CA2562018A1 - Endoprotheses vasculaires bioactives concues pour le diabete type ii et leurs procedes d'utilisation - Google Patents

Endoprotheses vasculaires bioactives concues pour le diabete type ii et leurs procedes d'utilisation Download PDF

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Publication number
CA2562018A1
CA2562018A1 CA002562018A CA2562018A CA2562018A1 CA 2562018 A1 CA2562018 A1 CA 2562018A1 CA 002562018 A CA002562018 A CA 002562018A CA 2562018 A CA2562018 A CA 2562018A CA 2562018 A1 CA2562018 A1 CA 2562018A1
Authority
CA
Canada
Prior art keywords
polymer
stent
bioligand
biodegradable
bioactive agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002562018A
Other languages
English (en)
Inventor
Kenneth W. Carpenter
William G. Turnell
Kristen M. Defife
Kathryn A. Grako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivas LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2562018A1 publication Critical patent/CA2562018A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une endoprothèse vasculaire ou un autre dispositif médical implantable susceptible d'être enveloppée d'un polymère biocompatible biodégradable auquel on fixe un ligand biologique qui capture spécifiquement des progéniteurs de cellules endothéliales (PEC) dans le sang en circulation afin de favoriser la formation endogène d'un endothélium sain dans le diabète type II. Dans un mode de réalisation, le ligand biologique est un peptide qui se lie spécifiquement à un récepteur des intégrines sur les PEC. L'invention concerne également des procédés permettant d'utiliser des endoprothèses vasculaires et d'autres dispositifs médicaux implantables pour favoriser la guérison vasculaire dans le diabète type II, par exemple à la suite d'une intervention mécanique.
CA002562018A 2004-04-05 2005-04-04 Endoprotheses vasculaires bioactives concues pour le diabete type ii et leurs procedes d'utilisation Abandoned CA2562018A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55993704P 2004-04-05 2004-04-05
US60/559,937 2004-04-05
PCT/US2005/011231 WO2005097186A2 (fr) 2004-04-05 2005-04-04 Endoprotheses vasculaires bioactives conçues pour le diabete type ii et leurs procedes d'utilisation

Publications (1)

Publication Number Publication Date
CA2562018A1 true CA2562018A1 (fr) 2005-10-20

Family

ID=35125623

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002562018A Abandoned CA2562018A1 (fr) 2004-04-05 2005-04-04 Endoprotheses vasculaires bioactives concues pour le diabete type ii et leurs procedes d'utilisation

Country Status (6)

Country Link
EP (1) EP1737379A4 (fr)
JP (1) JP2007532185A (fr)
CN (1) CN1984620B (fr)
AU (1) AU2005231458A1 (fr)
CA (1) CA2562018A1 (fr)
WO (1) WO2005097186A2 (fr)

