CA2655372A1 - Il-17 and il-23 antagonists and methods of using the same - Google Patents
Il-17 and il-23 antagonists and methods of using the same Download PDFInfo
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- CA2655372A1 CA2655372A1 CA002655372A CA2655372A CA2655372A1 CA 2655372 A1 CA2655372 A1 CA 2655372A1 CA 002655372 A CA002655372 A CA 002655372A CA 2655372 A CA2655372 A CA 2655372A CA 2655372 A1 CA2655372 A1 CA 2655372A1
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80460206P | 2006-06-13 | 2006-06-13 | |
| US60/804,602 | 2006-06-13 | ||
| US82466506P | 2006-09-06 | 2006-09-06 | |
| US60/824,665 | 2006-09-06 | ||
| US82827706P | 2006-10-05 | 2006-10-05 | |
| US60/828,277 | 2006-10-05 | ||
| US89141007P | 2007-02-23 | 2007-02-23 | |
| US60/891,410 | 2007-02-23 | ||
| PCT/US2007/071152 WO2007147019A2 (en) | 2006-06-13 | 2007-06-13 | Il-17 and il-23 antagonists and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2655372A1 true CA2655372A1 (en) | 2007-12-21 |
Family
ID=38832829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002655372A Abandoned CA2655372A1 (en) | 2006-06-13 | 2007-06-13 | Il-17 and il-23 antagonists and methods of using the same |
Country Status (7)
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Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ573837A (en) | 2003-07-08 | 2010-07-30 | Genentech Inc | IL-17 A/F heterologous polypeptides and therapeutic uses thereof |
| CA2589746A1 (en) * | 2004-12-08 | 2006-06-15 | Cedars-Sinai Medical Center | Methods for diagnosis and treatment of crohn's disease |
| US7790862B2 (en) | 2006-06-13 | 2010-09-07 | Zymogenetics, Inc. | IL-17 and IL-23 antagonists and methods of using the same |
| US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
| JP5118699B2 (ja) | 2006-08-11 | 2013-01-16 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｉｌ−１７ａに対する抗体 |
| US8414897B1 (en) | 2006-10-02 | 2013-04-09 | The Uab Research Foundation | Pathway for Th-17 cell development and methods utilizing same |
| TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Ｉｌ-２３拮抗劑於治療感染之用途 |
| US20100021917A1 (en) * | 2007-02-14 | 2010-01-28 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
| EP2064242A1 (en) * | 2007-02-23 | 2009-06-03 | Schering Corporation | Engineered anti-il-23p19 antibodies |
| AR065420A1 (es) | 2007-02-23 | 2009-06-03 | Schering Corp | Anticuerpos anti-il-23 p19 de ingenieria |
| US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| WO2010039931A2 (en) * | 2008-10-01 | 2010-04-08 | Cedars-Sinai Medical Center | Methods of using il17rd and il23-il17 pathway genes to diagnose crohn's disease |
| CN101668531B (zh) | 2007-02-28 | 2014-05-07 | 默沙东公司 | 用于治疗免疫病症的联合治疗 |
| WO2008106579A2 (en) * | 2007-02-28 | 2008-09-04 | Cedars-Sinai Medical Center | The role of il-12, il-23 and il-17 receptors in inflammatory bowel disease |
| US20100015156A1 (en) * | 2007-03-06 | 2010-01-21 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
| WO2008116150A2 (en) | 2007-03-21 | 2008-09-25 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease |
| US20100184050A1 (en) * | 2007-04-26 | 2010-07-22 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
| CA2683145C (en) * | 2007-04-27 | 2018-06-12 | Katherine E. Lewis | Antagonists to il-17a, il-17f, and il-23p19 and methods of use |
