CA2654877A1 - Stable elsamitrucin salts suitable for pharmaceutical formulations - Google Patents
Stable elsamitrucin salts suitable for pharmaceutical formulations Download PDFInfo
- Publication number
- CA2654877A1 CA2654877A1 CA002654877A CA2654877A CA2654877A1 CA 2654877 A1 CA2654877 A1 CA 2654877A1 CA 002654877 A CA002654877 A CA 002654877A CA 2654877 A CA2654877 A CA 2654877A CA 2654877 A1 CA2654877 A1 CA 2654877A1
- Authority
- CA
- Canada
- Prior art keywords
- elsamitrucin
- salt
- stable solid
- tosylate
- parenteral formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- MGQRRMONVLMKJL-KWJIQSIXSA-N elsamitrucin Chemical class O1[C@H](C)[C@H](O)[C@H](OC)[C@@H](N)[C@H]1O[C@@H]1[C@](O)(C)[C@@H](O)[C@@H](C)O[C@H]1OC1=CC=CC2=C(O)C(C(O3)=O)=C4C5=C3C=CC(C)=C5C(=O)OC4=C12 MGQRRMONVLMKJL-KWJIQSIXSA-N 0.000 title claims abstract description 162
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- 229950002339 elsamitrucin Drugs 0.000 claims description 95
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
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- -1 elsamitrucin tosylate salt Chemical class 0.000 claims description 11
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- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 229940127073 nucleoside analogue Drugs 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 230000000174 oncolytic effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000007044 single strand scission Effects 0.000 description 1
- 230000005783 single-strand break Effects 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000723 toxicological property Toxicity 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 241001446247 uncultured actinomycete Species 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2007/069693 WO2008143677A1 (en) | 2007-05-24 | 2007-05-24 | Stable solid elsamitrucin salts suitable for pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2654877A1 true CA2654877A1 (en) | 2008-11-27 |
Family
ID=39639324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002654877A Abandoned CA2654877A1 (en) | 2007-05-24 | 2007-05-24 | Stable elsamitrucin salts suitable for pharmaceutical formulations |
Country Status (6)
| Country | Link |
|---|---|
| KR (1) | KR20100014080A (es) |
| CN (1) | CN101472938A (es) |
| CA (1) | CA2654877A1 (es) |
| IL (1) | IL196773A0 (es) |
| MX (1) | MX2008015971A (es) |
| WO (1) | WO2008143677A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102006859A (zh) * | 2007-12-19 | 2011-04-06 | 光谱医药公司 | 稳定的依沙芦星盐的制剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518589A (en) * | 1983-10-03 | 1985-05-21 | Bristol-Myers Company | BBM-2478 Antibiotic complex |
| ZA923816B (en) * | 1991-05-30 | 1993-11-25 | Bristol Myers Squibb Co | Prepartion of 6-0-alkylesamicin a derivatives |
| US5508268A (en) * | 1993-08-12 | 1996-04-16 | Bristol-Myers Squibb | Parenteral elsamitrucin formulations |
-
2007
- 2007-05-24 CN CNA2007800223402A patent/CN101472938A/zh active Pending
- 2007-05-24 KR KR1020087030847A patent/KR20100014080A/ko not_active Application Discontinuation
- 2007-05-24 CA CA002654877A patent/CA2654877A1/en not_active Abandoned
- 2007-05-24 MX MX2008015971A patent/MX2008015971A/es not_active Application Discontinuation
- 2007-05-24 WO PCT/US2007/069693 patent/WO2008143677A1/en active Application Filing
-
2009
- 2009-01-28 IL IL196773A patent/IL196773A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100014080A (ko) | 2010-02-10 |
| WO2008143677A1 (en) | 2008-11-27 |
| CN101472938A (zh) | 2009-07-01 |
| IL196773A0 (en) | 2009-11-18 |
| MX2008015971A (es) | 2009-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |