CA2629714A1 - Administration of an mtor inhibitor to treat patients with cancer - Google Patents
Administration of an mtor inhibitor to treat patients with cancer Download PDFInfo
- Publication number
- CA2629714A1 CA2629714A1 CA002629714A CA2629714A CA2629714A1 CA 2629714 A1 CA2629714 A1 CA 2629714A1 CA 002629714 A CA002629714 A CA 002629714A CA 2629714 A CA2629714 A CA 2629714A CA 2629714 A1 CA2629714 A1 CA 2629714A1
- Authority
- CA
- Canada
- Prior art keywords
- mtor inhibitor
- cancer
- day
- patient
- mtor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| US20120064143A1 (en) | 2008-11-11 | 2012-03-15 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
| WO2010120599A2 (en) | 2009-04-16 | 2010-10-21 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
| US8911766B2 (en) * | 2009-06-26 | 2014-12-16 | Abbott Cardiovascular Systems Inc. | Drug delivery compositions including nanoshells for triggered drug release |
| WO2011024168A2 (en) * | 2009-08-26 | 2011-03-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd | Sustained release delivery systems for the prevention and treatment of head and neck cancers |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US20130035336A1 (en) * | 2010-04-13 | 2013-02-07 | Novartis Ag | Combination comprising a cyclin dependent kinase 4 or cyclin dependent kinase (cdk4/6) inhibitor for treating cancer |
| JP2012061053A (ja) | 2010-09-14 | 2012-03-29 | Yuuki Kitaoka | 投薬装置、投薬装置の作動方法及び投薬方法 |
| AR083267A1 (es) * | 2010-10-04 | 2013-02-13 | Novartis Ag | Combinaciones farmaceuticas |
| BR112013027486A2 (pt) * | 2011-04-25 | 2017-02-14 | Novartis Ag | combinação de um inibidor de fosfatidilinositol-3-cinase (pi3k) e um inibidor de mtor |
| BR112014013332B1 (pt) * | 2011-12-02 | 2022-09-06 | Signal Pharmaceuticals, Llc | Composições farmacêuticas de 7-(6-(2-hidroxi-propan-2-il)piridin-3-il)-1-((trans)-4- metoxicicloexil)-3,4-diidropirazino [2,3-b]pirazin-2(1h)-ona, uma forma sólida dessa e métodos de seu uso |
| JP6381523B2 (ja) | 2012-05-16 | 2018-08-29 | ノバルティス アーゲー | Ｐｉ−３キナーゼ阻害剤の投与レジメン |
| US9757432B2 (en) | 2012-11-14 | 2017-09-12 | Ohio State Innovation Foundation | Materials and methods useful for treating glioblastorna |
| US20160030401A1 (en) | 2013-03-13 | 2016-02-04 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors for prevention of intestinal polyp growth and cancer |
| CN104721158B (zh) * | 2013-12-24 | 2018-01-30 | 正大天晴药业集团股份有限公司 | 一种稳定的依维莫司片剂 |
| DK3089737T3 (da) | 2013-12-31 | 2021-12-13 | Rapamycin Holdings Llc | Orale rapamycin-nanopartikelpræparater og anvendelse. |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CN106166296A (zh) * | 2016-07-01 | 2016-11-30 | 江南大学 | 一种辅助雷帕霉素治疗多种肿瘤的药物组合物 |
| CN107714719A (zh) * | 2017-11-08 | 2018-02-23 | 上海市第妇婴保健院 | 雷帕霉素在制备治疗白细胞介素‑27低表达子宫内膜癌的药物中的应用 |
| CN115135322A (zh) * | 2020-02-21 | 2022-09-30 | 韩国高等科学技术学院 | 包含哺乳动物雷帕霉素靶蛋白信号传导抑制剂作为有效成分的用于预防或治疗癌症的药物组合物 |
| CN114767867A (zh) * | 2021-12-22 | 2022-07-22 | 中山大学孙逸仙纪念医院 | 一种用于治疗cdk4/6抑制剂耐药后的乳腺癌的药物组合物及其应用 |
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| IL102414A (en) | 1991-07-25 | 1996-08-04 | Univ Louisville Res Found | Medicinal preparations for the treatment of ocular inflammation, containing rapamycin |
| US5286730A (en) | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
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-
2006
- 2006-11-14 CN CN2012100014166A patent/CN102579467A/zh active Pending
- 2006-11-14 CN CN2006800510347A patent/CN101360495B/zh not_active Expired - Fee Related
- 2006-11-14 EA EA200801309A patent/EA015922B1/ru not_active IP Right Cessation
- 2006-11-14 CA CA002629714A patent/CA2629714A1/en not_active Abandoned
- 2006-11-14 JP JP2008540275A patent/JP5709354B2/ja not_active Expired - Fee Related
- 2006-11-14 EP EP13179744.1A patent/EP2662082A1/en not_active Withdrawn
- 2006-11-14 EP EP06844354A patent/EP1962839A4/en not_active Withdrawn
- 2006-11-14 WO PCT/US2006/044146 patent/WO2007059106A2/en not_active Ceased
- 2006-11-14 AU AU2006315512A patent/AU2006315512B2/en not_active Ceased
- 2006-11-14 US US11/598,850 patent/US20070185150A1/en not_active Abandoned
-
2008
- 2008-05-12 IL IL191356A patent/IL191356A0/en unknown
-
2013
- 2013-09-13 JP JP2013191029A patent/JP2014012721A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006315512B2 (en) | 2012-11-01 |
| JP2014012721A (ja) | 2014-01-23 |
| CN101360495B (zh) | 2012-03-14 |
| WO2007059106A3 (en) | 2008-06-05 |
| EP2662082A1 (en) | 2013-11-13 |
| EP1962839A2 (en) | 2008-09-03 |
| IL191356A0 (en) | 2009-08-03 |
| EA015922B1 (ru) | 2011-12-30 |
| AU2006315512A1 (en) | 2007-05-24 |
| JP2009515901A (ja) | 2009-04-16 |
| CN101360495A (zh) | 2009-02-04 |
| EA200801309A1 (ru) | 2008-10-30 |
| JP5709354B2 (ja) | 2015-04-30 |
| CN102579467A (zh) | 2012-07-18 |
| US20070185150A1 (en) | 2007-08-09 |
| EP1962839A4 (en) | 2010-08-25 |
| WO2007059106A2 (en) | 2007-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150617 |