CA2568805C - Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique - Google Patents
Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique Download PDFInfo
- Publication number
- CA2568805C CA2568805C CA2568805A CA2568805A CA2568805C CA 2568805 C CA2568805 C CA 2568805C CA 2568805 A CA2568805 A CA 2568805A CA 2568805 A CA2568805 A CA 2568805A CA 2568805 C CA2568805 C CA 2568805C
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- wetting
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- Expired - Fee Related
Links
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/088—Passive control of flow resistance by specific surface properties
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
- F05C2225/00—Synthetic polymers, e.g. plastics; Rubber
- F05C2225/04—PTFE [PolyTetraFluorEthylene]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0406080 | 2004-06-04 | ||
| FR0406080A FR2871150B1 (fr) | 2004-06-04 | 2004-06-04 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
| PCT/FR2005/001385 WO2006003293A2 (fr) | 2004-06-04 | 2005-06-06 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2568805A1 CA2568805A1 (fr) | 2006-01-12 |
| CA2568805C true CA2568805C (fr) | 2012-08-28 |
Family
ID=34946857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2568805A Expired - Fee Related CA2568805C (fr) | 2004-06-04 | 2005-06-06 | Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080110753A1 (zh) |
| EP (1) | EP1781409B1 (zh) |
| JP (1) | JP4763690B2 (zh) |
| KR (1) | KR101179411B1 (zh) |
| CN (1) | CN101031362B (zh) |
| AT (1) | ATE540756T1 (zh) |
| CA (1) | CA2568805C (zh) |
| FR (1) | FR2871150B1 (zh) |
| WO (1) | WO2006003293A2 (zh) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2871076A1 (fr) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
| JP4632300B2 (ja) * | 2005-02-14 | 2011-02-16 | 国立大学法人 筑波大学 | 送液装置 |
| JP4893197B2 (ja) * | 2006-09-28 | 2012-03-07 | ブラザー工業株式会社 | 液体移送装置 |
| US8702938B2 (en) * | 2007-09-04 | 2014-04-22 | Advanced Liquid Logic, Inc. | Droplet actuator with improved top substrate |
| NZ584963A (en) | 2007-10-02 | 2012-11-30 | Theranos Inc | Modular Point-of-care devices as addressible assay units with tips of assay units having interior to immobilize reagents by capillary action |
| JP5383138B2 (ja) * | 2008-10-01 | 2014-01-08 | シャープ株式会社 | エレクトロウエッティングバルブ付き送液構造体、これを用いたマイクロ分析チップ及び分析装置 |
| US8877512B2 (en) * | 2009-01-23 | 2014-11-04 | Advanced Liquid Logic, Inc. | Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator |
| US8926065B2 (en) | 2009-08-14 | 2015-01-06 | Advanced Liquid Logic, Inc. | Droplet actuator devices and methods |
| US8734628B2 (en) * | 2010-03-10 | 2014-05-27 | Empire Technology Development, Llc | Microfluidic channel device with array of drive electrodes |
| WO2011137533A1 (en) | 2010-05-05 | 2011-11-10 | The Governing Council Of The University Of Toronto | Method of processing dried samples using digital microfluidic device |
| CN101865928B (zh) * | 2010-05-06 | 2012-07-18 | 大连理工大学 | 一种基于电场作用的超疏水表面微液滴操控方法 |
| JP4949506B2 (ja) * | 2010-07-16 | 2012-06-13 | シャープ株式会社 | 流路構造体及びその製造方法、並びに、分析チップ及び分析装置 |
| CA2813090C (en) * | 2010-10-01 | 2019-11-12 | The Governing Council Of The University Of Toronto | Digital microfluidic devices and methods incorporating a solid phase |
