CA2599415C - Stable micronized candesartan cilexetil and methods for preparing thereof - Google Patents
Stable micronized candesartan cilexetil and methods for preparing thereof Download PDFInfo
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- CA2599415C CA2599415C CA2599415A CA2599415A CA2599415C CA 2599415 C CA2599415 C CA 2599415C CA 2599415 A CA2599415 A CA 2599415A CA 2599415 A CA2599415 A CA 2599415A CA 2599415 C CA2599415 C CA 2599415C
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- candesartan cilexetil
- candesartan
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- 239000007971 pharmaceutical suspension Substances 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008060 renal absorption Effects 0.000 description 1
- 230000036454 renin-angiotensin system Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000005029 sieve analysis Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000021023 sodium intake Nutrition 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67995205P | 2005-05-10 | 2005-05-10 | |
| US60/679,952 | 2005-05-10 | ||
| US68011505P | 2005-05-11 | 2005-05-11 | |
| US60/680,115 | 2005-05-11 | ||
| US68445505P | 2005-05-24 | 2005-05-24 | |
| US60/684,455 | 2005-05-24 | ||
| US70741705P | 2005-08-10 | 2005-08-10 | |
| US60/707,417 | 2005-08-10 | ||
| US70995405P | 2005-08-19 | 2005-08-19 | |
| US60/709,954 | 2005-08-19 | ||
| US71699505P | 2005-09-13 | 2005-09-13 | |
| US60/716,995 | 2005-09-13 | ||
| US72238805P | 2005-09-29 | 2005-09-29 | |
| US60/722,388 | 2005-09-29 | ||
| PCT/US2006/018265 WO2006122254A2 (en) | 2005-05-10 | 2006-05-10 | Stable micronized candesartan cilexetil and methods for preparing thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2599415A1 CA2599415A1 (en) | 2006-11-16 |
| CA2599415C true CA2599415C (en) | 2011-07-19 |
Family
ID=37101528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2599415A Expired - Fee Related CA2599415C (en) | 2005-05-10 | 2006-05-10 | Stable micronized candesartan cilexetil and methods for preparing thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070082055A1 (enIt.pdf) |
| EP (2) | EP2210888B1 (enIt.pdf) |
| JP (2) | JP2008505935A (enIt.pdf) |
| KR (1) | KR100978592B1 (enIt.pdf) |
| CA (1) | CA2599415C (enIt.pdf) |
| DE (1) | DE202006020979U1 (enIt.pdf) |
| ES (1) | ES2429941T3 (enIt.pdf) |
| IL (1) | IL185106A0 (enIt.pdf) |
| TW (1) | TW200716615A (enIt.pdf) |
| WO (1) | WO2006122254A2 (enIt.pdf) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006122254A2 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Stable micronized candesartan cilexetil and methods for preparing thereof |
| JP5595820B2 (ja) * | 2010-01-15 | 2014-09-24 | 株式会社トクヤマ | カンデサルタンシレキセチルの製造方法 |
| WO2011109579A1 (en) | 2010-03-04 | 2011-09-09 | Theravance, Inc. | Crystalline alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid and methods for preparing thereof |
| WO2013041944A1 (en) | 2011-09-19 | 2013-03-28 | Ranbaxy Laboratories Limited | Process for the preparation of micronized candesartan cilexetil |
| JP5930686B2 (ja) * | 2011-12-07 | 2016-06-08 | 株式会社トクヤマ | 溶解性および安定性の向上した難溶性医薬品原体及びその製造方法 |
| JP6007096B2 (ja) * | 2011-12-28 | 2016-10-12 | エルメッド エーザイ株式会社 | 安定化カンデサルタンシレキセチル含有物の製造方法 |
| EA201492026A1 (ru) | 2012-05-07 | 2015-09-30 | Байер Фарма Акциенгезельшафт | Способ изготовления фармацевтической лекарственной формы, содержащей нифедипин и кандесартан цилексетил |
