CA2630839C - Therapeutic methods for inhibiting tumor growth with dll4 antagonists - Google Patents
Therapeutic methods for inhibiting tumor growth with dll4 antagonists Download PDFInfo
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- CA2630839C CA2630839C CA2630839A CA2630839A CA2630839C CA 2630839 C CA2630839 C CA 2630839C CA 2630839 A CA2630839 A CA 2630839A CA 2630839 A CA2630839 A CA 2630839A CA 2630839 C CA2630839 C CA 2630839C
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Classifications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75117305P | 2005-12-16 | 2005-12-16 | |
| US60/751,173 | 2005-12-16 | ||
| US77127606P | 2006-02-08 | 2006-02-08 | |
| US60/771,276 | 2006-02-08 | ||
| US78845606P | 2006-03-31 | 2006-03-31 | |
| US60/788,456 | 2006-03-31 | ||
| US83054306P | 2006-07-12 | 2006-07-12 | |
| US60/830,543 | 2006-07-12 | ||
| PCT/US2006/047848 WO2007070671A2 (en) | 2005-12-16 | 2006-12-15 | Therapeutic methods for inhibiting tumor growth with dll4 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2630839A1 CA2630839A1 (en) | 2007-06-21 |
| CA2630839C true CA2630839C (en) | 2017-01-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2630839A Expired - Fee Related CA2630839C (en) | 2005-12-16 | 2006-12-15 | Therapeutic methods for inhibiting tumor growth with dll4 antagonists |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080107648A1 (OSRAM) |
| EP (1) | EP1962895B2 (OSRAM) |
| JP (1) | JP5489465B2 (OSRAM) |
| AU (1) | AU2006326417B2 (OSRAM) |
| CA (1) | CA2630839C (OSRAM) |
| DK (1) | DK1962895T3 (OSRAM) |
| ES (1) | ES2400666T5 (OSRAM) |
| IL (1) | IL191810A (OSRAM) |
| NZ (1) | NZ568739A (OSRAM) |
| PL (1) | PL1962895T3 (OSRAM) |
| PT (1) | PT1962895E (OSRAM) |
| WO (1) | WO2007070671A2 (OSRAM) |
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| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US7906116B2 (en) * | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
| US20080014196A1 (en) * | 2006-06-06 | 2008-01-17 | Genentech, Inc. | Compositions and methods for modulating vascular development |
| AU2007319672B2 (en) | 2006-06-06 | 2011-06-30 | Genentech, Inc. | Anti-DLL4 antibodies and methods using same |
| HUE028379T2 (en) * | 2006-09-29 | 2016-12-28 | Oncomed Pharm Inc | Preparations and procedures for the diagnosis and treatment of cancer |
| CA2666179A1 (en) | 2006-10-19 | 2008-11-13 | Genentech, Inc. | Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease |
| CA2666672A1 (en) * | 2006-10-19 | 2008-05-02 | Genentech, Inc. | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases |
| NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| TWI419904B (zh) * | 2006-12-18 | 2013-12-21 | Genentech Inc | 拮抗劑抗-ｎｏｔｃｈ３抗體及其用於預防及治療ｎｏｔｃｈ３相關疾病之用途 |
| EP2120996A2 (en) * | 2006-12-20 | 2009-11-25 | Vasgene Therapeutics, Inc. | Methods for using and identifying modulators of delta-like 4 |
| EP2106439B1 (en) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| WO2008091222A1 (en) * | 2007-01-26 | 2008-07-31 | Bioinvent International Ab | Dll4 signaling inhibitors and uses thereof |
| GB0709333D0 (en) * | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
| PE20090321A1 (es) * | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
| AU2009235467A1 (en) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Single variable domains against the Notch pathways |
| NZ590127A (en) | 2008-07-08 | 2012-11-30 | Oncomed Pharm Inc | Notch1 receptor binding agents and methods of use thereof |
| US8834875B2 (en) | 2010-01-13 | 2014-09-16 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| US7544476B1 (en) * | 2008-07-11 | 2009-06-09 | Aveo Pharmaceuticals, Inc. | Identifying cancers sensitive to treatment with inhibitors of notch signaling |
| EP2344536A1 (en) * | 2008-09-19 | 2011-07-20 | MedImmune, LLC | Antibodies directed to dll4 and uses thereof |
| PE20120080A1 (es) * | 2008-10-01 | 2012-02-17 | Genentech Inc | Anticuerpos anti-notch2 y metodos de uso |
| DK2356270T3 (da) | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| EP2424567B1 (en) | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| TWI513465B (zh) * | 2009-06-25 | 2015-12-21 | Regeneron Pharma | 以ｄｌｌ４拮抗劑與化學治療劑治療癌症之方法 |
| SG178930A1 (en) | 2009-08-29 | 2012-04-27 | Abbott Lab | Therapeutic dll4 binding proteins |
| US20110172398A1 (en) | 2009-10-02 | 2011-07-14 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules for anti-angiogenesis therapy |
| UY32917A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moléculas de unión a dll-4 |
| ES2895226T3 (es) * | 2009-10-16 | 2022-02-18 | Mereo Biopharma 5 Inc | Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensivos |
