CA2649479A1 - N-oxides of pyridylmethylpiperazine and -piperidine derivatives - Google Patents
N-oxides of pyridylmethylpiperazine and -piperidine derivatives Download PDFInfo
- Publication number
- CA2649479A1 CA2649479A1 CA002649479A CA2649479A CA2649479A1 CA 2649479 A1 CA2649479 A1 CA 2649479A1 CA 002649479 A CA002649479 A CA 002649479A CA 2649479 A CA2649479 A CA 2649479A CA 2649479 A1 CA2649479 A1 CA 2649479A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- oxide
- oxides
- nitrogen atom
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000001204 N-oxides Chemical class 0.000 title claims abstract description 79
- 150000001875 compounds Chemical class 0.000 claims abstract description 108
- 239000000203 mixture Substances 0.000 claims abstract description 44
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 36
- 238000000034 method Methods 0.000 claims abstract description 33
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 30
- 150000003839 salts Chemical class 0.000 claims abstract description 30
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 15
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- 150000004677 hydrates Chemical class 0.000 claims abstract description 10
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 7
- 238000011282 treatment Methods 0.000 claims abstract description 7
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims abstract description 5
- 125000003386 piperidinyl group Chemical group 0.000 claims abstract description 4
- 125000004193 piperazinyl group Chemical group 0.000 claims abstract description 3
- IUVSEUFHPNITEQ-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]piperazine Chemical compound C1=CC(F)=CC=C1C1=CN=CC(CN2CCN(CC2)C=2C=3OCCOC=3C=CC=2)=C1 IUVSEUFHPNITEQ-UHFFFAOYSA-N 0.000 claims description 63
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- AHQHVQAMNSTLTO-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-1-oxidopyridin-1-ium-3-yl]methyl]piperazine Chemical group C=1[N+]([O-])=CC(CN2CCN(CC2)C=2C=3OCCOC=3C=CC=2)=CC=1C1=CC=C(F)C=C1 AHQHVQAMNSTLTO-UHFFFAOYSA-N 0.000 claims description 13
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- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
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- DMGRIHSPRIYFEI-UHFFFAOYSA-N piperazine;pyridine Chemical compound C1CNCCN1.C1=CC=NC=C1 DMGRIHSPRIYFEI-UHFFFAOYSA-N 0.000 description 1
- 229960004633 pirenzepine Drugs 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79655106P | 2006-05-02 | 2006-05-02 | |
| EP06113393 | 2006-05-02 | ||
| US60/796,551 | 2006-05-02 | ||
| EP06113393.0 | 2006-05-02 | ||
| PCT/EP2007/054048 WO2007128694A1 (en) | 2006-05-02 | 2007-04-25 | N-oxides of pyridylmethylpiperazine and -piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2649479A1 true CA2649479A1 (en) | 2007-11-15 |
Family
ID=37198739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002649479A Abandoned CA2649479A1 (en) | 2006-05-02 | 2007-04-25 | N-oxides of pyridylmethylpiperazine and -piperidine derivatives |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP2024363B1 (enExample) |
| JP (1) | JP2009535374A (enExample) |
| CN (1) | CN101432279A (enExample) |
| AR (1) | AR060832A1 (enExample) |
| AU (1) | AU2007247251B2 (enExample) |
| BR (1) | BRPI0710792A2 (enExample) |
| CA (1) | CA2649479A1 (enExample) |
| CL (1) | CL2007001245A1 (enExample) |
| EA (1) | EA200870492A1 (enExample) |
| MX (1) | MX2008013887A (enExample) |
| PE (1) | PE20080064A1 (enExample) |
| SA (1) | SA07280218B1 (enExample) |
| TW (1) | TW200811150A (enExample) |
| UA (1) | UA96756C2 (enExample) |
| WO (1) | WO2007128694A1 (enExample) |
| ZA (1) | ZA200809112B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711236B (zh) * | 2007-04-12 | 2012-10-31 | Nsab神经研究瑞典公司分公司 | 表现出改善的心血管副作用特性的多巴胺受体稳定剂/调节剂的n-氧化物和/或二-n-氧化物衍生物 |
| MX347209B (es) | 2011-12-08 | 2017-04-19 | Teva Pharmaceuticals Int Gmbh | La sal de bromhidrato de pridopidina. |
| AU2013243461A1 (en) | 2012-04-04 | 2014-11-06 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for combination therapy |
| GB201801128D0 (en) | 2018-01-24 | 2018-03-07 | Univ Oxford Innovation Ltd | Compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586794T2 (de) | 1984-12-21 | 1993-05-27 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| TW530054B (en) | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
-
2007
- 2007-04-25 AU AU2007247251A patent/AU2007247251B2/en not_active Ceased
- 2007-04-25 UA UAA200813798A patent/UA96756C2/ru unknown
- 2007-04-25 EP EP07728504A patent/EP2024363B1/en active Active
- 2007-04-25 MX MX2008013887A patent/MX2008013887A/es unknown
- 2007-04-25 JP JP2009508315A patent/JP2009535374A/ja not_active Withdrawn
- 2007-04-25 WO PCT/EP2007/054048 patent/WO2007128694A1/en not_active Ceased
- 2007-04-25 CN CNA2007800157788A patent/CN101432279A/zh active Pending
- 2007-04-25 EA EA200870492A patent/EA200870492A1/ru unknown
- 2007-04-25 BR BRPI0710792-7A patent/BRPI0710792A2/pt not_active IP Right Cessation
- 2007-04-25 CA CA002649479A patent/CA2649479A1/en not_active Abandoned
- 2007-04-30 CL CL200701245A patent/CL2007001245A1/es unknown
- 2007-05-01 TW TW096115482A patent/TW200811150A/zh unknown
- 2007-05-02 PE PE2007000537A patent/PE20080064A1/es not_active Application Discontinuation
- 2007-05-02 SA SA07280218A patent/SA07280218B1/ar unknown
- 2007-05-02 AR ARP070101891A patent/AR060832A1/es not_active Application Discontinuation
-
2008
- 2008-10-23 ZA ZA200809112A patent/ZA200809112B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009535374A (ja) | 2009-10-01 |
| UA96756C2 (en) | 2011-12-12 |
| AR060832A1 (es) | 2008-07-16 |
| MX2008013887A (es) | 2009-01-29 |
| AU2007247251A1 (en) | 2007-11-15 |
| TW200811150A (en) | 2008-03-01 |
| BRPI0710792A2 (pt) | 2011-06-21 |
| EP2024363B1 (en) | 2012-08-01 |
| EA200870492A1 (ru) | 2009-04-28 |
| ZA200809112B (en) | 2009-07-29 |
| WO2007128694A1 (en) | 2007-11-15 |
| CL2007001245A1 (es) | 2008-05-30 |
| AU2007247251B2 (en) | 2011-11-03 |
| SA07280218B1 (ar) | 2010-10-03 |
| EP2024363A1 (en) | 2009-02-18 |
| PE20080064A1 (es) | 2008-03-19 |
| CN101432279A (zh) | 2009-05-13 |
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| Date | Code | Title | Description |
|---|---|---|---|
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| FZDE | Discontinued |
Effective date: 20140425 |