| JP2012150098A (ja) * | 2010-12-28 | 2012-08-09 | Sharp Corp | 検体検出用チップ、それを用いたセンサ、及び検体検出方法 |
| TW202208825A (zh) | 2011-01-21 | 2022-03-01 | 美商拉布拉多診斷有限責任公司 | 樣本使用最大化之系統及方法 |
| US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
| US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
| US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
| US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
| US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
| US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
| US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
| US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
| US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| TWI624543B (zh) * | 2011-09-25 | 2018-05-21 | 賽瑞諾斯有限公司 | 用於多重分析的系統和方法 |
| US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
| CN102824933B (zh) * | 2012-09-20 | 2014-09-03 | 复旦大学 | 一种单向液滴输运的数字微流芯片电极配置方法 |
| US9366647B2 (en) * | 2013-03-14 | 2016-06-14 | Taiwan Semiconductor Manufacturing Company, Ltd. | Optical detection for bio-entities |
| US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
| TWI507690B (zh) * | 2014-09-02 | 2015-11-11 | Silicon Optronics Inc | 生物晶片構裝 |
| US20200390811A1 (en) * | 2015-04-23 | 2020-12-17 | The Trustees Of The University Of Pennsylvania | Compositions to disrupt protein kinase a anchoring and uses thereof |
| WO2016197103A1 (en) | 2015-06-05 | 2016-12-08 | Miroculus Inc. | Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling |
| EP3303548A4 (en) | 2015-06-05 | 2019-01-02 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
| EP3344388B1 (en) * | 2015-09-02 | 2020-11-11 | Tecan Trading AG | Magnetic conduits in microfluidics |
| WO2018039281A1 (en) | 2016-08-22 | 2018-03-01 | Miroculus Inc. | Feedback system for parallel droplet control in a digital microfluidic device |
| CN110383061A (zh) | 2016-12-28 | 2019-10-25 | 米罗库鲁斯公司 | 数字微流控设备和方法 |
| WO2018187476A1 (en) | 2017-04-04 | 2018-10-11 | Miroculus Inc. | Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets |
| US11413617B2 (en) | 2017-07-24 | 2022-08-16 | Miroculus Inc. | Digital microfluidics systems and methods with integrated plasma collection device |
| EP3676009A4 (en) | 2017-09-01 | 2021-06-16 | Miroculus Inc. | DIGITAL MICROFLUIDIC DEVICES AND THEIR METHODS OF USE |
| CN112469504A (zh) | 2018-05-23 | 2021-03-09 | 米罗库鲁斯公司 | 对数字微流控中的蒸发的控制 |
| EP3932537A4 (en) * | 2019-02-25 | 2023-01-04 | National Institute Of Advanced Industrial Science And Technology | OPEN SPACE TYPE LIQUID HANDLING DEVICE |
| EP3953041A4 (en) | 2019-04-08 | 2023-01-25 | Miroculus Inc. | MULTIPLE CARTRIDGE DIGITAL MICROFLUIDIC APPARATUS AND METHODS OF USE |
| WO2021016614A1 (en) | 2019-07-25 | 2021-01-28 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
| CN111804354B (zh) | 2020-04-07 | 2021-09-21 | 苏州大学 | 液滴无损转移装置及方法、液滴微反应方法 |
| US11857961B2 (en) | 2022-01-12 | 2024-01-02 | Miroculus Inc. | Sequencing by synthesis using mechanical compression |
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| CN1329729C (zh) * | 1996-06-28 | 2007-08-01 | 卡钳生命科学股份有限公司 | 微流体系统 |
| JP3791999B2 (ja) * | 1997-03-24 | 2006-06-28 | 株式会社アドバンス | 液体微粒子ハンドリング装置 |
| JP3829491B2 (ja) * | 1998-08-27 | 2006-10-04 | 株式会社日立製作所 | プローブチップ、プローブチップ作成方法、試料検出方法、及び試料検出装置 |
| US6565727B1 (en) * | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
