CA2663965C - Pyrazolopyrimidine derivative and use thereof as an anticancer agent - Google Patents

Pyrazolopyrimidine derivative and use thereof as an anticancer agent Download PDF

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Publication number
CA2663965C
CA2663965C CA2663965A CA2663965A CA2663965C CA 2663965 C CA2663965 C CA 2663965C CA 2663965 A CA2663965 A CA 2663965A CA 2663965 A CA2663965 A CA 2663965A CA 2663965 C CA2663965 C CA 2663965C
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CA
Canada
Prior art keywords
group
substituent
compound
carbon atoms
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2663965A
Other languages
English (en)
French (fr)
Other versions
CA2663965A1 (en
Inventor
Satoru Ohsuki
Atsushi Tengeiji
Masahiro Ikeda
Yoshihiro Shibata
Chikahiro Nagata
Takashi Shimada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CA2663965A1 publication Critical patent/CA2663965A1/en
Application granted granted Critical
Publication of CA2663965C publication Critical patent/CA2663965C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2663965A 2006-09-19 2007-09-14 Pyrazolopyrimidine derivative and use thereof as an anticancer agent Expired - Fee Related CA2663965C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006-253465 2006-09-19
JP2006253465 2006-09-19
PCT/JP2007/067933 WO2008035629A1 (fr) 2006-09-19 2007-09-14 Dérivé de pyrazolopyrimidine

Publications (2)

Publication Number Publication Date
CA2663965A1 CA2663965A1 (en) 2008-03-27
CA2663965C true CA2663965C (en) 2012-06-12

Family

ID=39200455

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2663965A Expired - Fee Related CA2663965C (en) 2006-09-19 2007-09-14 Pyrazolopyrimidine derivative and use thereof as an anticancer agent

Country Status (26)

Country Link
US (1) US8158638B2 (de)
EP (1) EP2065388B1 (de)
JP (1) JP5252636B2 (de)
KR (2) KR20140127367A (de)
CN (1) CN101541811B (de)
AT (1) ATE523513T1 (de)
AU (1) AU2007298286B2 (de)
BR (1) BRPI0717176A2 (de)
CA (1) CA2663965C (de)
CO (1) CO6210702A2 (de)
CY (1) CY1112191T1 (de)
DK (1) DK2065388T3 (de)
ES (1) ES2373160T3 (de)
HK (1) HK1127476A1 (de)
IL (1) IL197513A (de)
MX (1) MX2009002998A (de)
MY (1) MY145041A (de)
NO (1) NO20091495L (de)
NZ (1) NZ575564A (de)
PL (1) PL2065388T3 (de)
PT (1) PT2065388E (de)
RU (1) RU2420530C2 (de)
SI (1) SI2065388T1 (de)
TW (1) TWI388563B (de)
WO (1) WO2008035629A1 (de)
ZA (1) ZA200901921B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110131190A (ko) * 2009-02-25 2011-12-06 다이이찌 산쿄 가부시키가이샤 3 고리성 피라졸로피리미딘 유도체
TW201102390A (en) * 2009-03-31 2011-01-16 Arqule Inc Substituted pyrazolo-pyrimidine compounds
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CN103052642A (zh) * 2010-08-23 2013-04-17 第一三共株式会社 三环吡唑并嘧啶衍生物的晶体
TW201213334A (en) * 2010-08-23 2012-04-01 Daiichi Sankyo Co Ltd Crystal forms of free form of tricyclic pyrazolopyrimidine derivative
CN105764502A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群及其类似物及衍生物的治疗益处的组合方法
CN114380738A (zh) * 2021-09-28 2022-04-22 都创(重庆)医药科技有限公司 一种3-溴-4-氯-2-甲基吡啶的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615934D0 (en) 1996-07-30 1996-09-11 Netlon Ltd Integral tube
EP0973788A1 (de) 1997-04-02 2000-01-26 Amersham Pharmacia Biotech UK Limited Trizyklische basenanaloge
JP2001526639A (ja) 1997-04-02 2001-12-18 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド 三環式塩基類似体
KR100772297B1 (ko) 2002-11-22 2007-11-02 니뽄 다바코 산교 가부시키가이샤 융합 비시클릭 질소-함유 헤테로사이클
MXPA06002198A (es) 2003-08-27 2007-08-14 Biota Scient Management Nucleosidos o nucleotidos triciclicos novedosos como agentes terapeuticos.
US7148228B2 (en) 2003-09-18 2006-12-12 Conforma Therapeutics Corporation Pyrazolopyrimidines and related analogs as HSP90-inhibitors
WO2006015263A2 (en) 2004-07-29 2006-02-09 Threshold Pharmaceuticals, Inc. Lonidamine analogs

Also Published As

Publication number Publication date
TWI388563B (zh) 2013-03-11
KR20090066274A (ko) 2009-06-23
EP2065388A4 (de) 2009-11-18
ZA200901921B (en) 2009-12-30
EP2065388A1 (de) 2009-06-03
WO2008035629A1 (fr) 2008-03-27
KR101485199B1 (ko) 2015-01-22
PT2065388E (pt) 2011-11-10
DK2065388T3 (da) 2012-01-09
IL197513A (en) 2014-01-30
IL197513A0 (en) 2009-12-24
AU2007298286A1 (en) 2008-03-27
CN101541811B (zh) 2014-07-09
MX2009002998A (es) 2009-04-02
JP5252636B2 (ja) 2013-07-31
CA2663965A1 (en) 2008-03-27
US20100113410A1 (en) 2010-05-06
RU2009114731A (ru) 2010-10-27
PL2065388T3 (pl) 2012-02-29
NZ575564A (en) 2011-02-25
HK1127476A1 (en) 2009-09-25
CY1112191T1 (el) 2015-12-09
SI2065388T1 (sl) 2012-03-30
EP2065388B1 (de) 2011-09-07
ATE523513T1 (de) 2011-09-15
CO6210702A2 (es) 2010-10-20
MY145041A (en) 2011-12-15
TW200823223A (en) 2008-06-01
US8158638B2 (en) 2012-04-17
CN101541811A (zh) 2009-09-23
ES2373160T3 (es) 2012-02-01
AU2007298286B2 (en) 2011-02-03
RU2420530C2 (ru) 2011-06-10
KR20140127367A (ko) 2014-11-03
BRPI0717176A2 (pt) 2013-10-15
JPWO2008035629A1 (ja) 2010-01-28
NO20091495L (no) 2009-06-18

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20170914