CA2625888C - Method of treating acute renal failure with thrombomodulin variant - Google Patents

Method of treating acute renal failure with thrombomodulin variant Download PDF

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Publication number
CA2625888C
CA2625888C CA2625888A CA2625888A CA2625888C CA 2625888 C CA2625888 C CA 2625888C CA 2625888 A CA2625888 A CA 2625888A CA 2625888 A CA2625888 A CA 2625888A CA 2625888 C CA2625888 C CA 2625888C
Authority
CA
Canada
Prior art keywords
stm
renal failure
acute
thrombomodulin
acute renal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2625888A
Other languages
English (en)
French (fr)
Other versions
CA2625888A1 (en
Inventor
Brian William Grinnell
Thurman Dwight Mckinney
Bruce A. Molitoris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp, Eli Lilly and Co filed Critical Indiana University Research and Technology Corp
Publication of CA2625888A1 publication Critical patent/CA2625888A1/en
Application granted granted Critical
Publication of CA2625888C publication Critical patent/CA2625888C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2625888A 2005-10-13 2006-10-12 Method of treating acute renal failure with thrombomodulin variant Expired - Fee Related CA2625888C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72637605P 2005-10-13 2005-10-13
US60/726,376 2005-10-13
PCT/US2006/040069 WO2007047430A2 (en) 2005-10-13 2006-10-12 Method of treating acute failure with thrombomodulin variant

Publications (2)

Publication Number Publication Date
CA2625888A1 CA2625888A1 (en) 2007-04-26
CA2625888C true CA2625888C (en) 2015-09-22

Family

ID=37670944

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2625888A Expired - Fee Related CA2625888C (en) 2005-10-13 2006-10-12 Method of treating acute renal failure with thrombomodulin variant

Country Status (13)

Country Link
US (1) US20080255047A1 (enExample)
EP (1) EP1948216B1 (enExample)
JP (1) JP5405829B2 (enExample)
AT (1) ATE503489T1 (enExample)
CA (1) CA2625888C (enExample)
CY (1) CY1112438T1 (enExample)
DE (1) DE602006021048D1 (enExample)
DK (1) DK1948216T3 (enExample)
ES (1) ES2360610T3 (enExample)
PL (1) PL1948216T3 (enExample)
PT (1) PT1948216E (enExample)
SI (1) SI1948216T1 (enExample)
WO (1) WO2007047430A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076298B2 (en) 2006-12-12 2011-12-13 Eli Lilly And Company Treating acute renal failure with soluble thrombomodulin variants
BRPI0922033A2 (pt) * 2008-11-12 2015-12-15 Lilly Co Eli composições e métodos de uso de variantes de trombomodulina

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2022713A1 (en) * 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
CA2129370A1 (en) * 1992-02-05 1993-08-19 David Richard Light Protease-resistant thrombomodulin analogs
ATE249234T1 (de) * 1993-12-17 2003-09-15 Mochida Pharm Co Ltd Lösliches thrombomodulin enthaltende zubereitung
US20050106124A1 (en) * 2003-02-25 2005-05-19 Sehgal Lakshman R. Therapeutic applications of thrombomodulin gene via viral and non-viral vectors

Also Published As

Publication number Publication date
EP1948216A2 (en) 2008-07-30
WO2007047430A3 (en) 2007-05-24
ATE503489T1 (de) 2011-04-15
WO2007047430A2 (en) 2007-04-26
DE602006021048D1 (de) 2011-05-12
CA2625888A1 (en) 2007-04-26
WO2007047430A8 (en) 2008-04-10
EP1948216B1 (en) 2011-03-30
PL1948216T3 (pl) 2011-10-31
JP5405829B2 (ja) 2014-02-05
JP2009511597A (ja) 2009-03-19
ES2360610T3 (es) 2011-06-07
CY1112438T1 (el) 2015-12-09
DK1948216T3 (da) 2011-06-06
PT1948216E (pt) 2011-05-06
US20080255047A1 (en) 2008-10-16
SI1948216T1 (sl) 2011-07-29

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20181012