CA2609347C - Use of chalcones for the treatment of viral disorders - Google Patents
Use of chalcones for the treatment of viral disorders Download PDFInfo
- Publication number
- CA2609347C CA2609347C CA2609347A CA2609347A CA2609347C CA 2609347 C CA2609347 C CA 2609347C CA 2609347 A CA2609347 A CA 2609347A CA 2609347 A CA2609347 A CA 2609347A CA 2609347 C CA2609347 C CA 2609347C
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- Prior art keywords
- hydrochloride
- compound
- agents
- dihydroxy
- stereoisomer
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
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- 239000011343 solid material Substances 0.000 description 1
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- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
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- 125000004024 talosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
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- 239000010677 tea tree oil Substances 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
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- 239000012085 test solution Substances 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960004880 tolnaftate Drugs 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- 210000000427 trigeminal ganglion Anatomy 0.000 description 1
- COXJMKGEQAWXNP-UHFFFAOYSA-N tris(14-methylpentadecyl) 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CC(C)CCCCCCCCCCCCCOC(=O)CC(O)(C(=O)OCCCCCCCCCCCCCC(C)C)CC(=O)OCCCCCCCCCCCCCC(C)C COXJMKGEQAWXNP-UHFFFAOYSA-N 0.000 description 1
- UPCXAARSWVHVLY-UHFFFAOYSA-N tris(2-hydroxyethyl)azanium;acetate Chemical compound CC(O)=O.OCCN(CCO)CCO UPCXAARSWVHVLY-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
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- 239000010497 wheat germ oil Substances 0.000 description 1
- 229940072358 xylocaine Drugs 0.000 description 1
- 125000000969 xylosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)CO1)* 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/137,198 US20060270614A1 (en) | 2005-05-24 | 2005-05-24 | Use of chalcones for the treatment of viral disorders |
| US11/137,198 | 2005-05-24 | ||
| PCT/US2006/019626 WO2006127539A1 (en) | 2005-05-24 | 2006-05-19 | Use of chalcones for the treatment of viral disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2609347A1 CA2609347A1 (en) | 2006-11-30 |
| CA2609347C true CA2609347C (en) | 2013-12-31 |
Family
ID=36942429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2609347A Expired - Fee Related CA2609347C (en) | 2005-05-24 | 2006-05-19 | Use of chalcones for the treatment of viral disorders |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060270614A1 (https=) |
| EP (1) | EP1888174B1 (https=) |
| JP (1) | JP5179352B2 (https=) |
| CN (1) | CN101448551A (https=) |
| AU (1) | AU2006251668B2 (https=) |
| BR (1) | BRPI0610211A2 (https=) |
| CA (1) | CA2609347C (https=) |
| WO (1) | WO2006127539A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080221029A1 (en) * | 2002-10-31 | 2008-09-11 | Regents Of The University Of Colorado | Methods for treatment of thiol-containing compound deficient conditions |
| CN103755541B (zh) * | 2014-02-19 | 2015-09-02 | 厦门大学 | 一类查尔酮衍生物及其制备方法和用途 |
| KR101731159B1 (ko) | 2015-02-04 | 2017-04-28 | 계명대학교 산학협력단 | 2',4'-디하이드록시칼콘 화합물을 유효성분으로 포함하는 항진균용 조성물 |
| CN106497891B (zh) * | 2017-01-03 | 2019-11-08 | 上海青赛生物科技有限公司 | 一种流感病毒疫苗的生产方法 |
| EP4125981A4 (en) | 2020-04-02 | 2023-12-27 | Mollick, Peter J. | THERAPEUTIC TREATMENT OF CORONAVIRUS DISEASE COVID-19 |
| US20230338362A1 (en) * | 2020-09-17 | 2023-10-26 | Iaterion, Inc. | Methods and compositions for treating viral infections |
| TWI896916B (zh) * | 2022-12-02 | 2025-09-11 | 豐苗生物科技股份有限公司 | 柑橘屬萃取物、化合物、及其用於抑制新型冠狀病毒的用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4279930A (en) * | 1978-10-10 | 1981-07-21 | The Upjohn Company | Process for treating inflammation |
| CA1137082A (en) * | 1979-05-23 | 1982-12-07 | Isao Umeda | Substituted acetophenones and process therefor |
| JP2913706B2 (ja) * | 1988-11-21 | 1999-06-28 | 大日本インキ化学工業株式会社 | カルコン誘導体及びその製造方法 |
| EP0996432A2 (en) * | 1997-06-26 | 2000-05-03 | Statens Seruminstitut | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones |
| US20030065039A1 (en) * | 1997-06-26 | 2003-04-03 | Statens Serum Institute | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones |
| BR9908870A (pt) * | 1998-03-16 | 2000-11-21 | Procter & Gamble | Processos para regularizarem a aparência da pele |
| AU735384B2 (en) * | 1998-03-16 | 2001-07-05 | Procter & Gamble Company, The | Compositions for regulating skin appearance |
| US7306815B2 (en) * | 2000-08-31 | 2007-12-11 | Phenolics, Llc | Compositions enriched in phenolic compounds and methods for producing the same |
| US7083813B2 (en) * | 2002-11-06 | 2006-08-01 | The Quigley Corporation | Methods for the treatment of peripheral neural and vascular ailments |
| US20050069563A1 (en) * | 2003-09-26 | 2005-03-31 | Garner Michael D. | Method for treating herpes simplex virus and fungal pimples with antifungal medication |
| CN1964627B (zh) * | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| US20080166304A1 (en) * | 2004-09-17 | 2008-07-10 | The General Hospital Corpoartion | Inactivation of Microorganisms With Multidrug Resistance Inhibitors and Phenothiaziniums |
-
2005
- 2005-05-24 US US11/137,198 patent/US20060270614A1/en not_active Abandoned
-
2006
- 2006-05-19 CN CNA2006800257917A patent/CN101448551A/zh active Pending
- 2006-05-19 JP JP2008513570A patent/JP5179352B2/ja not_active Expired - Fee Related
- 2006-05-19 EP EP06760236A patent/EP1888174B1/en not_active Not-in-force
- 2006-05-19 BR BRPI0610211-5A patent/BRPI0610211A2/pt not_active IP Right Cessation
- 2006-05-19 AU AU2006251668A patent/AU2006251668B2/en not_active Ceased
- 2006-05-19 CA CA2609347A patent/CA2609347C/en not_active Expired - Fee Related
- 2006-05-19 WO PCT/US2006/019626 patent/WO2006127539A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0610211A2 (pt) | 2010-11-09 |
| EP1888174B1 (en) | 2012-02-22 |
| WO2006127539A1 (en) | 2006-11-30 |
| EP1888174A1 (en) | 2008-02-20 |
| US20060270614A1 (en) | 2006-11-30 |
| CA2609347A1 (en) | 2006-11-30 |
| JP5179352B2 (ja) | 2013-04-10 |
| AU2006251668B2 (en) | 2012-02-02 |
| CN101448551A (zh) | 2009-06-03 |
| JP2008542275A (ja) | 2008-11-27 |
| AU2006251668A1 (en) | 2006-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170519 |