CA2608643A1 - Gene-based algorithmic cancer prognosis - Google Patents

Gene-based algorithmic cancer prognosis Download PDF

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Publication number
CA2608643A1
CA2608643A1 CA002608643A CA2608643A CA2608643A1 CA 2608643 A1 CA2608643 A1 CA 2608643A1 CA 002608643 A CA002608643 A CA 002608643A CA 2608643 A CA2608643 A CA 2608643A CA 2608643 A1 CA2608643 A1 CA 2608643A1
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Canada
Prior art keywords
cancer
gene
genes
tumor sample
grade
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Abandoned
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CA002608643A
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English (en)
French (fr)
Inventor
Christos Sotiriou
Mauro Delorenzi
Martine Piccart
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Universite Libre de Bruxelles ULB
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Individual
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Publication of CA2608643A1 publication Critical patent/CA2608643A1/en
Abandoned legal-status Critical Current

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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Theoretical Computer Science (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
CA002608643A 2005-05-13 2006-05-15 Gene-based algorithmic cancer prognosis Abandoned CA2608643A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68054305P 2005-05-13 2005-05-13
US60/680,543 2005-05-13
EP05447274 2005-12-07
EP05447274.1 2005-12-07
PCT/BE2006/000051 WO2006119593A1 (en) 2005-05-13 2006-05-15 Gene-based algorithmic cancer prognosis

Publications (1)

Publication Number Publication Date
CA2608643A1 true CA2608643A1 (en) 2006-11-16

Family

ID=36061623

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002608643A Abandoned CA2608643A1 (en) 2005-05-13 2006-05-15 Gene-based algorithmic cancer prognosis

Country Status (6)

