CA2652216C - Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux - Google Patents
Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux Download PDFInfo
- Publication number
- CA2652216C CA2652216C CA2652216A CA2652216A CA2652216C CA 2652216 C CA2652216 C CA 2652216C CA 2652216 A CA2652216 A CA 2652216A CA 2652216 A CA2652216 A CA 2652216A CA 2652216 C CA2652216 C CA 2652216C
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- Prior art keywords
- active ingredient
- transdermal therapeutic
- therapeutic system
- inclusion bodies
- water
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- 239000000600 sorbitol Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 229940100640 transdermal system Drugs 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006026578A DE102006026578B4 (de) | 2006-06-08 | 2006-06-08 | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| DE102006026578.5 | 2006-06-08 | ||
| PCT/EP2007/004765 WO2007140909A1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2652216A1 CA2652216A1 (en) | 2007-12-13 |
| CA2652216C true CA2652216C (en) | 2016-02-16 |
Family
ID=38520773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2652216A Active CA2652216C (en) | 2006-06-08 | 2007-05-30 | Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10292942B2 (enExample) |
| EP (1) | EP2029121B1 (enExample) |
| JP (1) | JP5757682B2 (enExample) |
| CN (1) | CN101466361B (enExample) |
| AT (1) | ATE459345T1 (enExample) |
| BR (1) | BRPI0712420A2 (enExample) |
| CA (1) | CA2652216C (enExample) |
| DE (2) | DE102006026578B4 (enExample) |
| DK (1) | DK2029121T3 (enExample) |
| ES (1) | ES2340732T3 (enExample) |
| PL (1) | PL2029121T3 (enExample) |
| PT (1) | PT2029121E (enExample) |
| WO (1) | WO2007140909A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| US8369942B2 (en) * | 2008-03-20 | 2013-02-05 | The Invention Science Fund I, Llc | Subdermal material delivery device |
| JP5552255B2 (ja) | 2008-04-16 | 2014-07-16 | 日東電工株式会社 | 薬物経皮投与デバイス |
| US20110033545A1 (en) * | 2009-08-06 | 2011-02-10 | Absize, Inc. | Topical pharmaceutical preparations having both a nanoparticle solution and a nanoparticle suspension and methods for the treatment of acute and chronic pain therewith |
| DE102011100619A1 (de) | 2010-05-05 | 2012-01-05 | Amw Gmbh | Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum |
| EA201300255A1 (ru) | 2010-08-23 | 2013-06-28 | Такеда Гмбх | Увлажненные частицы, содержащие терапевтически активное вещество |
| DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
| AU2014276910B2 (en) | 2013-06-04 | 2017-03-09 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system |
| EP3209389B1 (en) | 2014-10-21 | 2019-10-02 | The Procter and Gamble Company | Kit for improving skin appearance |
| CN104758181A (zh) * | 2015-04-09 | 2015-07-08 | 史祎 | 一种无溶剂贴敷剂制备工艺 |
| CN108135786B (zh) | 2015-10-22 | 2022-05-17 | 宝洁公司 | 发泡膜的阻隔贴片和改善皮肤外观的方法 |
| US10576023B2 (en) | 2015-10-22 | 2020-03-03 | The Procter & Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
| US10751265B2 (en) * | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
| US10806681B2 (en) | 2017-01-09 | 2020-10-20 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| CN110769945B (zh) * | 2017-06-22 | 2023-01-24 | 宝洁公司 | 包括水溶性层和气相沉积涂层的美容护理品膜 |
| KR102524880B1 (ko) * | 2017-12-21 | 2023-04-21 | 한양대학교 산학협력단 | 하이드로콜로이드 조성물 및 이를 포함하는 바이오 패치 |
| WO2019183010A1 (en) | 2018-03-19 | 2019-09-26 | The Procter & Gamble Company | Method of making a barrier patch with soluble film |
| US12491166B2 (en) | 2020-08-31 | 2025-12-09 | Wacker Chemie Ag | Method of delivering an active compound and delivery device for use in the same |
| US12201733B2 (en) * | 2021-03-08 | 2025-01-21 | Nikita Patel | Transdermal delivery system |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3965482A (en) * | 1974-11-12 | 1976-06-22 | Rca Corporation | Velocity correction circuit for video discs |
