CA2580349C - Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue - Google Patents

Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue Download PDF

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Publication number
CA2580349C
CA2580349C CA2580349A CA2580349A CA2580349C CA 2580349 C CA2580349 C CA 2580349C CA 2580349 A CA2580349 A CA 2580349A CA 2580349 A CA2580349 A CA 2580349A CA 2580349 C CA2580349 C CA 2580349C
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CA
Canada
Prior art keywords
silk
fibres
tubular body
nerve
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2580349A
Other languages
English (en)
French (fr)
Other versions
CA2580349A1 (en
Inventor
John Priestley
Von King
David Philip Knight
Nicholas James Vavasor Skaer
Jessica Hensman
Original Assignee
Neurotex Ltd
Newrotex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0420411A external-priority patent/GB2417904A/en
Priority claimed from GB0422019A external-priority patent/GB0422019D0/en
Application filed by Neurotex Ltd, Newrotex Ltd filed Critical Neurotex Ltd
Publication of CA2580349A1 publication Critical patent/CA2580349A1/en
Application granted granted Critical
Publication of CA2580349C publication Critical patent/CA2580349C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2580349A 2004-09-14 2005-09-08 Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue Expired - Lifetime CA2580349C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0420411A GB2417904A (en) 2004-09-14 2004-09-14 Tubular prosthesis for nerve regeneration
GB0420411.1 2004-09-14
GB0422019A GB0422019D0 (en) 2004-10-05 2004-10-05 Medical device
GB0422019.0 2004-10-05
PCT/GB2005/003456 WO2006030182A2 (en) 2004-09-14 2005-09-08 Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue

Publications (2)

Publication Number Publication Date
CA2580349A1 CA2580349A1 (en) 2006-03-23
CA2580349C true CA2580349C (en) 2014-06-17

Family

ID=35733979

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2580349A Expired - Lifetime CA2580349C (en) 2004-09-14 2005-09-08 Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue

Country Status (7)

