WO2008024288A3 - Procédés non invasifs pour l'utilisation d'informations spectrales dans la détérmination de concentrations d'analytes - Google Patents

Procédés non invasifs pour l'utilisation d'informations spectrales dans la détérmination de concentrations d'analytes Download PDF

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Publication number
WO2008024288A3
WO2008024288A3 PCT/US2007/018310 US2007018310W WO2008024288A3 WO 2008024288 A3 WO2008024288 A3 WO 2008024288A3 US 2007018310 W US2007018310 W US 2007018310W WO 2008024288 A3 WO2008024288 A3 WO 2008024288A3
Authority
WO
WIPO (PCT)
Prior art keywords
raman
fluorescence
spectral information
analyte concentrations
invasive methods
Prior art date
Application number
PCT/US2007/018310
Other languages
English (en)
Other versions
WO2008024288A2 (fr
Inventor
Mihailo V Rebec
Michael P Houlne
Original Assignee
Bayer Healthcare Llc
Mihailo V Rebec
Michael P Houlne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc, Mihailo V Rebec, Michael P Houlne filed Critical Bayer Healthcare Llc
Priority to EP07837020A priority Critical patent/EP2056716A2/fr
Priority to CA002661952A priority patent/CA2661952A1/fr
Priority to JP2009525575A priority patent/JP2010501252A/ja
Publication of WO2008024288A2 publication Critical patent/WO2008024288A2/fr
Publication of WO2008024288A3 publication Critical patent/WO2008024288A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé non invasif pour la détermination de la concentration d'un analyte à l'aide d'informations spectrales Raman ou de fluorescence. Une bande de lumière de haute intensité est appliquée sur un côté du tissu de la peau. La lumière de haute intensité pénètre dans le tissu cutané et génère un signal Raman ou de fluorescence. Une matière de génération de Raman ou une matière de génération de fluorescence est placée à un endroit aussi proche que possible, de l'autre côté du tissu cutané. La matière de génération de Raman ou de fluorescence est située en général à l'opposé de l'entrée de la lumière de haute intensité appliquée. Le signal Raman ou de fluorescence est recueilli et la concentration d'analyte est déterminée à l'aide du signal Raman collecté.
PCT/US2007/018310 2006-08-22 2007-08-17 Procédés non invasifs pour l'utilisation d'informations spectrales dans la détérmination de concentrations d'analytes WO2008024288A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07837020A EP2056716A2 (fr) 2006-08-22 2007-08-17 Procédés non invasifs pour l'utilisation d'informations spectrales dans la détérmination de concentrations d'analytes
CA002661952A CA2661952A1 (fr) 2006-08-22 2007-08-17 Procedes non invasifs pour l'utilisation d'informations spectrales dans la determination de concentrations d'analytes
JP2009525575A JP2010501252A (ja) 2006-08-22 2007-08-17 スペクトル情報を使用して、分析対象物の濃度を決定する、非侵襲的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83929906P 2006-08-22 2006-08-22
US60/839,299 2006-08-22

Publications (2)

Publication Number Publication Date
WO2008024288A2 WO2008024288A2 (fr) 2008-02-28
WO2008024288A3 true WO2008024288A3 (fr) 2008-11-13

Family

ID=39107321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018310 WO2008024288A2 (fr) 2006-08-22 2007-08-17 Procédés non invasifs pour l'utilisation d'informations spectrales dans la détérmination de concentrations d'analytes

Country Status (5)

Country Link
EP (1) EP2056716A2 (fr)
JP (1) JP2010501252A (fr)
CA (1) CA2661952A1 (fr)
TW (1) TW200819732A (fr)
WO (1) WO2008024288A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
US9662047B2 (en) * 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
KR101207695B1 (ko) * 2010-08-11 2012-12-03 서울대학교산학협력단 형광 및 라만 신호 표적에 대한 형광 및 라만 신호 동시검출방법 및 이를 이용한 표적 동시검출용 의학영상장치
JP5076035B1 (ja) * 2011-04-12 2012-11-21 パナソニック株式会社 生体に含有される生体成分の濃度を測定する方法
US8509868B2 (en) 2011-04-12 2013-08-13 Panasonic Corporation Method for measuring a concentration of a biogenic substance contained in a living body
JP6212303B2 (ja) * 2013-06-28 2017-10-11 景博 内田 糖尿病マーカーの測定方法
CN103529013A (zh) * 2013-10-18 2014-01-22 福建师范大学 一种基于dcdr光谱技术的精浆果糖快速检测的方法
KR101651659B1 (ko) * 2015-02-12 2016-08-30 한국광기술원 광 간섭 단층촬영을 이용한 색소 병변의 정량화 시스템 및 방법
CN114295522B (zh) * 2021-12-28 2024-03-29 华东理工大学 基于振动光谱成像的渗透深度及空间浓度分布的分析方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6070093A (en) * 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US20030120137A1 (en) * 2001-12-21 2003-06-26 Romuald Pawluczyk Raman spectroscopic system with integrating cavity
WO2006127766A1 (fr) * 2005-05-25 2006-11-30 Bayer Healthcare Llc Procedes d'utilisation de l'information de spectre raman dans la determination des concentrations d'une substance a analyser

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6070093A (en) * 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US20030120137A1 (en) * 2001-12-21 2003-06-26 Romuald Pawluczyk Raman spectroscopic system with integrating cavity
WO2006127766A1 (fr) * 2005-05-25 2006-11-30 Bayer Healthcare Llc Procedes d'utilisation de l'information de spectre raman dans la determination des concentrations d'une substance a analyser

Also Published As

Publication number Publication date
TW200819732A (en) 2008-05-01
CA2661952A1 (fr) 2008-02-28
JP2010501252A (ja) 2010-01-21
EP2056716A2 (fr) 2009-05-13
WO2008024288A2 (fr) 2008-02-28

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