CA2588994A1 - Methods and compositions for the treatment of pulmonary hypertension of the newborn - Google Patents

Methods and compositions for the treatment of pulmonary hypertension of the newborn Download PDF

Info

Publication number
CA2588994A1
CA2588994A1 CA002588994A CA2588994A CA2588994A1 CA 2588994 A1 CA2588994 A1 CA 2588994A1 CA 002588994 A CA002588994 A CA 002588994A CA 2588994 A CA2588994 A CA 2588994A CA 2588994 A1 CA2588994 A1 CA 2588994A1
Authority
CA
Canada
Prior art keywords
pphn
composition
crystal
medicament
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002588994A
Other languages
English (en)
French (fr)
Inventor
Emil D. Kakkis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomarin Pharmaceutical Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2588994A1 publication Critical patent/CA2588994A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002588994A 2004-12-08 2005-12-08 Methods and compositions for the treatment of pulmonary hypertension of the newborn Abandoned CA2588994A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63414704P 2004-12-08 2004-12-08
US60/634,147 2004-12-08
PCT/US2005/044587 WO2006063215A2 (en) 2004-12-08 2005-12-08 Methods and compositions for the treatment of pulmonary hypertension of the newborn

Publications (1)

Publication Number Publication Date
CA2588994A1 true CA2588994A1 (en) 2006-06-15

Family

ID=36578615

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002588994A Abandoned CA2588994A1 (en) 2004-12-08 2005-12-08 Methods and compositions for the treatment of pulmonary hypertension of the newborn

Country Status (6)

Country Link
US (1) US20100130500A1 (OSRAM)
EP (1) EP1819340A2 (OSRAM)
JP (1) JP2008523090A (OSRAM)
AU (1) AU2005313940A1 (OSRAM)
CA (1) CA2588994A1 (OSRAM)
WO (1) WO2006063215A2 (OSRAM)

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CN101132776A (zh) 2004-11-17 2008-02-27 生物马林药物股份有限公司 稳定的四氢生物喋呤片剂制剂
JP4864400B2 (ja) * 2005-09-22 2012-02-01 トヨタホーム株式会社 ラック
CA2631740A1 (en) * 2005-12-05 2007-06-14 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
SI2076501T1 (sl) * 2006-09-25 2016-05-31 Ptc Therapeutics, Inc. Kristalinične oblike 3-(5-(2-florofenil)-1,2,4) oksadiazol-3-il)-benzojske kisline
ES2524026T3 (es) 2008-01-03 2014-12-03 Biomarin Pharmaceutical Inc. Análogo de pterina para tratar una afección que responde a BH4
JP2011010865A (ja) 2009-06-30 2011-01-20 Ikaria Holdings Inc 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法
US8641613B2 (en) 2011-03-10 2014-02-04 Medicalcue, Inc. Umbilical probe system
US8727980B2 (en) 2011-03-10 2014-05-20 Medicalcue, Inc. Umbilical probe system
US8641614B2 (en) * 2011-03-10 2014-02-04 Medicalcue, Inc. Umbilical probe measurement systems
EP2713723B1 (en) * 2011-05-27 2018-09-12 Geno LLC Method of determining vasoreactivity using inhaled nitric oxide
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
AU2014203438B2 (en) 2013-06-25 2019-06-20 Mallinckrodt Hospital Products IP Limited Methods of reducing the risk of mortality associated with a medical treatment
MA46972A (fr) 2016-11-29 2019-10-09 Censa Pharmaceuticals Inc Forme polymorphe de sépiaptérine
NZ753504A (en) 2016-11-29 2025-10-31 Ptc Therapeutics Mp Inc Polymorphs of sepiapterin and salts thereof
CN111491635A (zh) 2017-09-01 2020-08-04 显莎制药公司 包含墨蝶呤的药物组合物及其用途
JP7547215B2 (ja) 2018-05-30 2024-09-09 ピーティーシー セラピューティクス エムピー,インコーポレイテッド テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法
US11617752B2 (en) 2018-05-30 2023-04-04 Ptc Therapeutics Mp, Inc. Methods for increasing sepiapterin plasma exposure

