CA2631082C - Oncogenic ras-specific cytotoxic compound and methods of use thereof - Google Patents

Oncogenic ras-specific cytotoxic compound and methods of use thereof Download PDF

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Publication number
CA2631082C
CA2631082C CA2631082A CA2631082A CA2631082C CA 2631082 C CA2631082 C CA 2631082C CA 2631082 A CA2631082 A CA 2631082A CA 2631082 A CA2631082 A CA 2631082A CA 2631082 C CA2631082 C CA 2631082C
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CA
Canada
Prior art keywords
butyl
oncrasin
methyl
group
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2631082A
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English (en)
French (fr)
Other versions
CA2631082A1 (en
Inventor
Bingliang Fang
Jinsong Liu
Wei Guo
Shuhong Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
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University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of CA2631082A1 publication Critical patent/CA2631082A1/en
Application granted granted Critical
Publication of CA2631082C publication Critical patent/CA2631082C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2631082A 2005-11-23 2006-11-22 Oncogenic ras-specific cytotoxic compound and methods of use thereof Expired - Fee Related CA2631082C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73986505P 2005-11-23 2005-11-23
US60/739,865 2005-11-23
PCT/US2006/061219 WO2007062399A2 (en) 2005-11-23 2006-11-22 Oncogenic ras-specific cytotoxic compound and methods of use thereof

Publications (2)

Publication Number Publication Date
CA2631082A1 CA2631082A1 (en) 2007-05-31
CA2631082C true CA2631082C (en) 2015-02-03

Family

ID=38068056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2631082A Expired - Fee Related CA2631082C (en) 2005-11-23 2006-11-22 Oncogenic ras-specific cytotoxic compound and methods of use thereof

Country Status (8)

Country Link
US (1) US8883841B2 (https=)
EP (1) EP1956910B1 (https=)
JP (1) JP5460054B2 (https=)
CN (1) CN101360422B (https=)
AU (1) AU2006318212C1 (https=)
CA (1) CA2631082C (https=)
RU (1) RU2448703C2 (https=)
WO (1) WO2007062399A2 (https=)

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US9095572B2 (en) 2009-01-09 2015-08-04 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
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US9474730B2 (en) * 2012-04-30 2016-10-25 Board Of Regents Of The University Of Texas System Methods and compositions for use with K-ras mediated disorders
AU2013305591B2 (en) 2012-08-24 2017-04-13 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CN104903308B (zh) 2013-01-10 2018-06-08 默克专利股份有限公司 作为抗疟药的哌啶基咔唑类
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WO2015070234A2 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective compounds and use thereof
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KR102428024B1 (ko) * 2020-06-11 2022-08-03 충북대학교 산학협력단 프로카스파제-3의 활성화제로서 신규한 (e)-n-아릴리덴-1-(4-클로로벤질)-1h-인돌-3-카보하이드라지드 및 이를 유효성분으로 포함하는 항암제 조성물
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Also Published As

Publication number Publication date
AU2006318212A1 (en) 2007-05-31
AU2006318212B2 (en) 2012-01-12
RU2008125065A (ru) 2009-12-27
CA2631082A1 (en) 2007-05-31
EP1956910A2 (en) 2008-08-20
JP5460054B2 (ja) 2014-04-02
CN101360422A (zh) 2009-02-04
EP1956910A4 (en) 2010-03-24
US8883841B2 (en) 2014-11-11
CN101360422B (zh) 2013-10-23
WO2007062399A2 (en) 2007-05-31
WO2007062399A3 (en) 2007-12-21
US20090286847A1 (en) 2009-11-19
JP2009517401A (ja) 2009-04-30
AU2006318212C1 (en) 2012-08-30
EP1956910B1 (en) 2014-09-17
RU2448703C2 (ru) 2012-04-27

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