| WO2011068840A1 (en) * | 2009-12-01 | 2011-06-09 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancers comprising k-ras mutations |
| JO3274B1 (ar) | 2009-12-24 | 2018-09-16 | Regeneron Pharma | أجسام مضادة بشرية للبروتين 4 المشابه لأجيوبيوتين البشري |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| JO3183B1 (ar) | 2010-01-29 | 2018-03-08 | Regeneron Pharma | طرق لمعالجة أمراض المناعة الذاتية مضادات dll4 |
| RU2605928C2 (ru) | 2010-03-02 | 2016-12-27 | Эббви Инк. | Терапевтические dll4-связывающие белки |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| PT2758073T (pt) | 2011-09-23 | 2019-02-01 | Oncomed Pharm Inc | Agentes de ligação a vegf/dll4 e utilizações dos mesmos |
| CA2883807A1 (en) | 2012-09-28 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents |
| EP2914961A4 (en) | 2012-10-31 | 2016-04-20 | Oncomed Pharm Inc | METHODS AND MONITORING A TREATMENT BY AN ANTAGONIST OF DLL4 |
| AR093445A1 (es) | 2012-11-14 | 2015-06-10 | Regeneron Pharma | Metodos para tratar el cancer de ovario con antagonistas de dll4 |
| AU2015338974B2 (en) | 2014-10-31 | 2021-08-26 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| EA202091786A1 (ru) | 2018-01-26 | 2020-10-20 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Способы и композиции для лечения ангиогенных расстройств с применением агентов против фрэс |
| KR20220104756A (ko) | 2019-11-25 | 2022-07-26 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구내 신생혈관형성을 위한 장기지속형 vegf 억제제 |
| WO2023063842A1 (ru) * | 2021-10-12 | 2023-04-20 | Общество с ограниченной ответственностью "Пальмира Биофарма" | Нуклеотидная последовательность, кодирующая слитый белок |
| WO2024130165A1 (en) | 2022-12-16 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Angptl3 inhibitors for triglyceride reduction in multifactorial chylomicronemia syndrome |
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| US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
| DK1325932T5 (da) † | 1997-04-07 | 2005-10-03 | Genentech Inc | Anti-VEGF antistoffer |
| DE69837601T2 (de) * | 1997-05-14 | 2007-12-27 | Asahi Kasei Kabushiki Kaisha | Neuer hemmer der differentierung |
| CA2372053C (en) † | 1999-04-28 | 2008-09-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| HU230159B1 (hu) † | 1999-06-08 | 2015-09-28 | Regeneron Pharmaceuticals, Inc. | VEGF receptor kimérák alkalmazása vaszkuláris permeabilitással jellemzett szembetegség kezelésére |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| WO2003042246A2 (en) * | 2001-11-14 | 2003-05-22 | Lorantis Limited | Inhibitors of the notch signalling pathway for use in the treatment of cancer |
| CA2469204A1 (en) * | 2001-12-07 | 2003-06-19 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
| AU2003267563A1 (en) | 2002-09-10 | 2004-04-30 | Lorantis Limited | Pharmaceutical composition and medical treatments comprising notch ligand proteins |
| US20060134121A1 (en) | 2004-10-29 | 2006-06-22 | Gavin Thurston | DII4 antagonists, assays, and therapeutic methods thereof |
| WO2007028110A2 (en) | 2005-09-01 | 2007-03-08 | Vasgene Therapeutics, Inc. | Methods for using and identifying modulators of delta-like 4 |
| AU2007319672B2 (en) * | 2006-06-06 | 2011-06-30 | Genentech, Inc. | Anti-DLL4 antibodies and methods using same |
| US20080014196A1 (en) * | 2006-06-06 | 2008-01-17 | Genentech, Inc. | Compositions and methods for modulating vascular development |
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- 2006-12-15 US US11/639,894 patent/US20080107648A1/en not_active Abandoned
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- 2006-12-15 DK DK06848586.1T patent/DK1962895T3/da active
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- 2006-12-15 PT PT68485861T patent/PT1962895E/pt unknown
- 2006-12-15 NZ NZ568739A patent/NZ568739A/en not_active IP Right Cessation
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2008
- 2008-05-29 IL IL191810A patent/IL191810A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2630839A1 (en) | 2007-06-21 |
| NZ568739A (en) | 2010-09-30 |
| EP1962895A2 (en) | 2008-09-03 |
| WO2007070671A3 (en) | 2008-01-10 |
| US20080107648A1 (en) | 2008-05-08 |
| IL191810A0 (en) | 2009-02-11 |
| AU2006326417A1 (en) | 2007-06-21 |
| DK1962895T3 (da) | 2013-03-04 |
| JP2009519944A (ja) | 2009-05-21 |
| WO2007070671A2 (en) | 2007-06-21 |
| IL191810A (en) | 2017-11-30 |
| ES2400666T3 (es) | 2013-04-11 |
| PL1962895T3 (pl) | 2013-06-28 |
| EP1962895B2 (en) | 2016-01-20 |
| PT1962895E (pt) | 2013-03-28 |
| AU2006326417B2 (en) | 2012-05-24 |
| JP5489465B2 (ja) | 2014-05-14 |
| ES2400666T5 (es) | 2016-03-10 |
| EP1962895B1 (en) | 2013-02-13 |
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