| US20100144903A1 (en) * | 2007-05-04 | 2010-06-10 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
| US9305137B1 (en) | 2007-05-18 | 2016-04-05 | Cedars-Sinai Medical Center | Methods of identifying the genetic basis of a disease by a combinatorial genomics approach, biological pathway approach, and sequential approach |
| EP3246045B1 (en) * | 2007-07-26 | 2025-09-03 | Osaka University | Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient |
| US20100203009A1 (en) * | 2007-10-02 | 2010-08-12 | The Uab Research Foundation | Pathway for Th-17 Cell Development and Methods Utilizing Same |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| EP2604279A1 (en) | 2008-03-27 | 2013-06-19 | ZymoGenetics, Inc. | Compositions and methods for inhibiting PDGFRBETA and VEGF-A |
| CN102083858B (zh) | 2008-05-05 | 2015-01-14 | 诺维莫尼公司 | 抗il-17a/il-17f交叉反应性抗体及其使用方法 |
| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| WO2010019565A2 (en) * | 2008-08-12 | 2010-02-18 | Medlmmune, Llc | Anti-ephrin b2 antibodies and their use in treatment of disease |
| EP2331078B1 (en) | 2008-08-27 | 2012-09-19 | Merck Sharp & Dohme Corp. | Lyophilized formulations of engineered anti-il-23p19 antibodies |
| US8790642B2 (en) * | 2008-08-29 | 2014-07-29 | Genentech, Inc. | Cross-reactive and bispecific anti-IL-17A/F antibodies |
| US20110189685A1 (en) * | 2008-10-22 | 2011-08-04 | Cedars-Sinai Medical Center | Methods of using jak3 genetic variants to diagnose and predict crohn's disease |
| AU2009314111A1 (en) * | 2008-11-12 | 2010-05-20 | Merck Sharp & Dohme Corp. | BetaGI-IgG intron for enhanced anti-IGF1 R expression |
| US8211434B2 (en) | 2008-11-26 | 2012-07-03 | Allergan, Inc. | KLK-13 antibody inhibitor for treating dry eye |
| US20110223169A1 (en) * | 2008-11-26 | 2011-09-15 | Stern Michael E | Il-17 antibody inhibitor for treating dry eye |
| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| US20110250644A1 (en) | 2008-12-19 | 2011-10-13 | Schering Corporation | Feed supplement for mammalian cell culture and methods of use |
| US9580752B2 (en) | 2008-12-24 | 2017-02-28 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy |
| CN102458437B (zh) | 2009-05-05 | 2015-06-10 | 诺维莫尼公司 | 抗il-17f抗体及其使用方法 |
| SG176963A1 (en) | 2009-06-22 | 2012-02-28 | Amgen Inc | Refolding proteins using a chemically controlled redox state |
| WO2010151688A2 (en) | 2009-06-25 | 2010-12-29 | Amgen Inc. | Capture purification processes for proteins expressed in a non-mammalian system |
| WO2011017294A1 (en) | 2009-08-07 | 2011-02-10 | Schering Corporation | Human anti-rankl antibodies |
| JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| PE20121363A1 (es) * | 2009-10-30 | 2012-10-15 | Janssen Biotech Inc | Antagonistas de il-17a |
| GB201013975D0 (en) | 2010-08-20 | 2010-10-06 | Imp Innovations Ltd | Method of treating desease |
| US9045536B2 (en) | 2009-12-23 | 2015-06-02 | Merck Sharp & Dohme Corp. | Cell line 3M |
| SI3345615T1 (sl) | 2010-03-01 | 2020-03-31 | Bayer Healthcare Llc | Optimizirana monoklonska protitelesa proti zaviralcu poti tkivnega faktorja (TFPI) |
| WO2011119948A1 (en) * | 2010-03-26 | 2011-09-29 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| US20110311527A1 (en) | 2010-06-16 | 2011-12-22 | Allergan, Inc. | IL23p19 ANTIBODY INHIBITOR FOR TREATING OCULAR AND OTHER CONDITIONS |
| PL2635601T3 (pl) | 2010-11-04 | 2017-02-28 | Boehringer Ingelheim International Gmbh | Przeciwciała anty-il-23 |
