CA2648648A1 - Dermis-derived cells for tissue engineering applications - Google Patents

Dermis-derived cells for tissue engineering applications Download PDF

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Publication number
CA2648648A1
CA2648648A1 CA002648648A CA2648648A CA2648648A1 CA 2648648 A1 CA2648648 A1 CA 2648648A1 CA 002648648 A CA002648648 A CA 002648648A CA 2648648 A CA2648648 A CA 2648648A CA 2648648 A1 CA2648648 A1 CA 2648648A1
Authority
CA
Canada
Prior art keywords
cells
aggrecan
asid
tissue
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002648648A
Other languages
English (en)
French (fr)
Inventor
Kyriacos A. Athanasiou
Ying Deng
Jerry Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Kyriacos A. Athanasiou
Ying Deng
Jerry Hu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University, Kyriacos A. Athanasiou, Ying Deng, Jerry Hu filed Critical William Marsh Rice University
Publication of CA2648648A1 publication Critical patent/CA2648648A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar
CA002648648A 2006-04-05 2007-04-05 Dermis-derived cells for tissue engineering applications Abandoned CA2648648A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US78985106P 2006-04-05 2006-04-05
US78985306P 2006-04-05 2006-04-05
US78985506P 2006-04-05 2006-04-05
US60/789,851 2006-04-05
US60/789,853 2006-04-05
US60/789,855 2006-04-05
PCT/US2007/066085 WO2007136936A2 (en) 2006-04-05 2007-04-05 Dermis-derived cells for tissue engineering applications

Publications (1)

Publication Number Publication Date
CA2648648A1 true CA2648648A1 (en) 2007-11-29

Family

ID=38564326

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002648648A Abandoned CA2648648A1 (en) 2006-04-05 2007-04-05 Dermis-derived cells for tissue engineering applications
CA002648332A Abandoned CA2648332A1 (en) 2006-04-05 2007-04-05 A shape-based approach for scaffoldless tissue engineering
CA002648327A Abandoned CA2648327A1 (en) 2006-04-05 2007-04-05 Tissue engineering with human embryonic stem cells

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA002648332A Abandoned CA2648332A1 (en) 2006-04-05 2007-04-05 A shape-based approach for scaffoldless tissue engineering
CA002648327A Abandoned CA2648327A1 (en) 2006-04-05 2007-04-05 Tissue engineering with human embryonic stem cells

Country Status (4)

Country Link
EP (3) EP2007875A4 (de)
AU (3) AU2007234366A1 (de)
CA (3) CA2648648A1 (de)
WO (3) WO2007115336A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2338442B1 (de) 2003-12-11 2013-01-30 Isto Technologies Inc. Teilchenförmiges Knorpelsystem
US8241905B2 (en) 2004-02-24 2012-08-14 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
WO2010022074A1 (en) * 2008-08-18 2010-02-25 William Marsh Rice University A decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
US20110212894A1 (en) * 2004-07-09 2011-09-01 Athanasiou Kyriacos A Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
WO2007025290A2 (en) 2005-08-26 2007-03-01 Isto Technologies, Inc. Implants and methods for repair, replacement and treatment of joint disease
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
JP2011512992A (ja) * 2008-03-03 2011-04-28 ウイリアム、マーシュ、ライス、ユーニヴァーサティ 改良された組織工学的に作製された軟骨を組み立てる方法
US9303245B2 (en) * 2008-06-20 2016-04-05 Universiteit Maastricht Self-assembling tissue modules
CA2949615A1 (en) 2008-06-24 2010-01-21 The Curators Of The University Of Missouri Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
US8685386B2 (en) * 2009-07-16 2014-04-01 Biotime, Inc Methods and compositions for in vitro and in vivo chondrogenesis
BR112013009744A2 (pt) 2010-10-21 2016-07-19 Organovo Inc dispositivo, sistemas e métodos para a fabricação de tecido
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
WO2015017579A1 (en) 2013-07-31 2015-02-05 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
CA3177480A1 (en) 2014-04-04 2015-10-08 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
US9670443B2 (en) 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs
MA40495A (fr) 2014-10-06 2016-04-14 Organovo Inc Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production
US11529436B2 (en) 2014-11-05 2022-12-20 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5944754A (en) * 1995-11-09 1999-08-31 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
IL145151A0 (en) * 1999-03-02 2002-06-30 Univ Massachusetts Embr0yonic or stem-like cell lines produced by cross species nuclear transplantation
IL154159A0 (en) * 2000-08-01 2003-07-31 Yissum Res Dev Co Directed differentiation of ebryonic cells
US20020132346A1 (en) * 2001-03-08 2002-09-19 Jose Cibelli Use of RNA interference for the creation of lineage specific ES and other undifferentiated cells and production of differentiated cells in vitro by co-culture
US20030109038A1 (en) * 2001-12-07 2003-06-12 Thies R. Scott Chondrocyte precursors derived from human embryonic stem cells
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
WO2003084385A2 (en) * 2002-04-02 2003-10-16 William Marsh Rice University Redifferentiated cells for repairing cartilage defects
US20040082063A1 (en) * 2002-10-18 2004-04-29 Reliance Life Sciences Pvt. Ltd. Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture
EP1819290B1 (de) * 2004-07-09 2011-03-02 William Marsh Rice University Gerüstlose konstrukte für die erzeugung von gelenkknorpel aus gewebe

Also Published As

Publication number Publication date
WO2007136936A2 (en) 2007-11-29
WO2007115337A8 (en) 2007-12-13
EP2007875A4 (de) 2009-12-16
EP2007881A4 (de) 2009-07-08
CA2648332A1 (en) 2007-10-11
EP2007875A2 (de) 2008-12-31
WO2007115337A2 (en) 2007-10-11
WO2007115336A3 (en) 2008-05-22
AU2007234366A1 (en) 2007-10-11
WO2007115337A3 (en) 2008-07-03
EP2007312A4 (de) 2012-08-22
WO2007136936A3 (en) 2008-10-23
AU2007254048A1 (en) 2007-11-29
WO2007115336A2 (en) 2007-10-11
AU2007234365A1 (en) 2007-10-11
CA2648327A1 (en) 2007-10-11
EP2007312A2 (de) 2008-12-31
EP2007881A2 (de) 2008-12-31

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