WO2005104182A2 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

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Publication number
WO2005104182A2
WO2005104182A2 PCT/GB2005/001488 GB2005001488W WO2005104182A2 WO 2005104182 A2 WO2005104182 A2 WO 2005104182A2 GB 2005001488 W GB2005001488 W GB 2005001488W WO 2005104182 A2 WO2005104182 A2 WO 2005104182A2
Authority
WO
WIPO (PCT)
Prior art keywords
ions
transient
ion mobility
mbar
electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2005/001488
Other languages
English (en)
French (fr)
Other versions
WO2005104182A3 (en
Inventor
Robert Harold Bateman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority to US11/568,167 priority Critical patent/US9880129B2/en
Priority to CA2562802A priority patent/CA2562802C/en
Priority to EP05734046.5A priority patent/EP1738398B8/en
Priority to JP2007508963A priority patent/JP4950028B2/ja
Publication of WO2005104182A2 publication Critical patent/WO2005104182A2/en
Anticipated expiration legal-status Critical
Publication of WO2005104182A3 publication Critical patent/WO2005104182A3/en
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides

Definitions

  • Ion mobility of an ion is generally closely related to its cross sectional area and its charge.
  • Ionisation sources for ion mobility spectrometers of samples in the gaseous phase include radioactive nickel, Atmospheric Pressure Chemical Ionisation ion sources and photoionisation ion sources. More recently ion mobility spectrometry of polar samples in liquid solution has become possible using Electrospray Ionization ("ESI"). Ion mobility spectrometers provide simple, inexpensive, high throughput screening under ambient conditions. More recently a variation of a conventional ion mobility spectrometer has been developed known as a Field Asymmetric Ion Mobility Spectrometry (“FAIMS”) device.
  • FIMS Field Asymmetric Ion Mobility Spectrometry
  • the ions will then tend to drift towards one or other of the plates or electrodes.
  • An ion will drift towards a plate or electrode due to the fact that the mobility of the ion during the application of a relatively high strength electric field is different to the mobility of the ion during the application of a relatively low strength electric field. Since the mobility of the ion defines how fast the ion moves in an electric field, the ion will move proportionately farther in a relatively high strength electric field than the ion will move in a relatively low strength electric field (or vice versa) .
  • the asymmetric voltage waveform which is typically applied tends to have a relatively high frequency e.g. > 200 kHz.
  • apparatus comprising: a first device for separating ions according to their ion mobility or according to their rate of change of ion mobility with electric field strength; and a second separate device for separating ions according to their ion mobility or according to their rate of change of ion mobility with electric field strength, the second device being arranged downstream of the first device.
  • the first device is preferably arranged to separate ions according to their rate of change of ion mobility with electric field strength.
  • the first device comprises a Field Asymmetric Ion Mobility Spectrometry ("FAIMS”) device.
  • the first device may comprise at least a first electrode and a second electrode and wherein ions are arranged to be received, in use, between the first and second electrodes.
  • the second electrode is at the second reference potential and the third electrode is at the third reference potential; at the second time t 2 the first electrode is at the first potential and the third electrode is at the third reference potential; and at the third time t 3 the first electrode is at the first potential and the second electrode is at the second potential.

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
PCT/GB2005/001488 2004-04-20 2005-04-20 Mass spectrometer Ceased WO2005104182A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/568,167 US9880129B2 (en) 2004-04-20 2005-04-20 Mass spectrometer
CA2562802A CA2562802C (en) 2004-04-20 2005-04-20 Mass spectrometer
EP05734046.5A EP1738398B8 (en) 2004-04-20 2005-04-20 Mass spectrometer
JP2007508963A JP4950028B2 (ja) 2004-04-20 2005-04-20 質量分析計

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0408751.6A GB0408751D0 (en) 2004-04-20 2004-04-20 Mass spectrometer
GB0408751.6 2004-04-20
US58447604P 2004-07-02 2004-07-02
US60/584,476 2004-07-02

