CA2608643A1 - Pronostic algorithmique du cancer base sur les genes gene-based algorithmic cancer prognosis - Google Patents

Pronostic algorithmique du cancer base sur les genes gene-based algorithmic cancer prognosis Download PDF

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Publication number
CA2608643A1
CA2608643A1 CA002608643A CA2608643A CA2608643A1 CA 2608643 A1 CA2608643 A1 CA 2608643A1 CA 002608643 A CA002608643 A CA 002608643A CA 2608643 A CA2608643 A CA 2608643A CA 2608643 A1 CA2608643 A1 CA 2608643A1
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Prior art keywords
cancer
gene
genes
tumor sample
grade
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Abandoned
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CA002608643A
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English (en)
Inventor
Christos Sotiriou
Mauro Delorenzi
Martine Piccart
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Universite Libre de Bruxelles ULB
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Theoretical Computer Science (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
CA002608643A 2005-05-13 2006-05-15 Pronostic algorithmique du cancer base sur les genes gene-based algorithmic cancer prognosis Abandoned CA2608643A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68054305P 2005-05-13 2005-05-13
US60/680,543 2005-05-13
EP05447274.1 2005-12-07
EP05447274 2005-12-07
PCT/BE2006/000051 WO2006119593A1 (fr) 2005-05-13 2006-05-15 Pronostic algorithmique du cancer base sur les genes gene-based algorithmic cancer prognosis

Publications (1)

Publication Number Publication Date
CA2608643A1 true CA2608643A1 (fr) 2006-11-16

Family

ID=36061623

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002608643A Abandoned CA2608643A1 (fr) 2005-05-13 2006-05-15 Pronostic algorithmique du cancer base sur les genes gene-based algorithmic cancer prognosis

Country Status (6)

Country Link
EP (1) EP1880335A1 (fr)
JP (1) JP2008539737A (fr)
CN (1) CN101356532B (fr)
AU (1) AU2006246241A1 (fr)
CA (1) CA2608643A1 (fr)
WO (1) WO2006119593A1 (fr)

