CA2562802C - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

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Publication number
CA2562802C
CA2562802C CA2562802A CA2562802A CA2562802C CA 2562802 C CA2562802 C CA 2562802C CA 2562802 A CA2562802 A CA 2562802A CA 2562802 A CA2562802 A CA 2562802A CA 2562802 C CA2562802 C CA 2562802C
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CA
Canada
Prior art keywords
ions
ion mobility
ion
transient
electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2562802A
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English (en)
French (fr)
Other versions
CA2562802A1 (en
Inventor
Robert Harold Bateman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
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Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of CA2562802A1 publication Critical patent/CA2562802A1/en
Application granted granted Critical
Publication of CA2562802C publication Critical patent/CA2562802C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CA2562802A 2004-04-20 2005-04-20 Mass spectrometer Expired - Fee Related CA2562802C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0408751.6A GB0408751D0 (en) 2004-04-20 2004-04-20 Mass spectrometer
GB0408751.6 2004-04-20
US58447604P 2004-07-02 2004-07-02
US60/584,476 2004-07-02
PCT/GB2005/001488 WO2005104182A2 (en) 2004-04-20 2005-04-20 Mass spectrometer

Publications (2)

Publication Number Publication Date
CA2562802A1 CA2562802A1 (en) 2005-11-03
CA2562802C true CA2562802C (en) 2014-06-03

Family

ID=32344045

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2562802A Expired - Fee Related CA2562802C (en) 2004-04-20 2005-04-20 Mass spectrometer

Country Status (6)

