CA2631422A1 - Zinc finger binding domains for tnn - Google Patents
Zinc finger binding domains for tnn Download PDFInfo
- Publication number
- CA2631422A1 CA2631422A1 CA002631422A CA2631422A CA2631422A1 CA 2631422 A1 CA2631422 A1 CA 2631422A1 CA 002631422 A CA002631422 A CA 002631422A CA 2631422 A CA2631422 A CA 2631422A CA 2631422 A1 CA2631422 A1 CA 2631422A1
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- seq
- binding
- amino acid
- polypeptide
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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| US74052505P | 2005-11-28 | 2005-11-28 | |
| US60/740,525 | 2005-11-28 | ||
| PCT/US2006/061289 WO2007062422A2 (en) | 2005-11-28 | 2006-11-28 | Zinc finger binding domains for tnn |
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| CA2631422A1 true CA2631422A1 (en) | 2007-05-31 |
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| JP (1) | JP2009520463A (enExample) |
| CA (1) | CA2631422A1 (enExample) |
| WO (1) | WO2007062422A2 (enExample) |
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| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| CA2631422A1 (en) | 2005-11-28 | 2007-05-31 | The Scripps Research Institute | Zinc finger binding domains for tnn |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| JP5173838B2 (ja) | 2006-02-13 | 2013-04-03 | アレシア・バイオセラピューティクス・インコーポレーテッド | 骨リモデリングのプロセスと関係があるポリヌクレオチドおよびポリペプチド配列 |
| US20090081786A1 (en) * | 2006-06-30 | 2009-03-26 | Viktoria Kheifets | Peptide sequences for modulation of protein kinase C |
| ES2585157T3 (es) * | 2007-09-27 | 2016-10-04 | Dow Agrosciences Llc | Proteínas de dedo de cinc de diseño que se dirigen a los genes de 5-enolpiruvil shikimato-3-fosfato sintasa |
| PL2274430T3 (pl) | 2008-04-30 | 2017-09-29 | Sanbio Inc | Komórki regenerujące nerwy ze zmianami w metylacji DNA |
| WO2010056808A2 (en) * | 2008-11-12 | 2010-05-20 | The Regents Of The University Of California | Compositions and methods for re-programming and re-differentiating cells |
| NZ598457A (en) | 2009-08-03 | 2014-06-27 | Recombinetics Inc | Methods and compositions for targeted gene modification |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| US20140186340A1 (en) | 2011-04-08 | 2014-07-03 | Gilead Biologics, Inc. | Methods and Compositions for Normalization of Tumor Vasculature by Inhibition of LOXL2 |
| JP6023218B2 (ja) | 2012-01-27 | 2016-11-09 | サンバイオ，インコーポレイティド | 血管新生及び血管発生を調節するための方法及び組成物 |
| US11120889B2 (en) | 2012-05-09 | 2021-09-14 | Georgia Tech Research Corporation | Method for synthesizing a nuclease with reduced off-site cleavage |
| AU2013293062A1 (en) | 2012-07-19 | 2014-07-24 | Alethia Biotherapeutics Inc. | Anti-Siglec-15 antibodies |
| CN105408483A (zh) | 2013-03-15 | 2016-03-16 | 通用医疗公司 | 遗传和表观遗传调节蛋白至特定基因组基因座的rna引导的靶向 |
| WO2014186435A2 (en) | 2013-05-14 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Compositions and methods for reducing neointima formation |
| US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
| EP3721875B1 (en) | 2014-05-09 | 2023-11-08 | Yale University | Particles coated with hyperbranched polyglycerol and methods for their preparation |
| JP2019508037A (ja) | 2016-02-16 | 2019-03-28 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ | 標的化遺伝子編集を増強するための組成物およびその使用方法 |
| AU2017221424A1 (en) | 2016-02-16 | 2018-09-20 | Yale University | Compositions and methods for treatment of cystic fibrosis |
| WO2017173453A1 (en) | 2016-04-01 | 2017-10-05 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
| US11410746B2 (en) | 2016-04-27 | 2022-08-09 | Massachusetts Institute Of Technology | Stable nanoscale nucleic acid assemblies and methods thereof |
| US11514331B2 (en) | 2016-04-27 | 2022-11-29 | Massachusetts Institute Of Technology | Sequence-controlled polymer random access memory storage |
| US11766400B2 (en) | 2016-10-24 | 2023-09-26 | Yale University | Biodegradable contraceptive implants |
| US11371023B2 (en) * | 2016-11-22 | 2022-06-28 | Wisconsin Alumni Research Foundation | Artificial transcription factors and uses thereof |
| WO2018112470A1 (en) | 2016-12-16 | 2018-06-21 | The Brigham And Women's Hospital, Inc. | Co-delivery of nucleic acids for simultaneous suppression and expression of target genes |
| WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
| EP3612204A4 (en) | 2017-04-21 | 2021-01-27 | The General Hospital Corporation | INDUCTIBLE, TUNING AND MULTIPLEX HUMAN GENE REGULATION USING CRISPR-CPF1 |
| WO2019094928A1 (en) | 2017-11-10 | 2019-05-16 | Massachusetts Institute Of Technology | Microbial production of pure single stranded nucleic acids |
| US10953036B2 (en) | 2017-11-20 | 2021-03-23 | University Of Georgia Research Foundation, Inc. | Compositions and methods of modulating HIF-2A to improve muscle generation and repair |
