CA2591042A1 - Process for the preparation of a boron-substituted porphyrin - Google Patents

Process for the preparation of a boron-substituted porphyrin Download PDF

Info

Publication number
CA2591042A1
CA2591042A1 CA002591042A CA2591042A CA2591042A1 CA 2591042 A1 CA2591042 A1 CA 2591042A1 CA 002591042 A CA002591042 A CA 002591042A CA 2591042 A CA2591042 A CA 2591042A CA 2591042 A1 CA2591042 A1 CA 2591042A1
Authority
CA
Canada
Prior art keywords
compound
formula
meta
para
ortho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002591042A
Other languages
English (en)
French (fr)
Inventor
Paul Stanley Bury
Ke-Dong Li
Anthony David Bentham
Bipin Chandra Muljibhai Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psimei Pharmaceuticals PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2591042A1 publication Critical patent/CA2591042A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/08—Copper compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002591042A 2004-12-16 2005-12-13 Process for the preparation of a boron-substituted porphyrin Abandoned CA2591042A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0427589.7 2004-12-16
GBGB0427589.7A GB0427589D0 (en) 2004-12-16 2004-12-16 Process for the preparation of a substituted porphyrin
PCT/GB2005/004784 WO2006064205A2 (en) 2004-12-16 2005-12-13 Process for the preparation of a boron-substituted porphyrin

Publications (1)

Publication Number Publication Date
CA2591042A1 true CA2591042A1 (en) 2006-06-22

Family

ID=34090168

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002591042A Abandoned CA2591042A1 (en) 2004-12-16 2005-12-13 Process for the preparation of a boron-substituted porphyrin

Country Status (12)

Country Link
US (1) US8680265B2 (OSRAM)
EP (1) EP1830882B1 (OSRAM)
JP (1) JP2008524182A (OSRAM)
KR (1) KR20070100745A (OSRAM)
CN (1) CN101098713A (OSRAM)
AU (1) AU2005315446A1 (OSRAM)
BR (1) BRPI0518951A2 (OSRAM)
CA (1) CA2591042A1 (OSRAM)
GB (2) GB0427589D0 (OSRAM)
RU (1) RU2007126569A (OSRAM)
WO (1) WO2006064205A2 (OSRAM)
ZA (1) ZA200705767B (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8287839B2 (en) * 2006-12-04 2012-10-16 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
CA2715747C (en) * 2008-02-19 2016-05-24 Health Research, Inc. B ring reduced-d ring oxidized tetrapyrollic photosensitizers for photodynamic therapy and tumor imaging
CA2930965A1 (en) * 2013-11-22 2015-05-28 Aeolus Sciences, Inc. Synthesis and formulations of porphyrin compounds
CN112010320B (zh) * 2020-08-12 2023-05-23 河南师范大学 一种b取代氰基硼氢化钠的制备方法
CN114790289B (zh) * 2022-04-24 2023-08-11 中国船舶重工集团公司第七一八研究所 一种耐高温聚酰亚胺树脂的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877165A (en) * 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
EP1404319B1 (en) * 2001-06-06 2006-03-22 Brookhaven Science Associates Novel metalloporphyrins and their uses as radiosensitizers for radiation therapy
US6995260B2 (en) 2004-05-20 2006-02-07 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof

Also Published As

Publication number Publication date
EP1830882A2 (en) 2007-09-12
US20100016613A1 (en) 2010-01-21
GB0427589D0 (en) 2005-01-19
BRPI0518951A2 (pt) 2008-12-16
US8680265B2 (en) 2014-03-25
GB2436767A (en) 2007-10-03
RU2007126569A (ru) 2009-01-27
ZA200705767B (en) 2008-09-25
CN101098713A (zh) 2008-01-02
JP2008524182A (ja) 2008-07-10
KR20070100745A (ko) 2007-10-11
EP1830882B1 (en) 2016-10-26
GB0713798D0 (en) 2007-08-22
WO2006064205A2 (en) 2006-06-22
AU2005315446A1 (en) 2006-06-22
WO2006064205A3 (en) 2007-02-01

Similar Documents

Publication Publication Date Title
JP5340953B2 (ja) カルボラニルポルフィリンとその使用
WO2008069974A1 (en) Radiation enhancement agents for x-ray radiation therapy and boron neutron-capture therapy
JP2005504012A (ja) 新規メタロポルフィリン及び放射線治療用放射線増感剤としてのそれらの使用
CN111434352B (zh) 一种具有肿瘤靶向能力的含硼药物及其制备方法和应用
US6995260B2 (en) Carboranylporphyrins and uses thereof
EP1830882B1 (en) Process for the preparation of a boron-substituted porphyrin
US20080279781A1 (en) Glycosylated Carboranylporphyrins and Uses Thereof
CN1988848B (zh) 碳硼烷基卟啉及其应用
CN115724866B (zh) 肿瘤诊疗一体化的硼携带剂、其制备方法和用途
HK1110009A (en) Process for the preparation of a substituted porphyrin
HK1122722A (en) Process for the preparation of a boron-substituted porphyrin
CN112915217B (zh) 一类前列腺癌靶向的药物前体及其合成方法
US20080233047A1 (en) Symmetric and Asymmetric Halogen-Containing Metallocarboranylporphyrins and Uses Thereof
Ratajski Boronated porphyrazines as a potential boron neutron capture therapy agent.
HK1109039B (en) Carboranylporphyrins and uses thereof
HK1107013A (en) Carboranylporphyrins and uses thereof
HK1133552B (en) Carboranylporphyrins and uses thereof

Legal Events

Date Code Title Description
FZDE Discontinued