CA2568907C - 8-carbyl substituted cyclic adenosine-3',5'-monophosphorothiolate compounds as camp modulators - Google Patents

8-carbyl substituted cyclic adenosine-3',5'-monophosphorothiolate compounds as camp modulators Download PDF

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Publication number
CA2568907C
CA2568907C CA2568907A CA2568907A CA2568907C CA 2568907 C CA2568907 C CA 2568907C CA 2568907 A CA2568907 A CA 2568907A CA 2568907 A CA2568907 A CA 2568907A CA 2568907 C CA2568907 C CA 2568907C
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CA
Canada
Prior art keywords
camps
mmol
adenosine
cyclic
camp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2568907A
Other languages
English (en)
French (fr)
Other versions
CA2568907A1 (en
Inventor
Kjell Undheim
Kjetil Tasken
Jo Klaveness
Geir Langli
Vidar Bjornstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biolog Life Science Institute Forschungslabor und Biochemica Vertrieb GmbH
Original Assignee
Biolog Life Science Institute Forschungslabor und Biochemica Vertrieb GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolog Life Science Institute Forschungslabor und Biochemica Vertrieb GmbH filed Critical Biolog Life Science Institute Forschungslabor und Biochemica Vertrieb GmbH
Publication of CA2568907A1 publication Critical patent/CA2568907A1/en
Application granted granted Critical
Publication of CA2568907C publication Critical patent/CA2568907C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2568907A 2004-06-18 2005-06-20 8-carbyl substituted cyclic adenosine-3',5'-monophosphorothiolate compounds as camp modulators Expired - Fee Related CA2568907C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0413726.1 2004-06-18
GBGB0413726.1A GB0413726D0 (en) 2004-06-18 2004-06-18 Compounds
PCT/GB2005/002418 WO2005123755A2 (en) 2004-06-18 2005-06-20 Purine nucleotide derivatives

Publications (2)

Publication Number Publication Date
CA2568907A1 CA2568907A1 (en) 2005-12-29
CA2568907C true CA2568907C (en) 2015-06-09

Family

ID=32750205

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2568907A Expired - Fee Related CA2568907C (en) 2004-06-18 2005-06-20 8-carbyl substituted cyclic adenosine-3',5'-monophosphorothiolate compounds as camp modulators

Country Status (10)

Country Link
US (1) US8153609B2 (enExample)
EP (1) EP1765844B1 (enExample)
JP (1) JP5044750B2 (enExample)
CN (1) CN101001865A (enExample)
AU (1) AU2005254790B2 (enExample)
CA (1) CA2568907C (enExample)
DK (1) DK1765844T3 (enExample)
ES (1) ES2496946T3 (enExample)
GB (1) GB0413726D0 (enExample)
WO (1) WO2005123755A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007006544A2 (en) * 2005-07-12 2007-01-18 Vrije Universiteit Brussel Cyclic adenosine monophosphate compounds for the treatment of immune-related disorders
GB0618235D0 (en) 2006-09-15 2006-10-25 Lauras As Process
EP2448968B1 (en) * 2009-06-29 2021-01-27 BioArctic AB ANTIBODIES SELECTIVE FOR N-TERMINALTRUNCATED AMYLOID-p PROTOFIBRILS/OLIGOMERS
EA025341B1 (ru) 2010-09-22 2016-12-30 Алиос Биофарма, Инк. Замещенные аналоги нуклеотидов
AU2011349278C1 (en) * 2010-12-22 2017-01-19 Alios Biopharma, Inc. Cyclic nucleotide analogs
EP2794627B1 (en) 2011-12-22 2018-09-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013096680A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
US8916538B2 (en) 2012-03-21 2014-12-23 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
WO2022216577A1 (en) * 2021-04-09 2022-10-13 Merck Sharp & Dohme Llc Novel forms of cyclic dinucleotide compounds
WO2023031481A1 (en) 2021-09-06 2023-03-09 Mireca Medicines Gmbh Improved methods for production of cyclic guanosine-monophosphate analogues

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968101A (en) 1974-12-20 1976-07-06 Icn Pharmaceuticals, Inc. 8-Substituted cyclic nucleotides by free radical alkylation and acylation
WO1989007108A1 (en) * 1988-02-01 1989-08-10 Bernd Jastorff Process for producing nucleoside-3',5'-cyclophosphates and nucleoside-3',5'-cyclothiophosphates
AU4226693A (en) 1992-05-01 1993-11-29 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Phosphorothioate derivatives of cyclic AMP analogues
US5625056A (en) * 1992-05-26 1997-04-29 Biolog Life Science Institute Derivatives of cyclic guanosine-3',5'-monophosphorothioate
NO971997D0 (no) 1997-04-29 1997-04-29 Kjetil Tasken Bruk av immunmodulerende midler
CA2488611C (en) * 2002-06-07 2011-11-15 Kylix, B.V. Compounds for modulating the activity of exchange proteins directly activated by camp (epacs)

Also Published As

Publication number Publication date
CA2568907A1 (en) 2005-12-29
AU2005254790B2 (en) 2012-02-23
GB0413726D0 (en) 2004-07-21
EP1765844A2 (en) 2007-03-28
JP2008502673A (ja) 2008-01-31
DK1765844T3 (da) 2014-09-01
AU2005254790A1 (en) 2005-12-29
WO2005123755A2 (en) 2005-12-29
ES2496946T3 (es) 2014-09-22
US20080293665A1 (en) 2008-11-27
CN101001865A (zh) 2007-07-18
JP5044750B2 (ja) 2012-10-10
WO2005123755A3 (en) 2006-04-06
US8153609B2 (en) 2012-04-10
EP1765844B1 (en) 2014-07-30

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Effective date: 20190620