| EP2668210B1 (en) | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| JP6058645B2 (ja) | 2011-06-10 | 2017-01-11 | メディミューン，エルエルシー | 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）Ｐｓｌ結合分子およびその使用 |
| USRE49026E1 (en) | 2011-06-14 | 2022-04-12 | Medical Diagnostic Laboratories, Llc | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| US8946150B2 (en) | 2011-06-14 | 2015-02-03 | Medical Diagnostic Laboratories, LLC. | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| EP2583979B1 (en) * | 2011-10-19 | 2015-12-16 | Effimune | Methods to prepare antibodies directed against p19 subunit of human IL-23 |
| PT2776065T (pt) | 2011-11-07 | 2020-09-25 | Medimmune Ltd | Terapias de combinação que usam moléculas de ligação de psl e pcrv anti-pseudomonas |
| EP2809660B1 (en) | 2012-02-02 | 2016-01-20 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
| PL3326649T3 (pl) | 2012-05-03 | 2022-04-25 | Boehringer Ingelheim International Gmbh | Przeciwciała anty-il-23p19 |
| ES2711554T3 (es) | 2012-05-22 | 2019-05-06 | Bristol Myers Squibb Co | Anticuerpos biespecíficos contra IL-17A/F IL-23 y sus usos |
| JP2015518043A (ja) * | 2012-05-31 | 2015-06-25 | エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ | タンパク質製剤中の凝集物含量を低減する混合型多官能金属アフィニティー表面 |
| ES2729603T3 (es) | 2012-06-27 | 2019-11-05 | Merck Sharp & Dohme | Anticuerpos IL-23 antihumanos cristalinos |
| NZ731881A (en) | 2012-07-25 | 2022-07-29 | Celldex Therapeutics Inc | Anti-kit antibodies and uses thereof |
| CN105007939B (zh) * | 2012-10-05 | 2018-10-19 | 卡德门企业有限公司 | 人抗vegfr-2/kdr抗体 |
| CN105101996A (zh) * | 2012-10-05 | 2015-11-25 | 卡德门企业有限公司 | 眼部病症的治疗 |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| SG10201805015TA (en) | 2013-03-15 | 2018-07-30 | Amgen Inc | Methods for treating crohn's disease using an anti-il23 antibody |
| US9822157B2 (en) | 2013-03-15 | 2017-11-21 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses thereof |
| EP3689369A1 (en) | 2013-03-15 | 2020-08-05 | Amgen, Inc | Methods for treating psoriasis using an anti-il-23 antibody |
| CA2891557A1 (en) | 2013-03-26 | 2014-05-22 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| AU2014241162A1 (en) | 2013-03-27 | 2015-10-22 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways |
| US10316083B2 (en) | 2013-07-19 | 2019-06-11 | Cedars-Sinai Medical Center | Signature of TL1A (TNFSF15) signaling pathway |
| RU2577228C2 (ru) * | 2014-03-14 | 2016-03-10 | Закрытое Акционерное Общество "Биокад" | Анти-il-17-антитела, способ их получения и способ применения |
| EP3960754A3 (en) | 2014-05-16 | 2022-07-06 | Protagonist Therapeutics, Inc. | Alpha4beta7 integrin thioether peptide antagonists |
| AU2015261968B2 (en) | 2014-05-22 | 2018-11-22 | Pieris Pharmaceuticals Gmbh | Novel specific-binding polypeptides and uses thereof |
| US10239943B2 (en) | 2014-05-23 | 2019-03-26 | Celldex Therapeutics, Inc. | Treatment of eosinophil or mast cell related disorders |
| TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| PE20220371A1 (es) * | 2014-07-14 | 2022-03-16 | Gennova Biopharmaceuticals Ltd | PROCEDIMIENTO NOVEDOSO PARA LA PURIFICACION DE rHU-GCSF |