Country Link
EP (1) EP1880335A1 (zh)
JP (1) JP2008539737A (zh)
CN (1) CN101356532B (zh)
AU (1) AU2006246241A1 (zh)
CA (1) CA2608643A1 (zh)
WO (1) WO2006119593A1 (zh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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US20030198972A1 (en) 2001-12-21 2003-10-23 Erlander Mark G. Grading of breast cancer
US9856533B2 (en) 2003-09-19 2018-01-02 Biotheranostics, Inc. Predicting breast cancer treatment outcome
US20080275652A1 (en) * 2005-05-13 2008-11-06 Universite Libre De Bruxelles Gene-based algorithmic cancer prognosis
US20080286273A1 (en) * 2007-05-02 2008-11-20 Siemens Medical Solutions Usa, Inc. Knowledge-Based Proliferation Signatures and Methods of Use
US7960114B2 (en) 2007-05-02 2011-06-14 Siemens Medical Solutions Usa, Inc. Gene signature of early hypoxia to predict patient survival
CN102395682B (zh) * 2007-09-06 2015-09-30 生物治疗诊断股份有限公司 肿瘤分级和癌症预后
AU2008294687A1 (en) 2007-09-07 2009-03-12 Universite Libre De Bruxelles Methods and tools for prognosis of cancer in ER- patients
CA2695814A1 (en) * 2007-09-07 2009-04-23 Universite Libre De Bruxelles Methods and tools for prognosis of cancer in her2+ patients
WO2009103790A2 (en) 2008-02-21 2009-08-27 Universite Libre De Bruxelles Method and kit for the detection of genes associated with pik3ca mutation and involved in pi3k/akt pathway activation in the er-positive and her2-positive subtypes with clinical implications
JPWO2009113495A1 (ja) * 2008-03-12 2011-07-21 財団法人ヒューマンサイエンス振興財団 肝癌特異的発現遺伝子による肝癌の検査方法並びに肝癌の治療及び予防剤
ES2595410T3 (es) * 2009-01-07 2016-12-29 Myriad Genetics, Inc. Biomarcadores de cáncer
US20120041274A1 (en) 2010-01-07 2012-02-16 Myriad Genetics, Incorporated Cancer biomarkers
CA2782620A1 (en) * 2009-12-01 2011-06-09 Compendia Bioscience, Inc. Classification of cancers
BR112012019640A2 (pt) * 2010-02-05 2017-06-20 Translational Genomics Res Inst métodos e kits usados na classificação de carcinoma adrenocortical
KR101864855B1 (ko) * 2010-03-31 2018-07-13 지피돈 디아그노스틱스 게엠베하 내분비 치료 중 유방암 재발 예측 방법
EP2591126B1 (en) 2010-07-07 2020-12-30 Myriad Genetics, Inc. Gene signatures for cancer prognosis
WO2012030840A2 (en) 2010-08-30 2012-03-08 Myriad Genetics, Inc. Gene signatures for cancer diagnosis and prognosis
EP2648762B1 (en) 2010-12-09 2018-02-21 Biotheranostics, Inc. Post-treatment breast cancer prognosis
US20140228241A1 (en) 2011-07-28 2014-08-14 Sividon Diagnostics Gmbh Method for predicting the response to chemotherapy in a patient suffering from or at risk of developing recurrentbreast cancer
JP2013219629A (ja) 2012-04-10 2013-10-24 Sony Computer Entertainment Inc 情報処理装置および録画機器選択方法
US10408846B2 (en) * 2012-05-15 2019-09-10 Novartis Ag Quantitative methods and kits for providing reproducible IHC4 scores
EP4190918A1 (en) 2012-11-16 2023-06-07 Myriad Genetics, Inc. Gene signatures for cancer prognosis
WO2014118333A1 (en) 2013-02-01 2014-08-07 Sividon Diagnostics Gmbh Method for predicting the benefit from inclusion of taxane in a chemotherapy regimen in patients with breast cancer
CN103205433B (zh) * 2013-04-03 2014-06-04 复旦大学附属肿瘤医院 用于肺癌预后的基因及其应用
KR101636995B1 (ko) * 2014-02-05 2016-07-21 연세대학교 산학협력단 도메인 특이적인 계통발생학적 프로파일 유사성을 이용한 유전자 네트워크의 개선 방법
CA2947624A1 (en) 2014-05-13 2015-11-19 Myriad Genetics, Inc. Gene signatures for cancer prognosis
DK3303618T3 (da) * 2015-05-29 2019-12-16 Koninklijke Philips Nv Fremgangsmåder til prognose af prostatacancer
CN106442991B (zh) * 2015-08-06 2018-07-27 中国人民解放军军事医学科学院生物医学分析中心 用于预测肺腺癌患者预后及判断辅助化疗获益的系统
MX2018005867A (es) 2015-11-13 2018-09-21 Biotheranostics Inc Integracion de las caracteristicas tumorales con el indice de cancer de mama.
WO2017189976A1 (en) 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Targeted measure of transcriptional activity related to hormone receptors
CN107326065B (zh) * 2016-04-29 2022-07-29 博尔诚(北京)科技有限公司 一种基因标识物的筛选方法及其应用
WO2019051266A2 (en) 2017-09-08 2019-03-14 Myriad Genetics, Inc. METHOD OF USING BIOMARKERS AND CLINICAL VARIABLES TO PREDICT THE INTEREST OF CHEMOTHERAPY
CN108648826B (zh) * 2018-05-09 2022-04-15 中国科学院昆明动物研究所 一种基于多基因表达特征谱的胰腺癌个性化预后评估方法
CN108424970B (zh) * 2018-06-13 2021-04-13 深圳市颐康生物科技有限公司 用于检测癌症复发风险的生物标志物及检测方法
CN112760384B (zh) * 2021-04-06 2021-06-25 臻和(北京)生物科技有限公司 一种胰腺癌预后判定方法及装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198972A1 (en) * 2001-12-21 2003-10-23 Erlander Mark G. Grading of breast cancer
GB0323225D0 (en) * 2003-10-03 2003-11-05 Ncc Technology Ventures Pte Lt Materials and methods relating to breast cancer classification

Also Published As

Publication number Publication date
AU2006246241A1 (en) 2006-11-16
JP2008539737A (ja) 2008-11-20
EP1880335A1 (en) 2008-01-23
CN101356532B (zh) 2012-08-01
CN101356532A (zh) 2009-01-28
WO2006119593A1 (en) 2006-11-16

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Effective date: 20140210