CA2631876C - Aminophenyl derivatives as inhibitors of histone deacetylase - Google Patents

Aminophenyl derivatives as inhibitors of histone deacetylase Download PDF

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Publication number
CA2631876C
CA2631876C CA2631876A CA2631876A CA2631876C CA 2631876 C CA2631876 C CA 2631876C CA 2631876 A CA2631876 A CA 2631876A CA 2631876 A CA2631876 A CA 2631876A CA 2631876 C CA2631876 C CA 2631876C
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Canada
Prior art keywords
6alkyl
compound
hydrogen
compounds
amino
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CA2631876A
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English (en)
French (fr)
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CA2631876A1 (en
Inventor
Patrick Rene Angibaud
Isabelle Noelle Constance Pilatte
Bruno Roux
Janine Arts
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CA2631876A1 publication Critical patent/CA2631876A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2631876A 2006-01-19 2007-01-16 Aminophenyl derivatives as inhibitors of histone deacetylase Active CA2631876C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06100584.9 2006-01-19
EP06100584 2006-01-19
PCT/EP2007/050376 WO2007082878A1 (en) 2006-01-19 2007-01-16 Aminophenyl derivatives as novel inhibitors of histone deacetylase

Publications (2)

Publication Number Publication Date
CA2631876A1 CA2631876A1 (en) 2007-07-26
CA2631876C true CA2631876C (en) 2014-05-27

Family

ID=36579211

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2631876A Active CA2631876C (en) 2006-01-19 2007-01-16 Aminophenyl derivatives as inhibitors of histone deacetylase

Country Status (18)

Country Link
US (1) US8119650B2 (https=)
EP (1) EP1981874B1 (https=)
JP (1) JP5225104B2 (https=)
CN (1) CN101370804B (https=)
AT (1) ATE432272T1 (https=)
AU (1) AU2007206946B2 (https=)
CA (1) CA2631876C (https=)
CY (1) CY1109331T1 (https=)
DE (1) DE602007001190D1 (https=)
DK (1) DK1981874T3 (https=)
ES (1) ES2327972T3 (https=)
HR (1) HRP20090459T1 (https=)
ME (1) ME01060B (https=)
PL (1) PL1981874T3 (https=)
PT (1) PT1981874E (https=)
RS (1) RS51191B (https=)
SI (1) SI1981874T1 (https=)
WO (1) WO2007082878A1 (https=)

Families Citing this family (23)

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EA007099B1 (ru) 2002-03-13 2006-06-30 Янссен Фармацевтика Н. В. Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы
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RS51189B (sr) * 2004-07-28 2010-10-31 Janssen Pharmaceutica N.V. Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze
ES2553178T3 (es) 2005-05-18 2015-12-04 Janssen Pharmaceutica N.V. Derivados sustituidos de aminopropenil piperidina o morfolina como nuevos inhibidores de histona deacetilasa
JP5070214B2 (ja) * 2005-10-27 2012-11-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの阻害剤としてのスクエア酸誘導体
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EP1981875B1 (en) * 2006-01-19 2014-04-16 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
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WO2007082874A1 (en) * 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
CA2631876C (en) 2006-01-19 2014-05-27 Janssen Pharmaceutica N.V. Aminophenyl derivatives as inhibitors of histone deacetylase
WO2009118370A1 (en) * 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
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Also Published As

Publication number Publication date
EP1981874B1 (en) 2009-05-27
PT1981874E (pt) 2009-09-02
CN101370804B (zh) 2013-05-29
RS51191B (sr) 2010-10-31
AU2007206946A1 (en) 2007-07-26
CA2631876A1 (en) 2007-07-26
ME01060B (me) 2012-10-20
JP2009523760A (ja) 2009-06-25
SI1981874T1 (sl) 2009-10-31
WO2007082878A1 (en) 2007-07-26
HRP20090459T1 (hr) 2009-09-30
DK1981874T3 (da) 2009-09-28
US20090018152A1 (en) 2009-01-15
ATE432272T1 (de) 2009-06-15
CN101370804A (zh) 2009-02-18
AU2007206946B2 (en) 2011-12-15
ES2327972T3 (es) 2009-11-05
US8119650B2 (en) 2012-02-21
PL1981874T3 (pl) 2009-10-30
JP5225104B2 (ja) 2013-07-03
CY1109331T1 (el) 2014-07-02
EP1981874A1 (en) 2008-10-22
HK1128283A1 (en) 2009-10-23
DE602007001190D1 (de) 2009-07-09

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