| CA3100726A1 (en) | 2018-05-17 | 2019-11-21 | The General Hospital Corporation | Ccctc-binding factor variants |
| US11939593B2 (en) | 2018-08-01 | 2024-03-26 | University Of Georgia Research Foundation, Inc. | Compositions and methods for improving embryo development |
| EP3844287B1 (en) | 2018-08-31 | 2024-05-22 | Yale University | Compositions and methods for enhancing donor oligonucleotide-based gene editing |
| BR112021003823A2 (pt) | 2018-08-31 | 2021-05-25 | Yale University | composição, composição farmacêutica e método para modificar o genoma de uma célula |
| WO2020112195A1 (en) | 2018-11-30 | 2020-06-04 | Yale University | Compositions, technologies and methods of using plerixafor to enhance gene editing |
| WO2020154595A1 (en) | 2019-01-24 | 2020-07-30 | Massachusetts Institute Of Technology | Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom |
| US12642850B2 (en) | 2019-01-24 | 2026-06-02 | Massachusetts Institute Of Technology | Nucleic acid nanostructure platform for programming immune stimulation |
| US11905532B2 (en) | 2019-06-25 | 2024-02-20 | Massachusetts Institute Of Technology | Compositions and methods for molecular memory storage and retrieval |
| KR20220101073A (ko) | 2019-08-30 | 2022-07-19 | 예일 유니버시티 | 핵산을 세포로 전달하기 위한 조성물 및 방법 |
| AU2021286555B2 (en) | 2020-06-09 | 2025-04-03 | Cold Spring Harbor Laboratory | Heterozygous CENH3 monocots and methods of use thereof for haploid induction and simultaneous genome editing |
| WO2022047424A1 (en) | 2020-08-31 | 2022-03-03 | Yale University | Compositions and methods for delivery of nucleic acids to cells |
| CN117321197A (zh) | 2021-01-12 | 2023-12-29 | 马奇疗法公司 | 背景依赖性、双链dna特异性脱氨酶及其用途 |
| WO2022170117A1 (en) * | 2021-02-04 | 2022-08-11 | New York University | Seamless integration of engineered zinc fingers into endogenous transcription factors to commandeer their natural functions |
| WO2023070043A1 (en) | 2021-10-20 | 2023-04-27 | Yale University | Compositions and methods for targeted editing and evolution of repetitive genetic elements |
| WO2023192872A1 (en) | 2022-03-28 | 2023-10-05 | Massachusetts Institute Of Technology | Rna scaffolded wireframe origami and methods thereof |
| JP2025523965A (ja) | 2022-07-22 | 2025-07-25 | ザ・ジョンズ・ホプキンス・ユニバーシティー | デンドリマーが可能にする標的化細胞内ｃｒｉｓｐｒ／ｃａｓシステム送達および遺伝子編集 |
| JP2025536260A (ja) | 2022-10-11 | 2025-11-05 | イェール ユニバーシティー | 細胞透過性抗体の組成物および使用方法 |
| CN120641131A (zh) | 2022-12-01 | 2025-09-12 | 耶鲁大学 | 用于细胞内有效载荷递送的刺激反应性无痕工程化平台 |
| WO2025224715A1 (en) | 2024-04-26 | 2025-10-30 | King Abdullah Univeristy Of Science And Technology | Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing |
| WO2026006832A1 (en) | 2024-06-28 | 2026-01-02 | University Of Connecticut | Gene modulation for treating cancer |
| WO2026122879A1 (en) | 2024-12-05 | 2026-06-11 | Massachusetts Institute Of Technology | Compositions and methods for producing endotoxin-free phage |
| WO2026128588A1 (en) | 2024-12-10 | 2026-06-18 | Yale University | Compositions and methods for treating fibrosis |
Family Cites Families (12)
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| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| JP3393867B2 (ja) | 1989-11-13 | 2003-04-07 | マサチユーセツツ・インステイテユート・オブ・テクノロジー | ウィルムス腫瘍遺伝子の位置決定と特徴付け |
| JP4012243B2 (ja) | 1994-01-18 | 2007-11-21 | ザ スクリップス リサーチ インスティチュート | 亜鉛フィンガータンパク質誘導体およびそのための方法 |
| CA2196419C (en) | 1994-08-20 | 2007-08-21 | Yen Choo | Improvements in or relating to binding proteins for recognition of dna |
| US5789538A (en) * | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6599692B1 (en) * | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US7067617B2 (en) * | 2001-02-21 | 2006-06-27 | The Scripps Research Institute | Zinc finger binding domains for nucleotide sequence ANN |
| US20040224385A1 (en) * | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
| AU2003215094B2 (en) * | 2002-02-07 | 2008-05-29 | The Scripps Research Institute | Zinc finger libraries |
| CA2631422A1 (en) | 2005-11-28 | 2007-05-31 | The Scripps Research Institute | Zinc finger binding domains for tnn |
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2006
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- 2006-11-28 US US11/564,141 patent/US7833784B2/en not_active Expired - Fee Related
- 2006-11-28 EP EP06846383A patent/EP1963499A4/en not_active Ceased
- 2006-11-28 JP JP2008542539A patent/JP2009520463A/ja active Pending
- 2006-11-28 WO PCT/US2006/061289 patent/WO2007062422A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009520463A (ja) | 2009-05-28 |
| EP1963499A2 (en) | 2008-09-03 |
| WO2007062422A2 (en) | 2007-05-31 |
| WO2007062422A3 (en) | 2008-10-23 |
| US20070213269A1 (en) | 2007-09-13 |
| US7833784B2 (en) | 2010-11-16 |
| EP1963499A4 (en) | 2009-04-08 |
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