Publications (2)

Publication Number Publication Date
WO2005104182A2 true WO2005104182A2 (en) 2005-11-03
WO2005104182A3 WO2005104182A3 (en) 2006-11-02

Family

ID=32344045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/001488 Ceased WO2005104182A2 (en) 2004-04-20 2005-04-20 Mass spectrometer

Country Status (6)

Country Link
US (1) US9880129B2 (https=)
EP (1) EP1738398B8 (https=)
JP (1) JP4950028B2 (https=)
CA (1) CA2562802C (https=)
GB (3) GB0408751D0 (https=)
WO (1) WO2005104182A2 (https=)

Cited By (11)

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JP2009529141A (ja) * 2006-03-03 2009-08-13 イオンセンス インコーポレイテッド 表面イオン化分光に使用するためのサンプリングシステム
RU2387043C2 (ru) * 2008-04-10 2010-04-20 Евгений Васильевич Мамонтов Способ формирования двумерного линейного поля и устройство для его осуществления
WO2010060380A1 (zh) * 2008-11-26 2010-06-03 岛津分析技术研发（上海）有限公司 离子分离、富集与检测装置
WO2013098598A1 (en) * 2011-12-30 2013-07-04 Dh Technologies Development Pte. Ltd Dc ion funnels
US20130187037A1 (en) * 2007-07-11 2013-07-25 Excellims Corporation Parallel ion mass and ion mobility analysis
US8525109B2 (en) 2006-03-03 2013-09-03 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
WO2014085643A1 (en) * 2012-11-29 2014-06-05 Bruker Daltonics, Inc. Apparatus and method for cross-flow ion mobility spectrometry
US8895916B2 (en) 2009-05-08 2014-11-25 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US9417211B2 (en) 2011-11-02 2016-08-16 Leco Corporation Ion mobility spectrometer with ion gate having a first mesh and a second mesh
US9824875B2 (en) 2014-06-15 2017-11-21 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US10942149B2 (en) 2018-01-04 2021-03-09 Ricoh Company, Ltd. Ion sensor, ion sensor manufacturing method, and field asymmetric ion mobility spectrometry system

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JP4513488B2 (ja) * 2004-10-06 2010-07-28 株式会社日立製作所 イオンモビリティー分析装置及びイオンモビリティー分析方法
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
US8440968B2 (en) 2005-02-14 2013-05-14 Micromass Uk Limited Ion-mobility analyser
GB0503010D0 (en) * 2005-02-14 2005-03-16 Micromass Ltd Mass spectrometer
US9024255B2 (en) * 2007-07-11 2015-05-05 Excellims Corporation Intelligently controlled spectrometer methods and apparatus
CN101063672A (zh) 2006-04-29 2007-10-31 复旦大学 离子阱阵列
RU2327245C2 (ru) * 2006-05-03 2008-06-20 Евгений Васильевич Мамонтов Способ масс-селективного анализа ионов по времени пролета и устройство для его осуществления
GB0624679D0 (en) * 2006-12-11 2007-01-17 Shimadzu Corp A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer
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GB2519007B (en) * 2012-07-31 2018-09-19 Leco Corp Ion mobility spectrometer with high throughput
WO2014036465A1 (en) * 2012-08-31 2014-03-06 The Regents Of The University Of California A spatially alternating asymmetric field ion mobility spectrometry
FI2906937T3 (fi) 2012-10-10 2023-03-17 Smiths Detection Watford Ltd Kannettava todisteenkeruujärjestelmä ja menetelmä järjestelmän käyttämiseksi
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DE112014005868B4 (de) 2013-12-24 2026-03-26 Micromass Uk Limited Wanderwellen-IMS mit Gegenstrom von Gas
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US10371665B2 (en) * 2014-06-06 2019-08-06 Micromass Uk Limited Mobility selective attenuation
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JP6874906B2 (ja) * 2018-05-16 2021-05-19 株式会社島津製作所 飛行時間型質量分析装置
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GB201808932D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
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GB201808912D0 (en) 2018-05-31 2018-07-18 Micromass Ltd Bench-top time of flight mass spectrometer
EP4376051A3 (en) 2018-06-04 2024-09-25 The Trustees of Indiana University Charge detection mass spectrometry with real time analysis and signal optimization
WO2019236139A1 (en) 2018-06-04 2019-12-12 The Trustees Of Indiana University Interface for transporting ions from an atmospheric pressure environment to a low pressure environment
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JP7398811B2 (ja) 2018-06-04 2023-12-15 ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー 高スループット電荷検出質量分光分析のためのイオン・トラップ・アレイ
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Cited By (17)