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US20030198972A1 (en) 2001-12-21 2003-10-23 Erlander Mark G. Grading of breast cancer
US9856533B2 (en) 2003-09-19 2018-01-02 Biotheranostics, Inc. Predicting breast cancer treatment outcome
US20080275652A1 (en) * 2005-05-13 2008-11-06 Universite Libre De Bruxelles Gene-based algorithmic cancer prognosis
US20080286273A1 (en) * 2007-05-02 2008-11-20 Siemens Medical Solutions Usa, Inc. Knowledge-Based Proliferation Signatures and Methods of Use
US7960114B2 (en) 2007-05-02 2011-06-14 Siemens Medical Solutions Usa, Inc. Gene signature of early hypoxia to predict patient survival
CN102395682B (zh) * 2007-09-06 2015-09-30 生物治疗诊断股份有限公司 肿瘤分级和癌症预后
WO2009049966A2 (fr) * 2007-09-07 2009-04-23 Universite Libre De Bruxelles Procédés et outils de diagnostic de cancer chez des patients her2+
CA2696947A1 (fr) 2007-09-07 2009-03-12 Universite Libre De Bruxelles Procedes et outils de diagnostic de cancer chez des patients er-
WO2009103790A2 (fr) 2008-02-21 2009-08-27 Universite Libre De Bruxelles Procédé et trousse de détection des gènes associés à la mutation du pik3ca et impliqués dans l’activation de la voie pi3k/akt dans les sous-types er-positifs et her2-positifs avec des implications cliniques.
JPWO2009113495A1 (ja) * 2008-03-12 2011-07-21 財団法人ヒューマンサイエンス振興財団 肝癌特異的発現遺伝子による肝癌の検査方法並びに肝癌の治療及び予防剤
US20120041274A1 (en) 2010-01-07 2012-02-16 Myriad Genetics, Incorporated Cancer biomarkers
CA2749103A1 (fr) * 2009-01-07 2010-07-15 Steve Stone Biomarqueurs de cancer
CN102858999A (zh) * 2009-12-01 2013-01-02 简要生物科学有限公司 癌症的分类
EP2531856A4 (fr) * 2010-02-05 2013-07-10 Translational Genomics Res Inst Procédés et trousses utilisés pour classer un carcinome adrénocortical
BR122020016370B1 (pt) * 2010-03-31 2021-05-11 Sividon Diagnostics Gmbh métodos para predizer um resultado de câncer de mama em um tumor de mama positivo para receptor de estrogênio e negativo para her2 de um paciente com câncer de mama
US20120053253A1 (en) 2010-07-07 2012-03-01 Myriad Genetics, Incorporated Gene signatures for cancer prognosis
WO2012030840A2 (fr) 2010-08-30 2012-03-08 Myriad Genetics, Inc. Signatures génétiques pour le diagnostic et le pronostic du cancer
WO2012079059A2 (fr) 2010-12-09 2012-06-14 Biotheranostics, Inc. Pronostic du cancer du sein après traitement
WO2013014296A1 (fr) 2011-07-28 2013-01-31 Sividon Diagnostics Gmbh Méthode de prédiction de la réponse à une chimiothérapie chez un patient souffrant d'un cancer du sein récidivant ou susceptible de le développer
JP2013219629A (ja) 2012-04-10 2013-10-24 Sony Computer Entertainment Inc 情報処理装置および録画機器選択方法
US10408846B2 (en) * 2012-05-15 2019-09-10 Novartis Ag Quantitative methods and kits for providing reproducible IHC4 scores
EP2920322B1 (fr) 2012-11-16 2023-01-11 Myriad Genetics, Inc. Signatures génétiques utilisées en vue du pronostic d'un cancer
DK2951317T3 (en) 2013-02-01 2018-01-15 Sividon Diagnostics Gmbh PROCEDURE FOR PREDICTING THE BENEFIT OF INCLUSING TAXAN IN A CHEMOTHERAPY PLAN FOR BREAST CANCER PATIENTS
CN103205433B (zh) * 2013-04-03 2014-06-04 复旦大学附属肿瘤医院 用于肺癌预后的基因及其应用
KR101636995B1 (ko) * 2014-02-05 2016-07-21 연세대학교 산학협력단 도메인 특이적인 계통발생학적 프로파일 유사성을 이용한 유전자 네트워크의 개선 방법
CA2947624A1 (fr) 2014-05-13 2015-11-19 Myriad Genetics, Inc. Signatures genetiques utilisees en vue du pronostic d'un cancer
WO2016193109A1 (fr) * 2015-05-29 2016-12-08 Koninklijke Philips N.V. Procédés pour le pronostic du cancer de la prostate
CN106442991B (zh) * 2015-08-06 2018-07-27 中国人民解放军军事医学科学院生物医学分析中心 用于预测肺腺癌患者预后及判断辅助化疗获益的系统
US11530448B2 (en) 2015-11-13 2022-12-20 Biotheranostics, Inc. Integration of tumor characteristics with breast cancer index
BR112018072286A2 (pt) * 2016-04-29 2019-02-12 Yale University medida direcionada de atividade transcricional relacionada a receptores de hormônios
CN107326065B (zh) * 2016-04-29 2022-07-29 博尔诚(北京)科技有限公司 一种基因标识物的筛选方法及其应用
CA3075265A1 (fr) 2017-09-08 2019-03-14 Myriad Genetics, Inc. Procede d'utilisation de biomarqueurs et de variables cliniques pour predire l'interet d'une chimiotherapie
CN108648826B (zh) * 2018-05-09 2022-04-15 中国科学院昆明动物研究所 一种基于多基因表达特征谱的胰腺癌个性化预后评估方法
CN112941184A (zh) * 2018-06-13 2021-06-11 深圳市颐康生物科技有限公司 一种用于检测癌症复发风险的生物标志物
CN112760384B (zh) * 2021-04-06 2021-06-25 臻和(北京)生物科技有限公司 一种胰腺癌预后判定方法及装置

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198972A1 (en) * 2001-12-21 2003-10-23 Erlander Mark G. Grading of breast cancer
GB0323225D0 (en) * 2003-10-03 2003-11-05 Ncc Technology Ventures Pte Lt Materials and methods relating to breast cancer classification

Also Published As

Publication number Publication date
JP2008539737A (ja) 2008-11-20
CN101356532A (zh) 2009-01-28
EP1880335A1 (fr) 2008-01-23
WO2006119593A1 (fr) 2006-11-16
CN101356532B (zh) 2012-08-01
AU2006246241A1 (en) 2006-11-16

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Effective date: 20140210