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US2601215A (en) * 1948-03-17 1952-06-17 American Cyanamid Co Process of preparing dihydropterins
US3505329A (en) * 1968-02-06 1970-04-07 Smithkline Corp Process for the synthesis of biopterin
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd 1′,2′−ジアシル−(6r,s)−5,6,7,8−テトラヒドロ−l−ビオプテリンおよびその製法
JPS5925323A (ja) * 1982-03-03 1984-02-09 鐘淵化学工業株式会社 プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤
GB8318833D0 (en) * 1983-07-12 1983-08-10 Wellcome Found Chemical compounds
ZA836957B (en) * 1982-09-20 1985-04-24 Wellcome Found Neurologically active chemical compounds
US5196533A (en) * 1983-04-11 1993-03-23 South Alabama Medical Science Foundation, Usa Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines
US4587340A (en) * 1983-09-19 1986-05-06 Burroughs Wellcome Co. Biopterin analogs
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法
JPS60199889A (ja) * 1984-03-24 1985-10-09 Kanegafuchi Chem Ind Co Ltd 5,6,7,8−テトラヒドロ−l−エリスロ−ビオプテリンの硫酸塩およびその製法
US4550109A (en) * 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds
DE3437944A1 (de) * 1984-10-17 1986-07-31 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verwendung von pterinen zur steigerung der aktivitaet von lymphokinen und anderen blutfaktoren, sowie ein diagnostisches oder therapeutisches praeparat, das pterine in kombination mit lymphokinen enthaelt
CA1262347A (en) * 1985-01-28 1989-10-17 Suntory Limited Preparation process of (6r)-tetrahydro-l-biopterin
JPS61277618A (ja) * 1985-06-04 1986-12-08 Suntory Ltd 自閉症治療剤
DE3853711T2 (de) * 1987-11-30 1996-01-11 Vitamin Kenkyusho Kk Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.
JP2534423B2 (ja) * 1991-12-26 1996-09-18 コーネル・リサーチ・ファンデーション・インコーポレイテッド 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
DE4308739C1 (de) * 1993-03-19 1994-06-23 Henning Berlin Gmbh Pterinderivate, ihre Herstellung und ihre Verwendung
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
US5945452A (en) * 1993-06-11 1999-08-31 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
ES2177654T3 (es) * 1994-08-05 2002-12-16 Suntory Ltd Remedio contra la degeneracion espinocerebelosa.
US20020076782A1 (en) * 1996-07-05 2002-06-20 John P.N. Rosazza Purified nitric oxide synthase
US6720309B1 (en) * 1996-07-17 2004-04-13 Leuven Research And Development, V.Z.W. Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene
GB9617990D0 (en) * 1996-08-29 1996-10-09 Scotia Holdings Plc Treatment of pain
DE69725721T3 (de) * 1996-08-30 2007-10-31 Daiichi Asubio Pharma Co., Ltd. Vorbeugende oder heilende mittel für krankheiten, die durch mangel an stickoxid-synthase (nos) ausgelöst sind
CH693255A5 (de) * 1997-06-13 2003-05-15 Eprova Ag Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
US5922713A (en) * 1997-06-26 1999-07-13 Werner; Ernst Inhibition of nitric oxide synthase
JP4306825B2 (ja) * 1998-02-27 2009-08-05 アスビオファーマ株式会社 インスリン抵抗性が関与する血管機能異常を伴う疾患の予防または治療剤
US6200758B1 (en) * 1999-02-19 2001-03-13 New York State Office Of Mental Health Phenylalanine hydroxylase gene variants, and amino acid and pterin homeostasis, in the definition, detection, treatment and prevention of psychotic, mood and personality disorders
US6521212B1 (en) * 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
WO2000056328A1 (en) * 1999-03-19 2000-09-28 Enos Pharmaceuticals, Inc. Increasing cerebral bioavailability of drugs
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
GB2355191A (en) * 1999-10-12 2001-04-18 Laxdale Ltd Combination formulations for fatigue, head injury and strokes
US6544994B2 (en) * 2000-06-07 2003-04-08 Eprov Ag Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase

Also Published As

Publication number Publication date
WO2006063215A3 (en) 2006-12-07
US20100130500A1 (en) 2010-05-27
JP2008523090A (ja) 2008-07-03
EP1819340A2 (en) 2007-08-22
WO2006063215A2 (en) 2006-06-15
AU2005313940A1 (en) 2006-06-15

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Legal Events

Date Code Title Description
FZDE Discontinued