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Publication number Priority date Publication date Assignee Title
JP2009529141A (ja) * 2006-03-03 2009-08-13 イオンセンス インコーポレイテッド 表面イオン化分光に使用するためのサンプリングシステム
US8525109B2 (en) 2006-03-03 2013-09-03 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US20130187037A1 (en) * 2007-07-11 2013-07-25 Excellims Corporation Parallel ion mass and ion mobility analysis
US8785848B2 (en) * 2007-07-11 2014-07-22 Excellims Corporation Parallel ion mass and ion mobility analysis
US20140367567A1 (en) * 2007-07-11 2014-12-18 Excellims Corporation Parallel ion mass and ion mobility analysis
US9142395B2 (en) * 2007-07-11 2015-09-22 Excelliris Corp. Parallel ion mass and ion mobility analysis
RU2387043C2 (ru) * 2008-04-10 2010-04-20 Евгений Васильевич Мамонтов Способ формирования двумерного линейного поля и устройство для его осуществления
WO2010060380A1 (zh) * 2008-11-26 2010-06-03 岛津分析技术研发（上海）有限公司 离子分离、富集与检测装置
US8384025B2 (en) 2008-11-26 2013-02-26 Shimadzu Research Laboratory (Shanghai) Co. Ltd Device for separating, enriching and detecting ions
US9633827B2 (en) 2009-05-08 2017-04-25 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US8895916B2 (en) 2009-05-08 2014-11-25 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US9417211B2 (en) 2011-11-02 2016-08-16 Leco Corporation Ion mobility spectrometer with ion gate having a first mesh and a second mesh
WO2013098598A1 (en) * 2011-12-30 2013-07-04 Dh Technologies Development Pte. Ltd Dc ion funnels
US9230790B2 (en) 2011-12-30 2016-01-05 Dh Technologies Development Pte. Ltd. DC ion funnels
WO2014085643A1 (en) * 2012-11-29 2014-06-05 Bruker Daltonics, Inc. Apparatus and method for cross-flow ion mobility spectrometry
US9824875B2 (en) 2014-06-15 2017-11-21 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US10942149B2 (en) 2018-01-04 2021-03-09 Ricoh Company, Ltd. Ion sensor, ion sensor manufacturing method, and field asymmetric ion mobility spectrometry system

Also Published As

Publication number Publication date
US9880129B2 (en) 2018-01-30
WO2005104182A3 (en) 2006-11-02
CA2562802C (en) 2014-06-03
GB2413433A (en) 2005-10-26
JP2007534126A (ja) 2007-11-22
GB2428875A (en) 2007-02-07
EP1738398B8 (en) 2015-07-22
GB2413433B (en) 2007-03-21
EP1738398B1 (en) 2015-06-03
US20110095175A1 (en) 2011-04-28
GB0508007D0 (en) 2005-05-25
GB0619276D0 (en) 2006-11-08
GB2428875B (en) 2008-09-03
JP4950028B2 (ja) 2012-06-13
EP1738398A2 (en) 2007-01-03
GB0408751D0 (en) 2004-05-26
CA2562802A1 (en) 2005-11-03

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