CA2563010A1 - Novel 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydroisoindol-1-one/5,6-dihydro-furo[2,3-c]pyrrol-4one derivatives ligands for alpha 7 nicotinic acetylcholine receptor - Google Patents
Novel 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydroisoindol-1-one/5,6-dihydro-furo[2,3-c]pyrrol-4one derivatives ligands for alpha 7 nicotinic acetylcholine receptor Download PDFInfo
- Publication number
- CA2563010A1 CA2563010A1 CA002563010A CA2563010A CA2563010A1 CA 2563010 A1 CA2563010 A1 CA 2563010A1 CA 002563010 A CA002563010 A CA 002563010A CA 2563010 A CA2563010 A CA 2563010A CA 2563010 A1 CA2563010 A1 CA 2563010A1
- Authority
- CA
- Canada
- Prior art keywords
- aza
- oct
- dihydro
- bicyclo
- isoindol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 108700006085 alpha7 Nicotinic Acetylcholine Receptor Proteins 0.000 title description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400970-0 | 2004-04-14 | ||
| SE0400970A SE0400970D0 (sv) | 2004-04-14 | 2004-04-14 | Nicotinic acetylcholine receptor ligands |
| PCT/SE2005/000500 WO2005100351A1 (en) | 2004-04-14 | 2005-04-06 | NOVEL 2-(1-AZA-BICYCLO[2.2.2]OCT-3-yl)-2,3-DIHYDROISOINDOL-l-ONE/5,6-DIHYDRO-FURO[2,3-c]PYRROL-4ONE DERIVATIVES LIGANDS FOR ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2563010A1 true CA2563010A1 (en) | 2005-10-27 |
Family
ID=32294312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002563010A Abandoned CA2563010A1 (en) | 2004-04-14 | 2005-04-06 | Novel 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydroisoindol-1-one/5,6-dihydro-furo[2,3-c]pyrrol-4one derivatives ligands for alpha 7 nicotinic acetylcholine receptor |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7566727B2 (enExample) |
| EP (1) | EP1737854A1 (enExample) |
| JP (1) | JP2007532637A (enExample) |
| CN (1) | CN1968951A (enExample) |
| AU (1) | AU2005233492B2 (enExample) |
| BR (1) | BRPI0509777A (enExample) |
| CA (1) | CA2563010A1 (enExample) |
| IL (1) | IL178241A0 (enExample) |
| NO (1) | NO20065199L (enExample) |
| RU (2) | RU2372350C2 (enExample) |
| SE (1) | SE0400970D0 (enExample) |
| UA (1) | UA86617C2 (enExample) |
| WO (1) | WO2005100351A1 (enExample) |
| ZA (1) | ZA200608412B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| TW200804281A (en) * | 2006-02-16 | 2008-01-16 | Astrazeneca Ab | New metabotropic glutamate receptor-potentiating isoindolones |
| TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途 |
| WO2009042907A1 (en) * | 2007-09-27 | 2009-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
| US8669259B2 (en) | 2009-08-26 | 2014-03-11 | Merck Sharp & Dohme Corp. | Heterocyclic amide compounds as protein kinase inhibitors |
| KR101758046B1 (ko) * | 2009-12-22 | 2017-07-14 | 버텍스 파마슈티칼스 인코포레이티드 | 포스파티딜이노시톨 3-키나제의 이소인돌리논 억제제 |
| KR20120125618A (ko) | 2009-12-31 | 2012-11-16 | 피라말 헬쓰케어 리미티드 | 디아실글리세롤 아실 전이효소의 억제제 |
| JO3383B1 (ar) * | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
| US10329289B2 (en) | 2015-12-23 | 2019-06-25 | Merck Sharp & Dohme Corp. | 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| KR20190093205A (ko) | 2016-12-21 | 2019-08-08 | 바이오테릭스, 인코포레이티드 | 단백질 표적화에 사용하기 위한 티에노피롤 유도체, 조성물, 방법 및 이의 용도 |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| WO2018210229A1 (zh) * | 2017-05-18 | 2018-11-22 | 南京明德新药研发股份有限公司 | α-7尼古丁乙酰胆碱受体激动剂及应用 |