| WO2016011208A1 (en) | 2014-07-17 | 2016-01-21 | Protagonist Therapeutics, Inc. | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| EP3708679A1 (en) | 2014-07-24 | 2020-09-16 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| EA039598B9 (ru) | 2014-09-03 | 2022-03-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединение, нацеленное на ил-23а и фно-альфа, и его применение |
| AU2015328002A1 (en) | 2014-10-01 | 2017-04-27 | Protagonist Therapeutics, Inc. | Novel alpha4beta7 peptide monomer and dimer antagonists |
| EP3201217A4 (en) | 2014-10-01 | 2018-07-18 | Protagonist Therapeutics Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| AR102417A1 (es) * | 2014-11-05 | 2017-03-01 | Lilly Co Eli | Anticuerpos biespecíficos anti-tnf- / anti-il-23 |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| KR20240158362A (ko) | 2015-02-04 | 2024-11-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 염증성 질환의 치료 방법 |
| EP3262411B1 (en) | 2015-02-25 | 2022-04-06 | Vanderbilt University | Antibody-mediated neutralization of marburg virus |
| US20180036404A1 (en) | 2015-03-02 | 2018-02-08 | 180 Therapeutics Lp | Method of treating a localized fibrotic disorder using a tnf receptor 2 antagonist |
| CA2977534A1 (en) * | 2015-04-14 | 2016-10-20 | Boehringer Ingelheim International Gmbh | Methods of treating diseases |
| EP3297673A4 (en) | 2015-05-22 | 2019-05-08 | Memorial Sloan-Kettering Cancer Center | FOR A PRAME-PEPTIDE SPECIFIC T-CELL RECEPTOR-SIMILAR ANTIBODIES |
| MA41010B1 (fr) * | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| WO2017049035A1 (en) | 2015-09-17 | 2017-03-23 | Amgen Inc. | Prediction of clinical response to il23-antagonists using il23 pathway biomarkers |
| US10894834B2 (en) * | 2015-11-27 | 2021-01-19 | Csl Limited | CD131 binding proteins |
| BR112018012626A2 (pt) | 2015-12-22 | 2018-12-04 | Amgen Inc | ccl20 como um preditor de resposta clínica a antagonistas de il23 |
| CA3009834A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| WO2017161342A1 (en) | 2016-03-17 | 2017-09-21 | Cedars-Sinai Medical Center | Methods of diagnosing inflammatory bowel disease through rnaset2 |
| CA3017926C (en) | 2016-03-23 | 2023-10-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing .alpha.4.beta.7 peptide antagonists |
| WO2017205820A1 (en) * | 2016-05-27 | 2017-11-30 | The Board Of Trustees Of The Leland Stanford Junior University | Affinity matured broad spectrum antibodies to hepatitis c virus |
| US9611297B1 (en) * | 2016-08-26 | 2017-04-04 | Thrasos Therapeutics Inc. | Compositions and methods for the treatment of cast nephropathy and related conditions |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| SG11201909955XA (en) | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| WO2019157268A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CN112203685A (zh) * | 2018-03-29 | 2021-01-08 | 瑞美德生物医药科技有限公司 | 使用结合白细胞介素-17a(il-17a)的抗体的自身免疫紊乱和炎性紊乱的治疗 |
| KR20210032441A (ko) | 2018-07-13 | 2021-03-24 | 아스트라제네카 콜라보레이션 벤처스, 엘엘씨 | 브라지쿠맙을 이용한 궤양성 대장염의 치료 |
| WO2020097139A1 (en) | 2018-11-07 | 2020-05-14 | Merck Sharp & Dohme Corp. | Co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| CA3146390A1 (en) | 2019-07-10 | 2021-01-14 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| AU2020409124A1 (en) | 2019-12-20 | 2022-06-30 | Novarock Biotherapeutics, Ltd. | Anti-interleukin-23 p19 antibodies and methods of use thereof |
| LT4090670T (lt) | 2020-01-15 | 2025-08-11 | Janssen Biotech, Inc. | Interleukino-23 receptorių peptidiniai inhibitoriai ir jų naudojimas uždegiminėms ligoms gydyti |