| US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| US4687481A (en) | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
| DE3587616D1 (de) * | 1984-12-22 | 1993-11-11 | Sanol Arznei Schwarz Gmbh | Wirkstoffpflaster. |
| GB8629640D0 (en) | 1986-12-11 | 1987-01-21 | Beecham Group Plc | Composition & method |
| US5059189A (en) | 1987-09-08 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Method of preparing adhesive dressings containing a pharmaceutically active ingredient |
| IT1230566B (it) | 1988-10-17 | 1991-10-28 | Vectorpharma Int | Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione |
| DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
| US5270358A (en) * | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
| IT1243745B (it) * | 1990-10-17 | 1994-06-21 | Vectorpharma Int | Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione. |
| DE4332093C2 (de) * | 1993-09-22 | 1995-07-13 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung |
| JPH0912448A (ja) * | 1995-04-28 | 1997-01-14 | Read Chem Kk | 薬物放出制御型経皮吸収製剤 |
| US6238700B1 (en) | 1995-12-01 | 2001-05-29 | Alza Corporation | Method for preventing crystal formation in a dispersion of a liquid in a matrix |
| DE19652196A1 (de) | 1996-12-16 | 1998-06-18 | Jenapharm Gmbh | Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen |
| WO1999017868A1 (de) * | 1997-10-06 | 1999-04-15 | Adalbert-Raps-Stiftung | Verfahren zur herstellung eines pulverförmigen produktes aus einem flüssigen stoff oder stoffgemisch |
| DE19844079A1 (de) * | 1998-05-22 | 1999-11-25 | Novosis Pharma Ag | Biphasische Transdermalsysteme |
| DE19906152B4 (de) * | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| FI20010115A0 (fi) * | 2001-01-18 | 2001-01-18 | Orion Corp | Menetelmä nanopartikkelien valmistamiseksi |
| DE10136784A1 (de) * | 2001-07-27 | 2003-02-20 | Lohmann Therapie Syst Lts | Darreichungsformen mit wirkstoffhaltigen Partikeln, zur Anwendung auf der Haut oder Schleimhaut |
| DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
-
2006
- 2006-06-08 DE DE102006026578A patent/DE102006026578B4/de not_active Expired - Fee Related
-
2007
- 2007-05-30 CN CN200780021134XA patent/CN101466361B/zh not_active Expired - Fee Related
- 2007-05-30 CA CA2652216A patent/CA2652216C/en active Active
- 2007-05-30 BR BRPI0712420-1A patent/BRPI0712420A2/pt not_active IP Right Cessation
- 2007-05-30 JP JP2009513577A patent/JP5757682B2/ja not_active Expired - Fee Related
- 2007-05-30 DK DK07725656.8T patent/DK2029121T3/da active
- 2007-05-30 EP EP07725656A patent/EP2029121B1/de not_active Revoked
- 2007-05-30 PT PT07725656T patent/PT2029121E/pt unknown
- 2007-05-30 US US12/302,065 patent/US10292942B2/en active Active
- 2007-05-30 ES ES07725656T patent/ES2340732T3/es active Active
- 2007-05-30 PL PL07725656T patent/PL2029121T3/pl unknown
- 2007-05-30 DE DE502007003020T patent/DE502007003020D1/de active Active
- 2007-05-30 AT AT07725656T patent/ATE459345T1/de active
- 2007-05-30 WO PCT/EP2007/004765 patent/WO2007140909A1/de not_active Ceased
-
2019
- 2019-04-10 US US16/380,069 patent/US10596126B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007140909A1 (de) | 2007-12-13 |
| ATE459345T1 (de) | 2010-03-15 |
| US10596126B2 (en) | 2020-03-24 |
| JP2009539786A (ja) | 2009-11-19 |
| DE102006026578B4 (de) | 2009-01-08 |
| EP2029121B1 (de) | 2010-03-03 |
| CN101466361B (zh) | 2012-01-04 |
| DE102006026578A1 (de) | 2007-12-13 |
| DK2029121T3 (da) | 2010-06-07 |
| PT2029121E (pt) | 2010-05-11 |
| US20090258062A1 (en) | 2009-10-15 |
| BRPI0712420A2 (pt) | 2012-09-04 |
| PL2029121T3 (pl) | 2010-06-30 |
| ES2340732T3 (es) | 2010-06-08 |
| CN101466361A (zh) | 2009-06-24 |
| DE502007003020D1 (de) | 2010-04-15 |
| US10292942B2 (en) | 2019-05-21 |
| CA2652216A1 (en) | 2007-12-13 |
| EP2029121A1 (de) | 2009-03-04 |
| JP5757682B2 (ja) | 2015-07-29 |
| US20190231710A1 (en) | 2019-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |