CA2632578A1 - Miniature toroidal radio frequency ion trap mass analyzer - Google Patents
Miniature toroidal radio frequency ion trap mass analyzer Download PDFInfo
- Publication number
- CA2632578A1 CA2632578A1 CA002632578A CA2632578A CA2632578A1 CA 2632578 A1 CA2632578 A1 CA 2632578A1 CA 002632578 A CA002632578 A CA 002632578A CA 2632578 A CA2632578 A CA 2632578A CA 2632578 A1 CA2632578 A1 CA 2632578A1
- Authority
- CA
- Canada
- Prior art keywords
- ions
- detector
- endcap
- mass analyzer
- trapping volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000005040 ion trap Methods 0.000 title claims abstract description 84
- 150000002500 ions Chemical class 0.000 claims description 133
- 238000000034 method Methods 0.000 claims description 69
- 239000002245 particle Substances 0.000 claims description 48
- 238000001514 detection method Methods 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims 9
- 238000010276 construction Methods 0.000 abstract 1
- 238000003860 storage Methods 0.000 description 13
- 238000001228 spectrum Methods 0.000 description 10
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
- 238000003754 machining Methods 0.000 description 7
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- OCKPCBLVNKHBMX-UHFFFAOYSA-N butylbenzene Chemical compound CCCCC1=CC=CC=C1 OCKPCBLVNKHBMX-UHFFFAOYSA-N 0.000 description 6
- 238000004949 mass spectrometry Methods 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000012937 correction Methods 0.000 description 5
- 238000013461 design Methods 0.000 description 4
- 229910052724 xenon Inorganic materials 0.000 description 4
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 230000002939 deleterious effect Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 229910000619 316 stainless steel Inorganic materials 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000282881 Orycteropodidae Species 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011842 forensic investigation Methods 0.000 description 1
- 239000002117 illicit drug Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920003223 poly(pyromellitimide-1,4-diphenyl ether) Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/424—Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
- H01J49/423—Two-dimensional RF ion traps with radial ejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D59/00—Separation of different isotopes of the same chemical element
- B01D59/44—Separation by mass spectrography
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75027705P | 2005-12-13 | 2005-12-13 | |
| US60/750,277 | 2005-12-13 | ||
| PCT/US2006/047828 WO2007089339A2 (en) | 2005-12-13 | 2006-12-13 | Miniature toroidal radio frequency ion trap mass analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2632578A1 true CA2632578A1 (en) | 2007-08-09 |
Family
ID=38327834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002632578A Abandoned CA2632578A1 (en) | 2005-12-13 | 2006-12-13 | Miniature toroidal radio frequency ion trap mass analyzer |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9053919B2 (enExample) |
| EP (1) | EP1960090B1 (enExample) |
| JP (2) | JP5491734B2 (enExample) |
| CN (1) | CN101330965B (enExample) |
| CA (1) | CA2632578A1 (enExample) |
| WO (1) | WO2007089339A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201103361D0 (en) * | 2011-02-28 | 2011-04-13 | Shimadzu Corp | Mass analyser and method of mass analysis |
| WO2013039772A1 (en) | 2011-09-16 | 2013-03-21 | Waters Technologies Corporation | Techniques for automated performance maintenance testing and reporting for analytical instruments |
| WO2014149846A2 (en) | 2013-03-15 | 2014-09-25 | 1St Detect Corporation | A mass spectrometer system having an external detector |