| JP2023511551A (ja) | 2020-01-15 | 2023-03-20 | ヤンセン バイオテツク，インコーポレーテツド | インターロイキン２３受容体のペプチド阻害剤及び炎症性疾患を治療するためのその使用 |
| WO2022087293A1 (en) * | 2020-10-22 | 2022-04-28 | Twist Bioscience Corporation | Methods and systems for detecting coronavirus |
| EP4247403A4 (en) | 2020-11-20 | 2024-12-11 | JANSSEN Pharmaceutica NV | COMPOSITIONS OF PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR |
| EP4370146A4 (en) | 2021-07-14 | 2025-05-21 | Janssen Biotech, Inc. | Lipidated peptide inhibitors of the interleukin-23 receptor |
| WO2023122211A2 (en) * | 2021-12-21 | 2023-06-29 | Duke University | Coronavirus antibodies and uses thereof |
| CN120826416A (zh) * | 2022-12-02 | 2025-10-21 | 杰科生物医药公司 | 抗间皮素双特异性抗体及其使用方法 |
| WO2025071335A1 (ko) * | 2023-09-27 | 2025-04-03 | 삼성바이오에피스 주식회사 | 항-il-17 항체의 안정한 액상 제형 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA986596B (en) | 1997-07-25 | 1999-02-08 | Schering Corp | Mammalian cytokine related reagents |
| US6060284A (en) * | 1997-07-25 | 2000-05-09 | Schering Corporation | DNA encoding interleukin-B30 |
| AU2661199A (en) | 1998-02-06 | 1999-08-23 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
| DE69942607D1 (de) * | 1998-04-14 | 2010-09-02 | Chugai Pharmaceutical Co Ltd | Neues cytokinartiges protein |
| US7090847B1 (en) * | 1999-09-09 | 2006-08-15 | Schering Corporation | Mammalian cytokines; related reagents and methods |
| CN100529076C (zh) | 1999-09-09 | 2009-08-19 | 先灵公司 | 哺乳动物细胞因子、相关试剂和方法 |
| US7422743B2 (en) * | 2000-05-10 | 2008-09-09 | Schering Corporation | Mammalian receptor protein DCRS5;methods of treatment |
| EP1494712A4 (en) | 2002-03-26 | 2006-06-14 | Centocor Inc | MULTIPLE SCLEROSIS RELATED PROTEINS, COMPOSITIONS, PROCESSES AND APPLICATIONS DERIVED FROM IMMUNOGLOBULIN |
| WO2003091700A2 (en) | 2002-03-26 | 2003-11-06 | Centocor, Inc. | Epitope mapping using nuclear magnetic resonance |
| JP4902961B2 (ja) | 2002-12-23 | 2012-03-21 | シェーリング コーポレイション | 哺乳動物サイトカインの用途；関連試薬 |
| EP1589998B1 (en) | 2002-12-31 | 2011-04-27 | Schering Corporation | IL-27 and IL-2 for use in the treatment of cancer |
| US20040219150A1 (en) * | 2003-02-06 | 2004-11-04 | Cua Daniel J. | Uses of mammalian cytokine; related reagents |
| NZ541898A (en) | 2003-03-10 | 2008-07-31 | Schering Corp | Uses of IL-23 antagonists for the manufacture of a medicament for the treatment of tumors |
| NZ573837A (en) | 2003-07-08 | 2010-07-30 | Genentech Inc | IL-17 A/F heterologous polypeptides and therapeutic uses thereof |
| US7485297B2 (en) * | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
| US20050043517A1 (en) * | 2003-08-20 | 2005-02-24 | Jill Giles-Komar | Method for generating antibodies |
| AU2005215527B2 (en) | 2004-02-17 | 2011-04-07 | Merck Sharp & Dohme Corp. | Methods of modulating IL-23 activity; related reagents |
| BRPI0510617A (pt) * | 2004-05-03 | 2007-10-30 | Schering Corp | uso de expressão de il-17 para prever inflamação de pele; processos de tratamento |
| US20050287593A1 (en) * | 2004-05-03 | 2005-12-29 | Schering Corporation | Use of cytokine expression to predict skin inflammation; methods of treatment |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| AR051444A1 (es) * | 2004-09-24 | 2007-01-17 | Centocor Inc | Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos |
| GB0425569D0 (en) | 2004-11-19 | 2004-12-22 | Celltech R&D Ltd | Biological products |
