CA2601380A1 - Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases - Google Patents
Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases Download PDFInfo
- Publication number
- CA2601380A1 CA2601380A1 CA002601380A CA2601380A CA2601380A1 CA 2601380 A1 CA2601380 A1 CA 2601380A1 CA 002601380 A CA002601380 A CA 002601380A CA 2601380 A CA2601380 A CA 2601380A CA 2601380 A1 CA2601380 A1 CA 2601380A1
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- Prior art keywords
- compound
- optionally substituted
- alkyl
- mmol
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- UORVCLMRJXCDCP-UHFFFAOYSA-N propynoic acid Chemical class OC(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-N 0.000 description 1
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- 125000004941 pyridazin-5-yl group Chemical group N1=NC=CC(=C1)* 0.000 description 1
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- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
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- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
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- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical class OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 1
- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
- 125000004426 substituted alkynyl group Chemical group 0.000 description 1
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- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
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- 239000007916 tablet composition Substances 0.000 description 1
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- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64555205P | 2005-01-20 | 2005-01-20 | |
| US60/645,552 | 2005-01-20 | ||
| PCT/US2006/001747 WO2006078724A2 (en) | 2005-01-20 | 2006-01-19 | Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2601380A1 true CA2601380A1 (en) | 2006-07-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002601380A Abandoned CA2601380A1 (en) | 2005-01-20 | 2006-01-19 | Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7553842B2 (enExample) |
| EP (1) | EP1838316A4 (enExample) |
| JP (1) | JP2008528491A (enExample) |
| AU (1) | AU2006206525A1 (enExample) |
| CA (1) | CA2601380A1 (enExample) |
| MX (1) | MX2007008662A (enExample) |
| TW (1) | TW200637552A (enExample) |
| WO (1) | WO2006078724A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0904540D0 (en) * | 2009-03-17 | 2009-04-29 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917817D0 (en) * | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917816D0 (en) * | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| IT1401451B1 (it) * | 2010-06-10 | 2013-07-26 | Chemi Spa | Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo. |
| WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
| AU2017238246B2 (en) * | 2016-03-24 | 2021-04-01 | The Administrators Of The Tulane Educational Fund | Conjugates of tacrolimus, their compositions, and their uses |
| RU2019117548A (ru) * | 2016-11-10 | 2020-12-10 | Новартис Аг | Усилители вмр |
| CN108148032B (zh) * | 2018-03-01 | 2019-12-13 | 北京海步医药科技股份有限公司 | 一种3,4-二氢-2h-1-苯并吡喃-2-羧酸类化合物的制备方法及其应用 |
| KR20210129058A (ko) * | 2019-01-23 | 2021-10-27 | 더 존스 홉킨스 유니버시티 | 비-면역억제성 fk506 유사체 및 이의 용도 |
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| GB2245891A (en) | 1990-07-09 | 1992-01-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
| US5565560A (en) | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
| US5563172A (en) * | 1991-09-05 | 1996-10-08 | Abbott Laboratories | Macrocyclic amide and urea immunomodulators |
| US5457111A (en) * | 1991-09-05 | 1995-10-10 | Abbott Laboratories | Macrocyclic immunomodulators |
| US5252732A (en) * | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
| US5284877A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkyl and alkenyl macrolides having immunosuppressive activity |
| US5457194A (en) * | 1993-03-17 | 1995-10-10 | Abbott Laboratories | Substituted aliphatic amine-containing macrocyclic immunomodulators |
| JPH08507788A (ja) * | 1993-03-17 | 1996-08-20 | アボツト・ラボラトリーズ | 置換脂環式アミン含有大環状免疫調節剤 |
| EP0689545A4 (en) * | 1993-03-17 | 1996-04-24 | Abbott Lab | IMMUNOREGULATORS WITH MACROCYCLIC AMIDE AND UREA |
| WO1994021634A1 (en) * | 1993-03-17 | 1994-09-29 | Abbott Laboratories | Substituted alicyclic-aliphatic amine-containing macrocyclic immunomodulators |
| US6093615A (en) * | 1994-08-15 | 2000-07-25 | Micron Technology, Inc. | Method of fabricating a contact structure having a composite barrier layer between a platinum layer and a polysilicon plug |
| DE19859467C2 (de) * | 1998-12-22 | 2002-11-28 | Steag Micro Tech Gmbh | Substrathalter |
| US6569867B2 (en) | 1999-10-01 | 2003-05-27 | Kosan Biosciences, Inc. | Polyketide derivatives |
-
2006
- 2006-01-19 WO PCT/US2006/001747 patent/WO2006078724A2/en not_active Ceased
- 2006-01-19 JP JP2007552233A patent/JP2008528491A/ja not_active Withdrawn
- 2006-01-19 CA CA002601380A patent/CA2601380A1/en not_active Abandoned
- 2006-01-19 MX MX2007008662A patent/MX2007008662A/es not_active Application Discontinuation
- 2006-01-19 EP EP06718768A patent/EP1838316A4/en not_active Withdrawn
- 2006-01-19 TW TW095102047A patent/TW200637552A/zh unknown
- 2006-01-19 US US11/334,858 patent/US7553842B2/en not_active Expired - Fee Related
- 2006-01-19 AU AU2006206525A patent/AU2006206525A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007008662A (es) | 2007-09-06 |
| TW200637552A (en) | 2006-11-01 |
| JP2008528491A (ja) | 2008-07-31 |
| AU2006206525A1 (en) | 2006-07-27 |
| WO2006078724A3 (en) | 2008-01-24 |
| US20060160838A1 (en) | 2006-07-20 |
| AU2006206525A2 (en) | 2006-07-27 |
| WO2006078724A2 (en) | 2006-07-27 |
| EP1838316A4 (en) | 2012-01-25 |
| US7553842B2 (en) | 2009-06-30 |
| EP1838316A2 (en) | 2007-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |