CA2666058A1 - Aqueous liquid preparation comprising gatifloxacin - Google Patents
Aqueous liquid preparation comprising gatifloxacin Download PDFInfo
- Publication number
- CA2666058A1 CA2666058A1 CA002666058A CA2666058A CA2666058A1 CA 2666058 A1 CA2666058 A1 CA 2666058A1 CA 002666058 A CA002666058 A CA 002666058A CA 2666058 A CA2666058 A CA 2666058A CA 2666058 A1 CA2666058 A1 CA 2666058A1
- Authority
- CA
- Canada
- Prior art keywords
- gatifloxacin
- liquid preparation
- aqueous liquid
- acid
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229960003923 gatifloxacin Drugs 0.000 title claims abstract description 53
- XUBOMFCQGDBHNK-JTQLQIEISA-N (S)-gatifloxacin Chemical compound FC1=CC(C(C(C(O)=O)=CN2C3CC3)=O)=C2C(OC)=C1N1CCN[C@@H](C)C1 XUBOMFCQGDBHNK-JTQLQIEISA-N 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 50
- 239000007788 liquid Substances 0.000 title claims abstract description 42
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 20
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- 150000001875 compounds Chemical class 0.000 claims description 2
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- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical class C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 description 4
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- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 description 3
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- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006-279009 | 2006-10-12 | ||
| JP2006279009 | 2006-10-12 | ||
| PCT/JP2007/069847 WO2008044734A1 (fr) | 2006-10-12 | 2007-10-11 | Préparation liquide aqueuse comprenant de la gatifloxacine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2666058A1 true CA2666058A1 (en) | 2008-04-17 |
Family
ID=39282924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002666058A Abandoned CA2666058A1 (en) | 2006-10-12 | 2007-10-11 | Aqueous liquid preparation comprising gatifloxacin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100041623A1 (zh) |
| EP (1) | EP2078527A4 (zh) |
| JP (1) | JPWO2008044734A1 (zh) |
| KR (1) | KR20090064572A (zh) |
| CN (1) | CN101573118B (zh) |
| BR (1) | BRPI0719514A2 (zh) |
| CA (1) | CA2666058A1 (zh) |
| MX (1) | MX2009003878A (zh) |
| WO (1) | WO2008044734A1 (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009123098A1 (ja) * | 2008-03-31 | 2009-10-08 | 杏林製薬株式会社 | ガチフロキサシン含有水性液剤、その製造方法、および、該水性液剤の低温保存および凍結融解時の沈殿生成を抑制する方法 |
| TWI495469B (zh) | 2008-06-09 | 2015-08-11 | Alcon Res Ltd | 含有氟喹諾酮抗生素藥物之經改良藥學組成物 |
| TW201038295A (en) | 2009-04-17 | 2010-11-01 | Alcon Res Ltd | Aqueous ophthalmic compositions containing anionic therapeutic agents |
| UA92423C2 (ru) * | 2009-07-24 | 2010-10-25 | Анатолій Альбертович Кузьмін | Антибактериальная композиция |
| CN102078284B (zh) * | 2009-11-27 | 2013-06-12 | 沈阳兴齐眼药股份有限公司 | 一种含加替沙星的眼用凝胶剂及其制备方法 |
| IL212725A (en) * | 2011-05-05 | 2016-06-30 | Resdevco Res And Dev Co | Glycerol Preparation for Non-surgical Conjunctivochalysis |
| TW201309306A (zh) * | 2011-06-23 | 2013-03-01 | 參天製藥股份有限公司 | 含有玻尿酸或其鹽及丙二醇之點眼液 |
| GR1008168B (el) * | 2013-03-14 | 2014-04-08 | "Φαρματεν Α.Β.Ε.Ε.", | Παρεντερικο σκευασμα αντιβακτηριακου παραγοντα φθοριοκινολονης και μεθοδος για την παρασκευη αυτου |
| US20170014339A1 (en) * | 2015-07-17 | 2017-01-19 | i.com medical GmbH | Tear Substitute, Fluid for Being Used as a Tear Substitute, and Method for Producing a Tear Substitute |
| CN105168119A (zh) * | 2015-10-28 | 2015-12-23 | 周胜光 | 一种治疗鼻炎的复方滴鼻用凝胶制剂 |
| CN112569211A (zh) * | 2019-09-27 | 2021-03-30 | 盈科瑞（天津）创新医药研究有限公司 | 一种吸入用加替沙星溶液及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH089597B2 (ja) | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
| JPH0696533B2 (ja) | 1987-01-14 | 1994-11-30 | 北陸製薬株式会社 | キノロンカルボン酸の水性組成物 |
| AU761040B2 (en) * | 1998-08-21 | 2003-05-29 | Kyorin Pharmaceutical Co. Ltd. | Aqueous liquid preparations |
| JP2002037746A (ja) | 2000-07-24 | 2002-02-06 | Fuji Yakuhin:Kk | キノロンカルボン酸系抗菌剤を含有する液剤 |
| CN1488404A (zh) * | 2003-06-19 | 2004-04-14 | 刘继东 | 眼用制剂中玻璃酸钠的复合应用 |
| US20050222769A1 (en) * | 2003-06-26 | 2005-10-06 | Jefferey Simon | Modular sensor system |
| WO2005000307A1 (en) * | 2003-06-26 | 2005-01-06 | Santen Pharmaceutical Co., Ltd. | Ophthalmic composition containing quinolones and method of use |
| US20050009836A1 (en) * | 2003-06-26 | 2005-01-13 | Laskar Paul A. | Ophthalmic composition containing quinolones and method of use |
| CN100427091C (zh) * | 2004-04-20 | 2008-10-22 | 沈阳药科大学 | 以hpmc为基质的加替沙星眼用凝胶剂及其制备方法 |
| CN1839840A (zh) * | 2006-01-12 | 2006-10-04 | 张宏业 | 一种新的加替沙星滴眼液及其制备方法 |
-
2007
- 2007-10-11 BR BRPI0719514-1A2A patent/BRPI0719514A2/pt not_active IP Right Cessation
- 2007-10-11 US US12/311,728 patent/US20100041623A1/en not_active Abandoned
- 2007-10-11 WO PCT/JP2007/069847 patent/WO2008044734A1/ja active Application Filing
- 2007-10-11 JP JP2008538754A patent/JPWO2008044734A1/ja not_active Withdrawn
- 2007-10-11 MX MX2009003878A patent/MX2009003878A/es not_active Application Discontinuation
- 2007-10-11 KR KR1020097007402A patent/KR20090064572A/ko not_active Application Discontinuation
- 2007-10-11 EP EP07829585A patent/EP2078527A4/en not_active Withdrawn
- 2007-10-11 CA CA002666058A patent/CA2666058A1/en not_active Abandoned
- 2007-10-11 CN CN2007800376785A patent/CN101573118B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2078527A1 (en) | 2009-07-15 |
| MX2009003878A (es) | 2009-09-15 |
| JPWO2008044734A1 (ja) | 2010-02-18 |
| US20100041623A1 (en) | 2010-02-18 |
| CN101573118B (zh) | 2011-09-07 |
| CN101573118A (zh) | 2009-11-04 |
| KR20090064572A (ko) | 2009-06-19 |
| BRPI0719514A2 (pt) | 2014-10-07 |
| EP2078527A4 (en) | 2011-12-21 |
| WO2008044734A1 (fr) | 2008-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20131011 |