Country Link
US (1) US8106014B2 (https=)
EP (1) EP1789103B1 (https=)
JP (1) JP4746046B2 (https=)
AT (1) ATE428453T1 (https=)
CA (1) CA2580349C (https=)
DE (1) DE602005013979D1 (https=)
WO (1) WO2006030182A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0405045D0 (en) 2004-03-05 2004-04-07 Spinox Ltd Composite materials
DE102005042455A1 (de) 2005-09-06 2007-04-12 Medizinische Hochschule Hannover Nervenimplantat
CN100382772C (zh) * 2005-09-28 2008-04-23 南通大学 含蚕丝丝素的医用神经移植物的制备方法
WO2008071226A1 (en) 2006-12-11 2008-06-19 Medizinische Hochschule Hannover Implant of cross-linked spider silk threads
US9808557B2 (en) 2007-08-10 2017-11-07 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
FR2941610A1 (fr) * 2009-02-03 2010-08-06 Xavier Renard Dispositif pour relier au moins deux portions d'un nerf sectionne
KR101151358B1 (ko) * 2010-03-17 2012-06-08 동국대학교 산학협력단 실크 및 콜라겐을 포함하는 복합 지지체 및 그 제조방법
US8758374B2 (en) 2010-09-15 2014-06-24 University Of Utah Research Foundation Method for connecting nerves via a side-to-side epineurial window using artificial conduits
GB201113856D0 (en) 2011-08-11 2011-09-28 Oxford Biomaterials Ltd Medical device
US9931121B2 (en) 2011-10-17 2018-04-03 University Of Utah Research Foundation Methods and devices for connecting nerves
US10842494B2 (en) 2011-10-17 2020-11-24 University Of Utah Research Foundation Methods and devices for connecting nerves
CN102732525B (zh) * 2012-06-29 2014-02-26 苏州大学 一种用于克隆含精氨酸-甘氨酸-天门冬氨酸的多肽的dna分子及克隆方法
JP2015536919A (ja) * 2012-10-11 2015-12-24 タフツ ユニバーシティー 抗癌剤の持続送達のためのシルクリザーバ
US20140170162A1 (en) * 2012-12-18 2014-06-19 The Regents Of The University Of California Preservation of the neuromuscular junction (nmj) after traumatic nerve injury
JP2014155622A (ja) * 2013-02-15 2014-08-28 Terumo Corp 管状体
JP6377079B2 (ja) * 2013-02-19 2018-08-22 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 化学勾配
US10363041B2 (en) * 2013-06-24 2019-07-30 The Trustees Of The Stevens Institute Of Technology Implantable nerve guidance conduits having polymer fiber guidance channel
US20150044259A1 (en) * 2013-08-08 2015-02-12 Mauris N. DeSilva Scaffold for enhanced neural tissue regeneration
WO2015023798A1 (en) * 2013-08-13 2015-02-19 Lewis, Randolph, V. Synthetic spider silk protein compositions and methods
WO2016077839A1 (en) * 2014-11-15 2016-05-19 Tissuegen, Inc. Device for induction of cellular activity and modification
EP3865101A1 (en) * 2015-07-20 2021-08-18 Tufts University Biodegradable silk ear tubes
US10420939B2 (en) 2016-03-31 2019-09-24 The Cleveland Clinic Foundation Nerve stimulation to promote neuroregeneration
EP3490624B1 (en) * 2016-08-01 2022-02-09 Association for the Advancement of Tissue Engineering and Cell based Technologies & Therapies (A4TEC) - Associação Nerve guidance conduits, methods of production and uses thereof
CN109513041B (zh) * 2018-12-29 2023-10-03 南通纺织丝绸产业技术研究院 一种镁丝蚕丝复合编织结构神经导管及其制备方法
CA3183969A1 (en) 2020-07-08 2022-01-13 Alexander Woods Bridging peripheral nerve gaps with conduits for enhanced nerve regeneration
EP3991762A1 (en) 2020-11-02 2022-05-04 Medizinische Hochschule Hannover Implant for nerve regeneration
CN116019606A (zh) * 2023-01-31 2023-04-28 重庆市畜牧科学院 一种视神经接口的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019087A (en) 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
US5026381A (en) 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US5656605A (en) * 1994-01-26 1997-08-12 Institute Of Molecular Biology, Inc. Device to promote drug-induced nerve regeneration
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
TW528600B (en) 1996-11-20 2003-04-21 Yasuhiko Shimizu Artificial neural canal
WO1999063908A1 (en) 1998-06-10 1999-12-16 Tapic International Co., Ltd. Artificial neural tube
US6676675B2 (en) 2000-04-19 2004-01-13 Iowa State University Research Foundation, Inc. Patterned substrates and methods for nerve regeneration
JP3771510B2 (ja) * 2001-04-13 2006-04-26 泰彦 田畑 組織の体内再生用材料
US6716225B2 (en) 2001-08-02 2004-04-06 Collagen Matrix, Inc. Implant devices for nerve repair
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
TWI264301B (en) * 2002-03-11 2006-10-21 Ind Tech Res Inst Multi-channel bioresorbable nerve regeneration conduit and preparation method for the same
EP2662211A1 (en) * 2002-06-24 2013-11-13 Tufts University Silk biomaterials and methods of use thereof
JP3840541B2 (ja) 2002-11-25 2006-11-01 独立行政法人農業生物資源研究所 医療用基材としての繭糸構造物及びその製造法

Also Published As

Publication number Publication date
EP1789103B1 (en) 2009-04-15
DE602005013979D1 (de) 2009-05-28
WO2006030182A2 (en) 2006-03-23
CA2580349A1 (en) 2006-03-23
EP1789103A2 (en) 2007-05-30
WO2006030182A3 (en) 2006-05-04
US8106014B2 (en) 2012-01-31
JP4746046B2 (ja) 2011-08-10
JP2008513051A (ja) 2008-05-01
ATE428453T1 (de) 2009-05-15
US20090099580A1 (en) 2009-04-16

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