CA2640058C - Oligomeric compounds and compositions for the use in modulation of micrornas - Google Patents

Oligomeric compounds and compositions for the use in modulation of micrornas Download PDF

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Publication number
CA2640058C
CA2640058C CA2640058A CA2640058A CA2640058C CA 2640058 C CA2640058 C CA 2640058C CA 2640058 A CA2640058 A CA 2640058A CA 2640058 A CA2640058 A CA 2640058A CA 2640058 C CA2640058 C CA 2640058C
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moe
formula
oligomeric compound
dna
artificial sequence
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French (fr)
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CA2640058A1 (en
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Christine Esau
Eric E. Swayze
Balkrishen Bhat
Garth A. Kinberger
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/11Antisense
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
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    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity
    • C12N2320/51Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2640058A 2006-01-27 2007-01-27 Oligomeric compounds and compositions for the use in modulation of micrornas Active CA2640058C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76272106P 2006-01-27 2006-01-27
US60/762,721 2006-01-27
US80520406P 2006-06-19 2006-06-19
US60/805,204 2006-06-19
PCT/US2007/061186 WO2007090073A2 (en) 2006-01-27 2007-01-27 Oligomeric compounds and compositions for the use in modulation of micrornas

Publications (2)

Publication Number Publication Date
CA2640058A1 CA2640058A1 (en) 2007-08-09
CA2640058C true CA2640058C (en) 2018-04-24

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CA2640058A Active CA2640058C (en) 2006-01-27 2007-01-27 Oligomeric compounds and compositions for the use in modulation of micrornas

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US (3) US8129515B2 (enExample)
EP (3) EP2388327A1 (enExample)
JP (1) JP5213723B2 (enExample)
AU (1) AU2007211082B2 (enExample)
CA (1) CA2640058C (enExample)
WO (1) WO2007090073A2 (enExample)

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