Country Link
US (1) US9880129B2 (https=)
EP (1) EP1738398B8 (https=)
JP (1) JP4950028B2 (https=)
CA (1) CA2562802C (https=)
GB (3) GB0408751D0 (https=)
WO (1) WO2005104182A2 (https=)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4513488B2 (ja) * 2004-10-06 2010-07-28 株式会社日立製作所 イオンモビリティー分析装置及びイオンモビリティー分析方法
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
US8440968B2 (en) 2005-02-14 2013-05-14 Micromass Uk Limited Ion-mobility analyser
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
US9024255B2 (en) * 2007-07-11 2015-05-05 Excellims Corporation Intelligently controlled spectrometer methods and apparatus
US8785848B2 (en) * 2007-07-11 2014-07-22 Excellims Corporation Parallel ion mass and ion mobility analysis
US7700913B2 (en) * 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8026477B2 (en) 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
CN101063672A (zh) 2006-04-29 2007-10-31 复旦大学 离子阱阵列
RU2327245C2 (ru) * 2006-05-03 2008-06-20 Евгений Васильевич Мамонтов Способ масс-селективного анализа ионов по времени пролета и устройство для его осуществления
GB0624679D0 (en) * 2006-12-11 2007-01-17 Shimadzu Corp A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer
DE102008005281B4 (de) 2008-01-19 2014-09-18 Airsense Analytics Gmbh Verfahren und Vorrichtung zur Detektion und Identifizierung von Gasen
RU2387043C2 (ru) * 2008-04-10 2010-04-20 Евгений Васильевич Мамонтов Способ формирования двумерного линейного поля и устройство для его осуществления
CN101738429B (zh) * 2008-11-26 2013-04-03 岛津分析技术研发（上海）有限公司 离子分离、富集与检测装置
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
US8716655B2 (en) * 2009-07-02 2014-05-06 Tricorntech Corporation Integrated ion separation spectrometer
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
RU2476870C1 (ru) * 2011-11-02 2013-02-27 Федеральное государственное унитарное предприятие "Научно-исследовательский технологический институт имени А.П. Александрова" Способ разделения и регистрации ионов в газе (варианты)
WO2013067366A2 (en) * 2011-11-02 2013-05-10 Leco Corporation Ion mobility spectrometer
US9230790B2 (en) 2011-12-30 2016-01-05 Dh Technologies Development Pte. Ltd. DC ion funnels
GB2519007B (en) * 2012-07-31 2018-09-19 Leco Corp Ion mobility spectrometer with high throughput
WO2014036465A1 (en) * 2012-08-31 2014-03-06 The Regents Of The University Of California A spatially alternating asymmetric field ion mobility spectrometry
FI2906937T3 (fi) 2012-10-10 2023-03-17 Smiths Detection Watford Ltd Kannettava todisteenkeruujärjestelmä ja menetelmä järjestelmän käyttämiseksi
US9165744B2 (en) * 2012-10-24 2015-10-20 Varian Semiconductor Equipment Associates, Inc. Apparatus for treating ion beam
US8809769B2 (en) 2012-11-29 2014-08-19 Bruker Daltonics, Inc. Apparatus and method for cross-flow ion mobility spectrometry
US9916969B2 (en) * 2013-01-14 2018-03-13 Perkinelmer Health Sciences Canada, Inc. Mass analyser interface
CN104112642B (zh) * 2013-04-18 2017-05-24 岛津分析技术研发（上海）有限公司 离子导引装置以及离子导引方法
DE112014005868B4 (de) 2013-12-24 2026-03-26 Micromass Uk Limited Wanderwellen-IMS mit Gegenstrom von Gas
WO2015107612A1 (ja) * 2014-01-14 2015-07-23 株式会社島津製作所 イオン移動度分析装置及び質量分析装置
US10371665B2 (en) * 2014-06-06 2019-08-06 Micromass Uk Limited Mobility selective attenuation
GB201410052D0 (en) * 2014-06-06 2014-07-16 Micromass Ltd Mobility selective attenuation
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
EP4040147A1 (en) * 2014-06-16 2022-08-10 Purdue Research Foundation Sample analysis systems and methods of use thereof
GB2531292B (en) * 2014-10-14 2019-06-12 Smiths Detection Watford Ltd Method and apparatus
US10345261B2 (en) * 2014-12-31 2019-07-09 Dh Technologies Development Pte. Ltd. Differential mobility spectrometry method
US10607826B2 (en) 2015-07-28 2020-03-31 University Of Florida Research Foundation, Incorporated Atmospheric pressure ion guide
WO2017042918A1 (ja) * 2015-09-09 2017-03-16 株式会社島津製作所 イオン移動度分析装置
US9607819B1 (en) * 2016-02-03 2017-03-28 The Charles Stark Draper Laboratory Inc. Non-radioactive, capacitive discharge plasma ion source and method
WO2017195723A1 (ja) * 2016-05-13 2017-11-16 株式会社島津製作所 粒子荷電装置
GB201608653D0 (en) * 2016-05-17 2016-06-29 Micromass Ltd Ion mobility seperator
GB2562690B (en) 2016-09-27 2022-11-02 Micromass Ltd Post-separation mobility analyser
US11668719B2 (en) 2017-09-20 2023-06-06 The Trustees Of Indiana University Methods for resolving lipoproteins with mass spectrometry
JP7102733B2 (ja) 2018-01-04 2022-07-20 株式会社リコー イオン検出装置及び電界非対称波形イオン移動度分光分析システム
US11232941B2 (en) 2018-01-12 2022-01-25 The Trustees Of Indiana University Electrostatic linear ion trap design for charge detection mass spectrometry
CN112840434A (zh) 2018-05-14 2021-05-25 莫比莱昂系统有限公司 离子迁移率谱仪与质谱仪的耦合
JP6874906B2 (ja) * 2018-05-16 2021-05-19 株式会社島津製作所 飛行時間型質量分析装置
GB2602188B (en) 2018-05-31 2023-01-11 Micromass Ltd Mass spectrometer
GB201808949D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808890D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808892D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
GB201808893D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808894D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Mass spectrometer
GB201808936D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
GB201808932D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
US11373849B2 (en) 2018-05-31 2022-06-28 Micromass Uk Limited Mass spectrometer having fragmentation region
GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
EP4376051A3 (en) 2018-06-04 2024-09-25 The Trustees of Indiana University Charge detection mass spectrometry with real time analysis and signal optimization
WO2019236139A1 (en) 2018-06-04 2019-12-12 The Trustees Of Indiana University Interface for transporting ions from an atmospheric pressure environment to a low pressure environment
JP7398810B2 (ja) 2018-06-04 2023-12-15 ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー 静電線形イオン・トラップにイオンを捕獲する装置および方法
WO2019236143A1 (en) 2018-06-04 2019-12-12 The Trustees Of Indiana University Apparatus and method for calibrating or resetting a charge detector
JP7398811B2 (ja) 2018-06-04 2023-12-15 ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー 高スループット電荷検出質量分光分析のためのイオン・トラップ・アレイ
US12089932B2 (en) 2018-06-05 2024-09-17 Trace Matters Scientific Llc Apparatus, system, and method for transferring ions
JP7285023B2 (ja) 2018-11-20 2023-06-01 ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー 単一粒子質量分光分析のためのオービトラップ
CA3118567A1 (en) 2018-12-03 2020-06-11 The Trustees Of Indiana University Apparatus and method for simultaneously analyzing multiple ions with an electrostatic linear ion trap
US10651025B1 (en) 2018-12-21 2020-05-12 Thermo Finnigan Llc Orthogonal-flow ion trap array
WO2020219527A1 (en) 2019-04-23 2020-10-29 The Trustees Of Indiana University Identification of sample subspecies based on particle charge behavior under structural change-inducing sample conditions
WO2020237037A1 (en) 2019-05-21 2020-11-26 MOBILion Systems, Inc. Voltage control for ion mobility separation
CA3156003A1 (en) * 2019-09-25 2021-04-01 The Trustees Of Indiana University Apparatus and method for pulsed mode charge detection mass spectrometry
KR102849777B1 (ko) 2019-10-10 2025-08-22 더 트러스티즈 오브 인디애나 유니버시티 입자들을 식별, 선택 및 정제하기 위한 시스템 및 방법
WO2021102406A1 (en) * 2019-11-22 2021-05-27 MOBILion Systems, Inc. Mobility based filtering of ions
JP7690209B2 (ja) 2019-12-18 2025-06-10 ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー 電荷測定装置を有する質量分析計
CN111029241B (zh) * 2019-12-19 2024-10-01 中国科学院合肥物质科学研究院 一种离子迁移速度补偿的离子迁移谱仪及方法
EP4100991B1 (en) 2020-02-03 2025-01-29 The Trustees of Indiana University A charge detection mass spectrometer and related method
GB2593667A (en) 2020-02-10 2021-10-06 Thermo Electron Mfg Limited Method and apparatus for separating ions
KR102133334B1 (ko) * 2020-02-25 2020-07-14 영인에이스 주식회사 질량분석기
US12163920B2 (en) 2020-04-06 2024-12-10 MOBILion Systems, Inc. Systems and methods for two-dimensional mobility based filtering of ions
US11662333B2 (en) 2020-04-06 2023-05-30 MOBILion Systems, Inc. Systems and methods for two-dimensional mobility based filtering of ions
US11114290B1 (en) 2020-05-07 2021-09-07 Thermo Finnigan Llc Ion funnels and systems incorporating ion funnels
US11581179B2 (en) 2020-05-07 2023-02-14 Thermo Finnigan Llc Ion funnels and systems incorporating ion funnels
CN115885176A (zh) 2020-05-22 2023-03-31 莫比莱昂系统有限公司 用于俘获和积累离子的方法和装置
WO2021247820A1 (en) 2020-06-05 2021-12-09 MOBILion Systems, Inc. Apparatus and methods for ion manipulation having improved duty cycle
CN111710586B (zh) * 2020-06-15 2024-07-05 成都西奇仪器有限公司 一种循环式离子迁移区结构及高分辨率离子迁移谱仪
JP7498653B2 (ja) * 2020-12-09 2024-06-12 シャープ株式会社 イオン生成装置およびイオン移動度分析装置
WO2023203621A1 (ja) * 2022-04-18 2023-10-26 株式会社島津製作所 質量分析装置