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US20160287708A9 (en) * 2000-03-15 2016-10-06 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US20060271168A1 (en) * 2002-10-30 2006-11-30 Klaus Kleine Degradable medical device
US7959659B2 (en) 2004-01-02 2011-06-14 Advanced Cardiovascular Systems, Inc. High-density lipoprotein coated medical devices
US8163269B2 (en) * 2004-04-05 2012-04-24 Carpenter Kenneth W Bioactive stents for type II diabetics and methods for use thereof
WO2007035938A2 (fr) 2005-09-22 2007-03-29 Medivas, Llc FORMULES DE POLY(ESTER AMIDE) ET DE POLY(ESTER URÉTHANE) CONTENANT DES DIESTERS DE BIS-(α-AMINO)-DIOL ET MÉTHODES D'EMPLOI
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
JP2009524584A (ja) * 2005-12-07 2009-07-02 メディバス エルエルシー ポリマー−生物製剤送達組成物を構築するための方法
JP5196498B2 (ja) * 2006-05-09 2013-05-15 メディバス エルエルシー 生分解性水溶性ポリマー
US7572625B2 (en) 2006-05-18 2009-08-11 Boston Scientific Scimed, Inc. Medical devices coated with drug carrier macromolecules
US20080172124A1 (en) * 2007-01-11 2008-07-17 Robert Lamar Bjork Multiple drug-eluting coronary artery stent for percutaneous coronary artery intervention
EP2178541A4 (fr) * 2007-07-17 2012-11-14 Medivas Llc Dispositif de soutien artériel élastomère bioabsorbable et procédés d'utilisation
US20090074831A1 (en) * 2007-09-18 2009-03-19 Robert Falotico LOCAL VASCULAR DELIVERY OF mTOR INHIBITORS IN COMBINATION WITH PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR STIMULATORS
DE102008027095A1 (de) * 2008-06-06 2009-12-17 Siemens Aktiengesellschaft Interventionsvorrichtung zur Sammlung von biologischem Material und Verfahren zu ihrer Herstellung
CN101879102B (zh) * 2009-05-07 2014-07-09 上海微创医疗器械（集团）有限公司 一种凹槽携载式涂层可降解型药物洗脱支架
IN2012DN02078A (fr) * 2009-10-16 2015-08-21 Dsm Ip Assets Bv
CN103619910B (zh) 2011-06-23 2016-08-31 帝斯曼知识产权资产管理有限公司 用于药物递送的新颖的聚酯酰胺共聚物
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
JP2014529997A (ja) * 2011-09-23 2014-11-17 ウニヴェルズィテート シュトゥットガルト 免疫グロブリン結合ドメインを使った血清中半減期延長
US9220759B2 (en) 2012-02-23 2015-12-29 Abbott Cardiovascular Systems Inc. Treatment of diabetic patients with a drug eluting stent and adjunctive therapy
US9220584B2 (en) 2012-03-30 2015-12-29 Abbott Cardiovascular Systems Inc. Treatment of diabetic patients with a stent and locally administered adjunctive therapy
WO2014096339A1 (fr) * 2012-12-20 2014-06-26 Dsm Ip Assets B.V. Revêtement comprenant des copolymères de polyesteramide pour l'administration de médicament
EP3233067B1 (fr) 2014-12-18 2019-11-06 DSM IP Assets B.V. Système d'administration de médicament pour délivrer des médicaments sensibles à l'acide
WO2021110474A1 (fr) * 2019-12-04 2021-06-10 Cortronik GmbH Fibres hybrides polymères gonflables pour un manchon d'une endoprothèse intraluminale

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1256635A (zh) * 1997-05-22 2000-06-14 默克专利股份有限公司 肽包被的植入物及其制备方法
US7052711B2 (en) * 1999-09-02 2006-05-30 Rice University Nitric oxide-producing hydrogel materials
US6379383B1 (en) * 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
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GB0103668D0 (en) * 2001-02-15 2001-03-28 Biointeractions Ltd Methods and clinical devices for the inhibition or prevention of mammalian cell growth
CA2435306C (fr) * 2001-02-16 2010-12-21 Stephan Wnendt Implants avec fk506
US20030064053A1 (en) * 2001-08-31 2003-04-03 Shengjiang Liu Multivalent protein conjugate with multiple ligand-binding domains of receptors
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CA2472031C (fr) * 2002-02-06 2008-09-16 Orbus Medical Technologies Inc. Dispositif medical recouvert d'un revetement qui facilite la fixation et la differenciation de cellules endotheliales
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AU2004215898A1 (en) * 2003-02-26 2004-09-10 Medivas, Llc Bioactive stents and methods for use thereof
DE602004024053D1 (de) * 2003-05-07 2009-12-24 Advanced Bio Prothestic Surfac Metallische implantierbare prothesen und herstellungsverfahren dafür
US20070009481A1 (en) * 2003-07-17 2007-01-11 Martin Laser Use of fak-related non-kinase in the manufacture of a medicament for the inhibition of stenosis and restenosis

Also Published As

Publication number Publication date
EP1737379A4 (fr) 2011-08-17
CN1984620B (zh) 2011-03-30
WO2005097186A3 (fr) 2006-09-14
JP2007532185A (ja) 2007-11-15
WO2005097186A2 (fr) 2005-10-20
AU2005231458A1 (en) 2005-10-20
EP1737379A2 (fr) 2007-01-03
CN1984620A (zh) 2007-06-20

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130404

FZDE Discontinued

Effective date: 20130404