012-10-25 2012-12-12 Isis Innovation Hydrogel network
GB201219196D0 (en) 2012-10-25 2012-12-12 Isis Innovation Droplet assembly method
KR102284661B1 (ko) * 2012-12-07 2021-08-02 옥스포드 유니버시티 이노베이션 리미티드 3d 프린팅에 의한 비말 어셈블리
US9592198B2 (en) * 2013-10-28 2017-03-14 University Of Maryland, College Park Microfluidic liposome synthesis, purification and active drug loading
CN105581983B (zh) * 2014-10-21 2019-11-05 中国科学院上海药物研究所 高频超声雾化微粒制备系统
JP6316182B2 (ja) 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
EP3302781B1 (en) * 2015-05-29 2020-09-16 Givaudan S.A. Spray drying
FR3066115B1 (fr) * 2017-05-10 2019-06-28 Universite de Bordeaux Comprimes de vecteurs d'acides nucleiques
AU2017438994A1 (en) * 2017-11-09 2020-05-28 Immunovaccine Technologies Inc. Pharmaceutical compositions, methods for preparation comprising sizing of lipid vesicle particles, and uses thereof
WO2020117145A2 (en) * 2018-10-02 2020-06-11 Iğdir Üni̇versi̇tesi̇ Reducing atmosphere spraying dryer system
CN115607982A (zh) * 2022-09-28 2023-01-17 山西钢科碳材料有限公司 二甲基亚砜精馏残液回收系统及其回收方法
CN117018649B (zh) * 2023-10-09 2023-12-15 山西旺龙药业集团有限公司 一种药用猴头菌丝体喷雾干燥塔及其使用方法
CN118376804B (zh) * 2024-06-25 2024-09-13 华昕生物医药(山东)集团有限公司 脂质体在线提取检测装置

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1264668C (en) * 1984-06-20 1990-01-23 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
JPS6475418A (en) * 1987-09-14 1989-03-22 Terumo Corp Production of liposome
JP2599492B2 (ja) * 1990-08-21 1997-04-09 第一製薬株式会社 リポソーム製剤の製造法
AU665853B2 (en) * 1992-06-29 1996-01-18 Dade International Inc. Sample tube carrier
DE4328331A1 (de) * 1993-08-18 1995-02-23 Andreas Dr Sachse Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen
US5554382A (en) * 1993-05-28 1996-09-10 Aphios Corporation Methods and apparatus for making liposomes
US7094423B1 (en) * 1999-07-15 2006-08-22 Inex Pharmaceuticals Corp. Methods for preparation of lipid-encapsulated therapeutic agents
KR20010010393A (ko) * 1999-07-20 2001-02-05 김윤 소수성 고분자와 친수성 고분자의 생분해성 블록 공중합체 및이를 포함하는 약물 전달체 조성물
DE10214983A1 (de) * 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
AU2003268087A1 (en) * 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
EP1915987A1 (en) * 2006-10-27 2008-04-30 MediGene AG Spray-freeze-drying process for the preparation of pellets comprising percolation drying

Also Published As

Publication number Publication date
WO2008055628A1 (en) 2008-05-15
EP1920765A1 (en) 2008-05-14
US20100316696A1 (en) 2010-12-16
EP2094239A1 (en) 2009-09-02
AU2007316931A1 (en) 2008-05-15
JP2010508368A (ja) 2010-03-18

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20141104