| US8878127B2 (en) * | 2013-03-15 | 2014-11-04 | The University Of North Carolina Of Chapel Hill | Miniature charged particle trap with elongated trapping region for mass spectrometry |
| CN103928288B (zh) * | 2014-04-17 | 2017-01-04 | 复旦大学 | 一种用于离子储存与质量分析的三角形圆环离子阱 |
| US9711341B2 (en) * | 2014-06-10 | 2017-07-18 | The University Of North Carolina At Chapel Hill | Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods |
| CN104900474B (zh) * | 2015-05-26 | 2017-02-01 | 清华大学深圳研究生院 | 一种串联离子阱 |
| CN105632864B (zh) * | 2016-01-07 | 2017-11-17 | 中国计量科学研究院 | 一种复合检测器及具有该检测器的四极质谱仪 |
| CA3039916A1 (en) | 2016-10-10 | 2018-04-19 | Perkinelmer Health Sciences, Inc. | Sampling pumps and closed loop control of sampling pumps to load traps |
| US10242857B2 (en) | 2017-08-31 | 2019-03-26 | The University Of North Carolina At Chapel Hill | Ion traps with Y-directional ion manipulation for mass spectrometry and related mass spectrometry systems and methods |
| US20230253199A1 (en) * | 2022-02-04 | 2023-08-10 | Perkinelmer Health Sciences, Inc. | Toroidal ion trap |
| US20240222106A1 (en) * | 2022-12-29 | 2024-07-04 | Thermo Finnigan Llc | Apparatus and Method for Ion Separation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4324224C1 (de) * | 1993-07-20 | 1994-10-06 | Bruker Franzen Analytik Gmbh | Quadrupol-Ionenfallen mit schaltbaren Multipol-Anteilen |
| US5420425A (en) * | 1994-05-27 | 1995-05-30 | Finnigan Corporation | Ion trap mass spectrometer system and method |
| US5650617A (en) * | 1996-07-30 | 1997-07-22 | Varian Associates, Inc. | Method for trapping ions into ion traps and ion trap mass spectrometer system thereof |
| JP3656239B2 (ja) * | 1997-01-28 | 2005-06-08 | 株式会社島津製作所 | イオントラップ質量分析装置 |
| JP3617662B2 (ja) * | 1997-02-28 | 2005-02-09 | 株式会社島津製作所 | 質量分析装置 |
| JP3650551B2 (ja) | 1999-09-14 | 2005-05-18 | 株式会社日立製作所 | 質量分析計 |
| US6762406B2 (en) * | 2000-05-25 | 2004-07-13 | Purdue Research Foundation | Ion trap array mass spectrometer |
| AU2002305449A1 (en) * | 2001-05-08 | 2002-11-18 | Thermo Finnigan Llc | Ion trap |
| US6770871B1 (en) * | 2002-05-31 | 2004-08-03 | Michrom Bioresources, Inc. | Two-dimensional tandem mass spectrometry |
| CN1829911B (zh) * | 2003-06-20 | 2011-04-20 | 杨百翰大学 | 用于离子迁移率和离子阱质谱分析的单一装置 |
| US7217922B2 (en) * | 2005-03-14 | 2007-05-15 | Lucent Technologies Inc. | Planar micro-miniature ion trap devices |
| US7180057B1 (en) * | 2005-08-04 | 2007-02-20 | Thermo Finnigan Llc | Two-dimensional quadrupole ion trap |
| US20100163724A1 (en) * | 2008-12-30 | 2010-07-01 | University Of North Texas | Applications of hydrogen gas getters in mass spectrometry |
-
2006
- 2006-12-13 US US11/639,373 patent/US9053919B2/en active Active
- 2006-12-13 EP EP06849962.3A patent/EP1960090B1/en active Active
- 2006-12-13 JP JP2008545830A patent/JP5491734B2/ja active Active
- 2006-12-13 WO PCT/US2006/047828 patent/WO2007089339A2/en not_active Ceased
- 2006-12-13 CA CA002632578A patent/CA2632578A1/en not_active Abandoned
- 2006-12-13 CN CN2006800470443A patent/CN101330965B/zh active Active
-
2013
- 2013-12-27 JP JP2013271795A patent/JP5805746B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007089339A2 (en) | 2007-08-09 |
| EP1960090A2 (en) | 2008-08-27 |
| CN101330965A (zh) | 2008-12-24 |
| JP2009519584A (ja) | 2009-05-14 |
| JP5805746B2 (ja) | 2015-11-04 |
| EP1960090B1 (en) | 2018-10-10 |
| CN101330965B (zh) | 2012-05-30 |
| JP5491734B2 (ja) | 2014-05-14 |
| JP2014078532A (ja) | 2014-05-01 |
| US9053919B2 (en) | 2015-06-09 |
| WO2007089339A3 (en) | 2008-04-03 |
| EP1960090A4 (en) | 2011-12-21 |
| US20120267523A1 (en) | 2012-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20131213 |