MX2007008662A

MX2007008662A - Analogos macrociclicos para el tratamiento de trastornos inmunorreguladores y enfermedades respiratorias.

Analogos macrociclicos para el tratamiento de trastornos inmunorreguladores y enfermedades respiratorias.

Info

Publication number: MX2007008662A
Authority: MX; Mexico
Prior art keywords: alkyl; optionally substituted; compound; mmol; compound according
Prior art date: 2005-01-20

Application number

MX2007008662A

Other languages

English (en)

Spanish (es)

Inventor

Kevin Hunter

Stephen Schlachter

John Gaudino

Laurence Burgess

Original Assignee

Array Biopharma Inc

Priority date

2005-01-20

Filing date

2006-01-19

Publication date

2007-09-06

2006-01-19 Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc

2007-09-06 Publication of MX2007008662A publication Critical patent/MX2007008662A/es

Links

238000011282 treatment Methods 0.000 title claims abstract description 53
230000004957 immunoregulator effect Effects 0.000 title abstract description 16
208000023504 respiratory system disease Diseases 0.000 title abstract description 8
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 59
208000035475 disorder Diseases 0.000 title description 23
150000001875 compounds Chemical class 0.000 claims abstract description 132
150000003839 salts Chemical class 0.000 claims abstract description 36
239000012453 solvate Substances 0.000 claims abstract description 21
-1 resolved enantiomers Chemical class 0.000 claims description 106
239000000203 mixture Substances 0.000 claims description 37
125000000217 alkyl group Chemical group 0.000 claims description 33
125000003118 aryl group Chemical group 0.000 claims description 24
125000000623 heterocyclic group Chemical group 0.000 claims description 23
125000003342 alkenyl group Chemical group 0.000 claims description 22
125000000304 alkynyl group Chemical group 0.000 claims description 21
125000004432 carbon atom Chemical group C* 0.000 claims description 21
239000003814 drug Substances 0.000 claims description 20
239000000460 chlorine Substances 0.000 claims description 17
229910052801 chlorine Inorganic materials 0.000 claims description 17
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 16
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 16
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 16
229910052794 bromium Inorganic materials 0.000 claims description 16
239000011737 fluorine Substances 0.000 claims description 16
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ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 12
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
239000001257 hydrogen Substances 0.000 claims description 12
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IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
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229910052757 nitrogen Inorganic materials 0.000 claims description 8
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229920006395 saturated elastomer Polymers 0.000 claims description 8
229910052717 sulfur Chemical group 0.000 claims description 8
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
239000001301 oxygen Chemical group 0.000 claims description 6
239000011593 sulfur Chemical group 0.000 claims description 6
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
125000005842 heteroatom Chemical group 0.000 claims description 5
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239000003937 drug carrier Substances 0.000 claims description 2
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125000001246 bromo group Chemical group Br* 0.000 claims 1
125000001309 chloro group Chemical group Cl* 0.000 claims 1
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238000004949 mass spectrometry Methods 0.000 description 28
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239000011734 sodium Substances 0.000 description 24
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230000002829 reductive effect Effects 0.000 description 23
239000011541 reaction mixture Substances 0.000 description 21
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