CA2661952A1 - Procedes non invasifs pour l'utilisation d'informations spectrales dans la determination de concentrations d'analytes - Google Patents

Procedes non invasifs pour l'utilisation d'informations spectrales dans la determination de concentrations d'analytes Download PDF

Info

Publication number
CA2661952A1
CA2661952A1 CA002661952A CA2661952A CA2661952A1 CA 2661952 A1 CA2661952 A1 CA 2661952A1 CA 002661952 A CA002661952 A CA 002661952A CA 2661952 A CA2661952 A CA 2661952A CA 2661952 A1 CA2661952 A1 CA 2661952A1
Authority
CA
Canada
Prior art keywords
skin tissue
raman
fluorescence
intensity light
collected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002661952A
Other languages
English (en)
Inventor
Mihailo V. Rebec
Michael P. Houlne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2661952A1 publication Critical patent/CA2661952A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé non invasif pour la détermination de la concentration d'un analyte à l'aide d'informations spectrales Raman ou de fluorescence. Une bande de lumière de haute intensité est appliquée sur un côté du tissu de la peau. La lumière de haute intensité pénètre dans le tissu cutané et génère un signal Raman ou de fluorescence. Une matière de génération de Raman ou une matière de génération de fluorescence est placée à un endroit aussi proche que possible, de l'autre côté du tissu cutané. La matière de génération de Raman ou de fluorescence est située en général à l'opposé de l'entrée de la lumière de haute intensité appliquée. Le signal Raman ou de fluorescence est recueilli et la concentration d'analyte est déterminée à l'aide du signal Raman collecté.
CA002661952A 2006-08-22 2007-08-17 Procedes non invasifs pour l'utilisation d'informations spectrales dans la determination de concentrations d'analytes Abandoned CA2661952A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83929906P 2006-08-22 2006-08-22
US60/839,299 2006-08-22
PCT/US2007/018310 WO2008024288A2 (fr) 2006-08-22 2007-08-17 Procédés non invasifs pour l'utilisation d'informations spectrales dans la détérmination de concentrations d'analytes

Publications (1)

Publication Number Publication Date
CA2661952A1 true CA2661952A1 (fr) 2008-02-28

Family

ID=39107321

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002661952A Abandoned CA2661952A1 (fr) 2006-08-22 2007-08-17 Procedes non invasifs pour l'utilisation d'informations spectrales dans la determination de concentrations d'analytes

Country Status (5)

Country Link
EP (1) EP2056716A2 (fr)
JP (1) JP2010501252A (fr)
CA (1) CA2661952A1 (fr)
TW (1) TW200819732A (fr)
WO (1) WO2008024288A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
US9662047B2 (en) * 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
KR101207695B1 (ko) * 2010-08-11 2012-12-03 서울대학교산학협력단 형광 및 라만 신호 표적에 대한 형광 및 라만 신호 동시검출방법 및 이를 이용한 표적 동시검출용 의학영상장치
CN102821688A (zh) * 2011-04-12 2012-12-12 松下电器产业株式会社 对生物体中所含有的生物体成分的浓度进行测定的方法
US8509868B2 (en) 2011-04-12 2013-08-13 Panasonic Corporation Method for measuring a concentration of a biogenic substance contained in a living body
JP6212303B2 (ja) * 2013-06-28 2017-10-11 景博 内田 糖尿病マーカーの測定方法
CN103529013A (zh) * 2013-10-18 2014-01-22 福建师范大学 一种基于dcdr光谱技术的精浆果糖快速检测的方法
KR101651659B1 (ko) * 2015-02-12 2016-08-30 한국광기술원 광 간섭 단층촬영을 이용한 색소 병변의 정량화 시스템 및 방법
CN114295522B (zh) * 2021-12-28 2024-03-29 华东理工大学 基于振动光谱成像的渗透深度及空间浓度分布的分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6070093A (en) * 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US6975891B2 (en) * 2001-12-21 2005-12-13 Nir Diagnostics Inc. Raman spectroscopic system with integrating cavity
WO2006127766A1 (fr) * 2005-05-25 2006-11-30 Bayer Healthcare Llc Procedes d'utilisation de l'information de spectre raman dans la determination des concentrations d'une substance a analyser

Also Published As

Publication number Publication date
TW200819732A (en) 2008-05-01
EP2056716A2 (fr) 2009-05-13
JP2010501252A (ja) 2010-01-21
WO2008024288A2 (fr) 2008-02-28
WO2008024288A3 (fr) 2008-11-13

Similar Documents

Publication Publication Date Title
US8452357B2 (en) Non-invasive methods of using spectral information in determining analyte concentrations
CA2661952A1 (fr) Procedes non invasifs pour l'utilisation d'informations spectrales dans la determination de concentrations d'analytes
US8452365B2 (en) Methods of using Raman spectral information in determining analyte concentrations
US5481113A (en) Apparatus and method for measuring concentrations of components with light scattering
US7952692B2 (en) Method and apparatus for determination of analyte concentration
CA1247397A (fr) Methode et appareil de spectrophotometrie pour le dosage non invasif du glucose dans les tissus corporels
US6646738B2 (en) Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
US7809418B2 (en) Optical device components
US11147482B2 (en) Method and system for non-invasive blood glucose measurement using signal change of the non-glucose components induced by the presence of glucose
WO2006119314A2 (fr) Procede et dispositif permettant de determiner la saturation en oxygene de l'hemoglobine, de determiner l'hematocrite d'un echantillon de sang et/ou de detecter la degenerescence maculaire
KR100464324B1 (ko) 목적물의 성분농도 측정방법 및 장치
JP2010501252A5 (fr)
US20060211926A1 (en) Non-invasive Raman measurement apparatus with broadband spectral correction
JP4706028B2 (ja) 血糖値測定装置及び方法
KR100634498B1 (ko) 체내성분 측정장치 및 방법
EP2038639A1 (fr) Spectroscopie d'eclairage spectral special
WO2007060583A2 (fr) Procede et appareil pour determiner des concentrations d'analytes dans un fluide trouble
KR20020085625A (ko) 목적물의 성분 농도 측정 장치 및 방법
Dutta et al. Fluorescence photobleaching of urine for improved signal to noise ratio of the Raman signal–An exploratory study
JP2004313554A (ja) 血糖値の非侵襲測定装置
JP4483052B2 (ja) 非侵襲血糖計
US9392943B2 (en) System for glycated protein detection
WO2010002278A1 (fr) Système de détection de protéine glyquée
JP2003215033A (ja) 生体成分定量装置およびその方法
KR20230126508A (ko) 분광 원리 기반 비침습적 농도 측정 방법 및 이를 수행하는 시스템

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130405

FZDE Discontinued

Effective date: 20130405