| JP2002027984A (ja) * | 2000-07-17 | 2002-01-29 | Mitsubishi Chemicals Corp | マイクロリアクタチップ，化学反応試験方法及びマイクロリアクタチップ用薄膜部材 |
| JP2002031638A (ja) * | 2000-07-17 | 2002-01-31 | Mitsubishi Chemicals Corp | 生体試料検出用チップ及び生体試料検出方法 |
| US6773566B2 (en) * | 2000-08-31 | 2004-08-10 | Nanolytics, Inc. | Electrostatic actuators for microfluidics and methods for using same |
| JP2003222611A (ja) * | 2001-11-20 | 2003-08-08 | Nec Corp | 分離装置、分離方法および分離装置の製造方法 |
| JP2005510347A (ja) * | 2001-11-26 | 2005-04-21 | ケック グラデュエイト インスティテュート | 化学、生化学、および生物学的アッセイ等のためにエレクトロウェッティングを介してマイクロ流体制御する方法、装置、および物 |
| JP2003230829A (ja) * | 2001-12-06 | 2003-08-19 | Hitachi Ltd | 平面マイクロファクトリー |
| US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
| JP2003294733A (ja) * | 2002-03-29 | 2003-10-15 | Sumitomo Bakelite Co Ltd | 細胞内蛋白量の同定方法及び基板 |
| JP3914806B2 (ja) * | 2002-04-09 | 2007-05-16 | 三菱化学株式会社 | 分析用チップ |
| KR100455293B1 (ko) * | 2002-05-15 | 2004-11-06 | 삼성전자주식회사 | 친수성 영역과 소수성 영역으로 구성되는 생물분자용어레이 판의 제조방법 |
| WO2004008132A1 (ja) * | 2002-07-11 | 2004-01-22 | Mitsubishi Denki Kabushiki Kaisha | 生体分子分離セル及びその製造方法並びにｄｎａ分取装置 |
| JP2004061229A (ja) * | 2002-07-26 | 2004-02-26 | Hitachi Ltd | 感染症検査装置、検査方法、及び感染検査用マイクロファブリケーション |
| US6989234B2 (en) * | 2002-09-24 | 2006-01-24 | Duke University | Method and apparatus for non-contact electrostatic actuation of droplets |
| US7329545B2 (en) * | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| US6911132B2 (en) * | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| JP4590542B2 (ja) * | 2003-06-10 | 2010-12-01 | 国立大学法人九州工業大学 | マイクロ液滴輸送デバイス |
| JP4385124B2 (ja) * | 2004-03-12 | 2009-12-16 | 国立大学法人九州工業大学 | 電気的制御可能な微量液滴輸送デバイス |
| FR2871076A1 (fr) * | 2004-06-04 | 2005-12-09 | Univ Lille Sciences Tech | Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique |
| US20060266700A1 (en) * | 2005-05-31 | 2006-11-30 | General Electric Company | Porous structures with engineered wettability properties and methods of making them |
-
2004
- 2004-06-04 FR FR0406080A patent/FR2871150B1/fr not_active Expired - Fee Related
-
2005
- 2005-06-06 JP JP2007514033A patent/JP4763690B2/ja not_active Expired - Fee Related
- 2005-06-06 EP EP05775767A patent/EP1781409B1/fr not_active Not-in-force
- 2005-06-06 AT AT05775767T patent/ATE540756T1/de active
- 2005-06-06 KR KR1020067025513A patent/KR101179411B1/ko not_active IP Right Cessation
- 2005-06-06 WO PCT/FR2005/001385 patent/WO2006003293A2/fr active Application Filing
- 2005-06-06 CN CN2005800240790A patent/CN101031362B/zh not_active Expired - Fee Related
- 2005-06-06 US US11/628,416 patent/US20080110753A1/en not_active Abandoned
- 2005-06-06 CA CA2568805A patent/CA2568805C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR101179411B1 (ko) | 2012-09-07 |
| JP4763690B2 (ja) | 2011-08-31 |
| KR20070053165A (ko) | 2007-05-23 |
| CN101031362B (zh) | 2012-01-11 |
| CN101031362A (zh) | 2007-09-05 |
| EP1781409A2 (fr) | 2007-05-09 |
| FR2871150A1 (fr) | 2005-12-09 |
| JP2008502882A (ja) | 2008-01-31 |
| FR2871150B1 (fr) | 2006-09-22 |
| EP1781409B1 (fr) | 2012-01-11 |
| WO2006003293A2 (fr) | 2006-01-12 |
| US20080110753A1 (en) | 2008-05-15 |
| CA2568805A1 (fr) | 2006-01-12 |
| WO2006003293A3 (fr) | 2006-09-21 |
| ATE540756T1 (de) | 2012-01-15 |
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