ES2496946T3 - Derivados de nucleótidos de purina - Google Patents

Derivados de nucleótidos de purina Download PDF

Info

Publication number
ES2496946T3
ES2496946T3 ES05755520.3T ES05755520T ES2496946T3 ES 2496946 T3 ES2496946 T3 ES 2496946T3 ES 05755520 T ES05755520 T ES 05755520T ES 2496946 T3 ES2496946 T3 ES 2496946T3
Authority
ES
Spain
Prior art keywords
cyclic
mmol
adenosine
nmr
ampsc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05755520.3T
Other languages
English (en)
Spanish (es)
Inventor
Kjell Undheim
Kjetil TASKÉN
Jo Klaveness
Geir Langli
Vidar BJØRNSTAD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solvell AS
Original Assignee
Solvell AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvell AS filed Critical Solvell AS
Application granted granted Critical
Publication of ES2496946T3 publication Critical patent/ES2496946T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ES05755520.3T 2004-06-18 2005-06-20 Derivados de nucleótidos de purina Expired - Lifetime ES2496946T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0413726.1A GB0413726D0 (en) 2004-06-18 2004-06-18 Compounds
GB0413726 2004-06-18
PCT/GB2005/002418 WO2005123755A2 (en) 2004-06-18 2005-06-20 Purine nucleotide derivatives

Publications (1)

Publication Number Publication Date
ES2496946T3 true ES2496946T3 (es) 2014-09-22

Family

ID=32750205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05755520.3T Expired - Lifetime ES2496946T3 (es) 2004-06-18 2005-06-20 Derivados de nucleótidos de purina

Country Status (10)

Country Link
US (1) US8153609B2 (enExample)
EP (1) EP1765844B1 (enExample)
JP (1) JP5044750B2 (enExample)
CN (1) CN101001865A (enExample)
AU (1) AU2005254790B2 (enExample)
CA (1) CA2568907C (enExample)
DK (1) DK1765844T3 (enExample)
ES (1) ES2496946T3 (enExample)
GB (1) GB0413726D0 (enExample)
WO (1) WO2005123755A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007006544A2 (en) * 2005-07-12 2007-01-18 Vrije Universiteit Brussel Cyclic adenosine monophosphate compounds for the treatment of immune-related disorders
GB0618235D0 (en) * 2006-09-15 2006-10-25 Lauras As Process
SI2448968T1 (sl) * 2009-06-29 2021-07-30 Bioarctic Ab Protitelesa, selektivna za protofibrile/oligomere na N-koncu skrajšanega amiloida-beta
WO2012040127A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
US8772474B2 (en) 2010-12-22 2014-07-08 Alios Biopharma, Inc. Cyclic nucleotide analogs
KR102072041B1 (ko) 2011-12-22 2020-01-31 앨리오스 바이오파마 인크. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
WO2022216577A1 (en) * 2021-04-09 2022-10-13 Merck Sharp & Dohme Llc Novel forms of cyclic dinucleotide compounds
US20240352056A1 (en) 2021-09-06 2024-10-24 Mireca Medicines Gmbh Improved methods for production of cyclic guanosine-monophosphate analogues

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968101A (en) 1974-12-20 1976-07-06 Icn Pharmaceuticals, Inc. 8-Substituted cyclic nucleotides by free radical alkylation and acylation
WO1989007108A1 (en) * 1988-02-01 1989-08-10 Bernd Jastorff Process for producing nucleoside-3',5'-cyclophosphates and nucleoside-3',5'-cyclothiophosphates
AU4226693A (en) 1992-05-01 1993-11-29 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Phosphorothioate derivatives of cyclic AMP analogues
US5625056A (en) 1992-05-26 1997-04-29 Biolog Life Science Institute Derivatives of cyclic guanosine-3',5'-monophosphorothioate
NO971997D0 (no) 1997-04-29 1997-04-29 Kjetil Tasken Bruk av immunmodulerende midler
AU2003242672B2 (en) * 2002-06-07 2009-12-17 Universitair Medisch Centrum Utrecht New compounds for modulating the activity of exhange proteins directly activated by camp (EPACS)

Also Published As

Publication number Publication date
EP1765844A2 (en) 2007-03-28
WO2005123755A3 (en) 2006-04-06
AU2005254790B2 (en) 2012-02-23
EP1765844B1 (en) 2014-07-30
AU2005254790A1 (en) 2005-12-29
CA2568907C (en) 2015-06-09
JP5044750B2 (ja) 2012-10-10
GB0413726D0 (en) 2004-07-21
CA2568907A1 (en) 2005-12-29
WO2005123755A2 (en) 2005-12-29
DK1765844T3 (da) 2014-09-01
US8153609B2 (en) 2012-04-10
US20080293665A1 (en) 2008-11-27
CN101001865A (zh) 2007-07-18
JP2008502673A (ja) 2008-01-31

Similar Documents

Publication Publication Date Title
CA2828326C (en) Phosphoramidate derivatives of 5 - fluoro - 2' - deoxyuridine for use in the treatment of cancer
TWI767201B (zh) 絲狀病毒科病毒感染之治療
EP2609923B1 (en) Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
KR102363946B1 (ko) HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드
US20100137576A1 (en) 5' o [(n acyl)amidophosphate] and 5' o [(n acyl)amidothiophosphate] and 5' o [(n acyl)amidodithiophosphate] and 5' o [(n acyl)amidoselenophosphate] derivatives of nucleosides and processes for the manufacture thereof
JP6646668B2 (ja) 抗がん性化合物としての新規な２’および／または５’アミノ酸エステルホスホロアミダート３’−デオキシアデノシン誘導体
KR20030022295A (ko) 포스포네이트 뉴클레오티드 유사체의 전구약물과 그것의선택 및 제조 방법
KR20060008297A (ko) 2'-데옥시-β-Ｌ-뉴클레오시드의 제조방법
CA2568907C (en) 8-carbyl substituted cyclic adenosine-3',5'-monophosphorothiolate compounds as camp modulators
US20150291640A1 (en) Phosphonucleosides useful in the treatment of viral disorders
WO2021098379A1 (zh) 苯丙氨酸酰胺化的核苷酸衍生物及其制备方法与应用
EP3820879B1 (en) Phosphorus-containing prodrugs of gemcitabine
Piperno et al. Recent highlights in the synthesis of anti-HCV ribonucleosides
CN1812995A (zh) 工业化规模的核苷合成
CN111836823A (zh) β修饰磷酸化合物前体、β修饰磷酸化合物、反应阻碍剂和包含这些化合物的医药品以及反应阻碍方法
EP0799834A1 (en) Modified nucleotides
EP2509990A1 (en) Novel phosph(on)ate- and sulf(on)ate-based phosphate modified nucleosides useful as substrates for polymerases and as antiviral agents
SM Miranda et al. The Chemistry of Anti-HCV Nucleosides and Pro-Nucleotides
Perlíková Synthesis of novel cytostatic deazapurine nucleosides and pronucleotides
Giofrè et al. Phosphonated isoxazolidinyl nucleosides, a new class of modified nucleosides
HK1182938B (en) Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
TW201210602A (en) Phosphorus-containing prodrugs and their therapeutic use