| EP2952187A4 (en) | 2013-01-30 | 2016-08-17 | Sawai Seiyaku Kk | PHARMACEUTICAL COMPOSITION WITH CANDESARTAN CILEXETIL |
| JP2016106139A (ja) * | 2016-03-07 | 2016-06-16 | 株式会社トクヤマ | 溶解性および安定性の向上した難溶性医薬品原体及びその製造方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5703110A (en) * | 1990-04-27 | 1997-12-30 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
| US6004989A (en) * | 1990-04-27 | 1999-12-21 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
| DE4023369A1 (de) * | 1990-07-23 | 1992-01-30 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| TW284688B (enIt.pdf) * | 1991-11-20 | 1996-09-01 | Takeda Pharm Industry Co Ltd | |
| US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
| JP2730501B2 (ja) | 1994-01-28 | 1998-03-25 | 武田薬品工業株式会社 | テトラゾリル化合物の製造法 |
| ATE194603T1 (de) * | 1994-01-28 | 2000-07-15 | Takeda Chemical Industries Ltd | Ein verfahren zur herstellung von tetrazolyl- verbindungen |
| JP3003030B2 (ja) * | 1997-05-26 | 2000-01-24 | 武田薬品工業株式会社 | アミノベンゼン化合物の製造法 |
| SE9901667D0 (sv) * | 1999-05-07 | 1999-05-07 | Astra Ab | Method and device for forming particles |
| CN1204125C (zh) * | 2000-12-27 | 2005-06-01 | 中国科学院上海药物研究所 | 坎地沙坦酯的合成新路线 |
| US7067546B2 (en) * | 2001-08-03 | 2006-06-27 | Takeda Pharmaceutical Company | Crystal and process for producing the same |
| KR20090029310A (ko) * | 2004-05-05 | 2009-03-20 | 테바 파마슈티컬 인더스트리즈 리미티드 | 순도가 높은 칸데사르탄 실렉세틸의 제조 |
| WO2005123720A1 (en) * | 2004-06-18 | 2005-12-29 | Ranbaxy Laboratories Limited | Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof |
| EA200701442A1 (ru) | 2005-01-06 | 2008-02-28 | Элан Фарма Интернэшнл Лтд. | Композиции наночастиц кандесартана |
| WO2006122254A2 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Stable micronized candesartan cilexetil and methods for preparing thereof |
-
2006
- 2006-05-10 WO PCT/US2006/018265 patent/WO2006122254A2/en active Application Filing
- 2006-05-10 EP EP10156812.9A patent/EP2210888B1/en not_active Not-in-force
- 2006-05-10 CA CA2599415A patent/CA2599415C/en not_active Expired - Fee Related
- 2006-05-10 EP EP06759583A patent/EP1763525A2/en not_active Withdrawn
- 2006-05-10 JP JP2007520596A patent/JP2008505935A/ja not_active Withdrawn
- 2006-05-10 DE DE202006020979U patent/DE202006020979U1/de not_active Expired - Lifetime
- 2006-05-10 KR KR1020077002950A patent/KR100978592B1/ko not_active IP Right Cessation
- 2006-05-10 ES ES10156812T patent/ES2429941T3/es active Active
- 2006-05-10 TW TW095116575A patent/TW200716615A/zh unknown
- 2006-05-10 US US11/432,108 patent/US20070082055A1/en not_active Abandoned
-
2007
- 2007-08-07 IL IL185106A patent/IL185106A0/en unknown
-
2010
- 2010-08-10 JP JP2010179587A patent/JP2010270148A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2210888B1 (en) | 2013-04-24 |
| JP2010270148A (ja) | 2010-12-02 |
| EP2210888A2 (en) | 2010-07-28 |
| IL185106A0 (en) | 2007-12-03 |
| EP1763525A2 (en) | 2007-03-21 |
| TW200716615A (en) | 2007-05-01 |
| ES2429941T3 (es) | 2013-11-18 |
| CA2599415A1 (en) | 2006-11-16 |
| WO2006122254A2 (en) | 2006-11-16 |
| JP2008505935A (ja) | 2008-02-28 |
| KR100978592B1 (ko) | 2010-08-27 |
| DE202006020979U1 (de) | 2011-08-05 |
| KR20070062500A (ko) | 2007-06-15 |
| EP2210888A3 (en) | 2010-09-15 |
| US20070082055A1 (en) | 2007-04-12 |
| WO2006122254A3 (en) | 2007-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150511 |