| CN107188900B (zh) * | 2017-05-27 | 2019-09-06 | 北京师范大学 | α7烟碱型乙酰胆碱受体的配体化合物及其应用 |
| WO2018226545A1 (en) * | 2017-06-09 | 2018-12-13 | Merck Sharp & Dohme Corp. | Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2019000238A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000236A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000237A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| EP4251149A4 (en) * | 2020-11-24 | 2024-10-30 | Merck Sharp & Dohme LLC | MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
| SE9201478D0 (sv) * | 1992-05-11 | 1992-05-11 | Kabi Pharmacia Ab | Heteroaromatic quinuclidinenes, their use and preparation |
| NO2005012I1 (no) * | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| IT1303123B1 (it) * | 1998-10-13 | 2000-10-30 | Rotta Research Lab | Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed |
| DE10045112A1 (de) | 2000-09-11 | 2002-03-21 | Merck Patent Gmbh | Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems |
| ATE385497T1 (de) * | 2000-12-01 | 2008-02-15 | Neurosearch As | 3-substituierte quinuclidin-derivate und deren verwendung als nikotinischen agonisten |
| DE10118551A1 (de) * | 2001-04-14 | 2002-10-17 | Merck Patent Gmbh | Nikotinische Acetylcholinrezeptor Liganden |
| NZ529880A (en) * | 2001-07-06 | 2005-09-30 | Neurosearch As | Novel compounds, their preparation and use |
| EP1532144B1 (en) * | 2002-08-14 | 2008-01-23 | Neurosearch A/S | quinuclidine derivatives and their use |
-
2004
- 2004-04-14 SE SE0400970A patent/SE0400970D0/xx unknown
-
2005
- 2005-04-06 CN CNA2005800194932A patent/CN1968951A/zh active Pending
- 2005-04-06 EP EP05722314A patent/EP1737854A1/en not_active Withdrawn
- 2005-04-06 JP JP2007508300A patent/JP2007532637A/ja active Pending
- 2005-04-06 WO PCT/SE2005/000500 patent/WO2005100351A1/en not_active Ceased
- 2005-04-06 CA CA002563010A patent/CA2563010A1/en not_active Abandoned
- 2005-04-06 AU AU2005233492A patent/AU2005233492B2/en not_active Expired - Fee Related
- 2005-04-06 RU RU2006135481/04A patent/RU2372350C2/ru not_active IP Right Cessation
- 2005-04-06 US US10/599,839 patent/US7566727B2/en not_active Expired - Fee Related
- 2005-04-06 BR BRPI0509777-0A patent/BRPI0509777A/pt not_active IP Right Cessation
- 2005-06-04 UA UAA200610315A patent/UA86617C2/ru unknown
-
2006
- 2006-09-21 IL IL178241A patent/IL178241A0/en unknown
- 2006-10-09 ZA ZA200608412A patent/ZA200608412B/xx unknown
- 2006-11-13 NO NO20065199A patent/NO20065199L/no not_active Application Discontinuation
-
2009
- 2009-07-10 RU RU2009126341/04A patent/RU2009126341A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006135481A (ru) | 2008-05-20 |
| US7566727B2 (en) | 2009-07-28 |
| IL178241A0 (en) | 2006-12-31 |
| SE0400970D0 (sv) | 2004-04-14 |
| NO20065199L (no) | 2006-11-13 |
| WO2005100351A1 (en) | 2005-10-27 |
| RU2372350C2 (ru) | 2009-11-10 |
| US20070213342A1 (en) | 2007-09-13 |
| CN1968951A (zh) | 2007-05-23 |
| BRPI0509777A (pt) | 2007-10-23 |
| AU2005233492A1 (en) | 2005-10-27 |
| RU2009126341A (ru) | 2011-01-20 |
| AU2005233492B2 (en) | 2009-06-11 |
| ZA200608412B (en) | 2008-09-25 |
| UA86617C2 (en) | 2009-05-12 |
| JP2007532637A (ja) | 2007-11-15 |
| EP1737854A1 (en) | 2007-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20110406 |