| TWI363091B (en) * | 2004-12-20 | 2012-05-01 | Schering Corp | Uses of mammalian cytokine; related reagents |
| KR100631924B1 (ko) * | 2005-01-24 | 2006-10-04 | 삼성전자주식회사 | 반도체 설비의 잔류부산물 포집장치 |
| HUE042561T2 (hu) * | 2005-06-30 | 2019-07-29 | Janssen Biotech Inc | Anti-IL-23-ellenanyagok, készítmények, eljárások és alkalmazások |
| DK1937721T3 (da) | 2005-08-25 | 2010-10-18 | Lilly Co Eli | Anti-IL-23 antistoffer |
| US20070048306A1 (en) * | 2005-08-30 | 2007-03-01 | Giles-Komar Jill M | Method for generating anti-variable region monoclonal antibodies |
| ES2619845T3 (es) * | 2005-08-31 | 2017-06-27 | Merck Sharp & Dohme Corp. | Anticuerpos anti-IL-23 diseñados por ingeniería genética |
| NZ566424A (en) * | 2005-09-01 | 2011-10-28 | Schering Corp | Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease |
| KR20080074136A (ko) | 2005-10-28 | 2008-08-12 | 센토코 인코포레이티드 | 항체의 생성에 있어서의 ｂ 세포 팽창제의 사용 |
| AU2006330410A1 (en) | 2005-12-28 | 2007-07-05 | Centocor, Inc. | Markers and methods for assessing and treating psoriasis and related disorders |
| ES2807928T3 (es) | 2005-12-29 | 2021-02-24 | Janssen Biotech Inc | Anticuerpos anti-IL-23 humanos, composiciones, procedimientos y usos |
| US7910703B2 (en) * | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
| AU2007226627B2 (en) | 2006-03-10 | 2012-09-20 | Zymogenetics, Inc. | Antibodies that bind both IL-17A and IL-17F and methods of using the same |
| US7790862B2 (en) | 2006-06-13 | 2010-09-07 | Zymogenetics, Inc. | IL-17 and IL-23 antagonists and methods of using the same |
| RU2008141368A (ru) | 2006-03-21 | 2010-04-27 | Шеринг Корпорейшн (US) | Новые гетероциклические соединения замещенного пиридина с антагонистической активностью схсr3 |
| MX2009006871A (es) | 2006-12-22 | 2009-07-07 | Schering Corp | Compuestos heterociclicos con actividad antagonista de cxcr3. |
| EP2064242A1 (en) | 2007-02-23 | 2009-06-03 | Schering Corporation | Engineered anti-il-23p19 antibodies |
| AR065420A1 (es) | 2007-02-23 | 2009-06-03 | Schering Corp | Anticuerpos anti-il-23 p19 de ingenieria |
| CN101668531B (zh) | 2007-02-28 | 2014-05-07 | 默沙东公司 | 用于治疗免疫病症的联合治疗 |
| WO2009082624A2 (en) | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
-
2007
- 2007-06-13 US US11/762,738 patent/US7790862B2/en active Active
- 2007-06-13 JP JP2009515638A patent/JP2009540018A/ja active Pending
- 2007-06-13 AU AU2007260787A patent/AU2007260787A1/en not_active Abandoned
- 2007-06-13 EP EP07798524A patent/EP2044118A2/en not_active Withdrawn
- 2007-06-13 CA CA002655372A patent/CA2655372A1/en not_active Abandoned
- 2007-06-13 WO PCT/US2007/071152 patent/WO2007147019A2/en not_active Ceased
-
2008
- 2008-11-19 IL IL195382A patent/IL195382A0/en unknown
-
2010
- 2010-08-27 US US12/870,199 patent/US8227579B2/en active Active
-
2012
- 2012-06-21 US US13/528,918 patent/US20120295310A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120295310A1 (en) | 2012-11-22 |
| US20110059087A1 (en) | 2011-03-10 |
| US8227579B2 (en) | 2012-07-24 |
| JP2009540018A (ja) | 2009-11-19 |
| US7790862B2 (en) | 2010-09-07 |
| US20080095775A1 (en) | 2008-04-24 |
| IL195382A0 (en) | 2011-08-01 |
| WO2007147019A2 (en) | 2007-12-21 |
| EP2044118A2 (en) | 2009-04-08 |
| AU2007260787A1 (en) | 2007-12-21 |
| WO2007147019A3 (en) | 2008-08-07 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20130613 |