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5033895A (https=) 1973-07-25 1975-04-01
US4855595A (en) * 1986-07-03 1989-08-08 Allied-Signal Inc. Electric field control in ion mobility spectrometry
US5420424A (en) 1994-04-29 1995-05-30 Mine Safety Appliances Company Ion mobility spectrometer
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument
US5905258A (en) 1997-06-02 1999-05-18 Advanced Research & Techology Institute Hybrid ion mobility and mass spectrometer
US6960761B2 (en) * 1997-06-02 2005-11-01 Advanced Research & Technology Institute Instrument for separating ions in time as functions of preselected ion mobility and ion mass
JP2002502086A (ja) * 1998-01-23 2002-01-22 アナリティカ オブ ブランフォード インコーポレーテッド 表面からの質量分光測定
WO2001069221A2 (en) 2000-03-14 2001-09-20 National Research Council Canada Tandem high field asymmetric waveform ion mobility spectrometry (faims)/ion mobility spectrometry
WO2001069218A2 (en) 2000-03-14 2001-09-20 National Research Council Canada Tandem faims/ion-trapping apparatus and method
US6933496B2 (en) * 2000-06-23 2005-08-23 The Regents Of The University Of California Ion mobility sensor
US7074232B2 (en) 2000-09-01 2006-07-11 Medtronic Angiolink, Inc. Advanced wound site management systems and methods
US6744043B2 (en) * 2000-12-08 2004-06-01 Mds Inc. Ion mobilty spectrometer incorporating an ion guide in combination with an MS device
JP2005513414A (ja) 2001-06-30 2005-05-12 シオネックス・コーポレーション 電界中におけるデータ収集および未知イオン種識別のためのシステム
US6630662B1 (en) * 2002-04-24 2003-10-07 Mds Inc. Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas
GB2390478B (en) 2002-05-17 2004-06-02 Micromass Ltd Mass spectrometer
JP3971958B2 (ja) * 2002-05-28 2007-09-05 株式会社日立ハイテクノロジーズ 質量分析装置
US6791078B2 (en) * 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer

Also Published As

Publication number Publication date
US9880129B2 (en) 2018-01-30
WO2005104182A3 (en) 2006-11-02
WO2005104182A2 (en) 2005-11-03
GB2413433A (en) 2005-10-26
JP2007534126A (ja) 2007-11-22
GB2428875A (en) 2007-02-07
EP1738398B8 (en) 2015-07-22
GB2413433B (en) 2007-03-21
EP1738398B1 (en) 2015-06-03
US20110095175A1 (en) 2011-04-28
GB0508007D0 (en) 2005-05-25
GB0619276D0 (en) 2006-11-08
GB2428875B (en) 2008-09-03
JP4950028B2 (ja) 2012-06-13
EP1738398A2 (en) 2007-01-03
GB0408751D0 (en) 2004-05-26
CA2562802A1 (en) 2005-11-03

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